Jakub Szabó

Acetaminophen-induced liver injury triggers short- and long-term neuroinflammation, blood–brain barrier disruption, and behavioral deficits in a genetic mouse model of autism

Jakub Szabó, Andrej Feješ, Ladislav Bačiak, Gabriela Fujeríková et autres

Autism Spectrum Disorder (ASD) is a neurodevelopmental condition with a strong genetic basis, yet its etiology is not fully understood. Neuroinflammation is emerging as a critical secondary factor. Since peripheral organ injury, such as acute liver failure, can induce neuroinflammation, we aimed …

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Neonatal testosterone exposure modulates exploration and object avoidance without exacerbating autism-like behavior in Shank3b-deficient mice

Petronela Sušienková, Jakub Szabó, Johan Filo, Veronika Borbélyová et autres

A rapid increase in autism spectrum disorder (ASD) prevalence, high heritability, and higher incidence in boys suggest a role of gene-environment interactions, likely involving sex hormones in its etiology. Prenatal exposure to high testosterone concentration has been linked to risk of ASD, …

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Age‐associated changes in neuroimaging biomarkers in a non‐human primate model of cerebral amyloid angiopathy

Suleiman Khan, Muhammad T Soliman, Sean Murray, Jakub Szabó et autres

Abstract Background Amyloid related imaging abnormalities (ARIA) have emerged as indicators of potentially serious side effects in therapeutics for Alzheimer's disease (AD). Squirrel monkeys (SQMs) are a unique non‐human primate (NHP) model for studying ARIA, due to their propensity of naturally developing …

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R2* Mapping in a Primate Model of CAA Shows Aging-Related Increases in GM and Reversal in WM with Transient Edema

Youssef Zaim Wadghiri, Jakub Szabó, Suleiman Khan, Muhammad T Soliman et autres

Motivation: Amyloid-related imaging abnormalities (ARIA), seen in Alzheimer's patients (AD) undergoing anti-amyloid immunotherapy, are partly caused by cerebral amyloid angiopathy (CAA). Squirrel monkeys (SQMs) offer a unique model for studying ARIA Goal(s): Characterize MR imaging biomarkers in aging SQMs using conventional MRI …

Autism-like phenotype across the lifespan of Shank3B-mutant mice of both sexes

Jakub Szabó, Johan Filo, Rebeka Démuthová, Emese Renczés et autres

Abstract Background High heritability (80–90%) of the autism spectrum disorder (ASD) and sex-biased incidence (3–4 times more boys than girls) suggest the roles of genetic predisposition and sex in the etiopathogenesis of the disorder. As ASD is commonly diagnosed in early childhood, …

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The Effect of Parental Faecal Microbiome Transplantation from Children with Autism Spectrum Disorder on Behavior and Gastrointestinal Manifestations in the Male Offspring of Shank3 Mice

Veronika Borbélyová, Jakub Szabó, Petronela Sušienková, Judith Potvin et autres

The increasing incidence of autism spectrum disorder (ASD) increases the urgency of establishing the mechanism of its development for effective prevention and treatment. ASD’s etiology includes genetic predisposition and environmental triggers, both of which can play a role in the changed microbiota. …

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Multi‐Parametric MRI assessment of biomarkers in a non‐human primate model exhibiting sporadic cerebral amyloid angiopathy

Suleiman Khan, Sean Murray, Jakub Szabó, Muhammad T Soliman et autres

Abstract Background Cerebral amyloid angiopathy (CAA) has been recognized as one of the morphologic hallmarks of Alzheimer disease (AD). The development of new AD drugs has brought unforeseen challenges that manifest as amyloid‐related imaging abnormalities (ARIA) appearing as vasogenic edema/effusion (ARIA‐E) and …

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Susceptibility based magnetic resonance imaging for development of neuroimaging biomarkers

Lauren O’Donnell, Suleiman Khan, Hannah Goldman, Sean Murray et autres

Abstract Background Amyloid related imaging abnormalities (ARIA), a group of neuropathological features seen in anti‐amyloid immunotherapy patients, arises partly from CAA (Aβ buildup in blood vessels). Squirrel monkeys (SQMs), developing prominent age‐related CAA exceeding brain Aβ, offer a unique NHP model for …

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Exploring Pathology Along the White Matter Tract near Hyperintense Vasogenic Edema through Multiparametric MRI and Diffusion

Youssef Zaim Wadghiri, Jelle Veraart, Sean Murray, Jakub Szabó et autres

Motivation: There is a critical need for neuroimaging methodologies that can characterize the neuropathological changes associated with cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD). Goal(s): Our goal was to explore CAA-associated pathology using multiparametric MRI including diffusion MRI. Approach: A combination …

Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD

Jakub Szabó, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková et autres

Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders with heterogeneous symptomatology. Arguably, the most pervasive shortfall of ASD are the deficits in sociability and the animal models of the disorder are expected to exhibit such impairments. The most widely utilized …

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Multi-parametric MRI Characterization of the Aging Squirrel Monkey as a Model of Sporadic Cerebral Amyloid Angiopathy

Youssef Zaim Wadghiri, Jelle Veerart, Sean Murray, Jakub Szabó et autres

The current study seeks to identify neuroimaging biomarkers in a unique squirrel monkey (SQM) as a spontaneous model of cerebral amyloid angiopathy both in vivo and ex vivo using conventional MRI metrics in young and geriatric SQM cohorts and demonstrate the utility …

Increasing Property Tax Payment Rates on Time Through Simplification of Communication with Citizens

Matúš Sloboda, Patrik Pavlovský, Emília Sičáková-Beblavá, Jakub Szabó