Veronika Borbélyová

Long-term monitoring reveals immobility-defined sleep fragmentation and behavioural alterations in collagen-induced arthritis mouse model of both sexes

Kristína Macáková, Jakub Szabó, Emma Skybová, Barbora Vlková et autres

sk (code pays fourni par la source)

Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease

Alexandra Gaál Kovalčíková, Gabriela Forraiová, Nelia Korotushak, Veronika Borbélyová et autres

Neutrophil extracellular traps (NETs) are suggested to play a role in chronic kidney disease (CKD). Whether they are indeed involved in the pathogenesis of animal models of CKD has not been proved. This study tested the hypothesis that a genetic deficiency of …

sk (code pays fourni par la source)

Neonatal testosterone exposure modulates exploration and object avoidance without exacerbating autism-like behavior in Shank3b-deficient mice

Petronela Sušienková, Jakub Szabó, Johan Filo, Veronika Borbélyová et autres

A rapid increase in autism spectrum disorder (ASD) prevalence, high heritability, and higher incidence in boys suggest a role of gene-environment interactions, likely involving sex hormones in its etiology. Prenatal exposure to high testosterone concentration has been linked to risk of ASD, …

sk (code pays fourni par la source)

Sex-specific effects of peptidyl arginine deiminase 4 deficiency in the cafeteria diet-induced obesity-associated metabolic complications

Andrej Feješ, Emil Bečka, Ivana Feješ Slivková, Kristína Macáková et autres

Background Obesity is a global health challenge linked to chronic non-communicable diseases. Low-grade inflammation and altered immune responses, including neutrophil extracellular trap (NET) formation, contribute to metabolic complications. Peptidyl arginine deiminase 4 (PAD4) is critical for NET formation, and its inhibition shows …

sk (code pays fourni par la source)

Modeling Ischemia-Induced Neuronal Loss in Neurological Diseases: Experimental Approaches for Stroke, Epilepsy, and Migraine

Sparsh Goel, Veronika Borbélyová, Jakub Otáhal, V. RILJAK

cz, sk (code pays fourni par la source)

Pametne kletke, večja dobrobit

Rohish Kaura, Dragan Hrnčić, Amela Dervišević, Veronika Borbélyová et autres

High welfare standards for animals used in research is as much an ethical issue as it is a cornerstone of high-quality science. Researchers can improve both animal welfare and data reliability by implementing strategies that reduce stress in experimental animals. One modern …

ee, rs, ba, sk, hr, si (code pays fourni par la source)

Cafeteria and Fast-Food Diets Induce Neuroinflammation, Social Deficits, but a Different Cardiometabolic Phenotype

Andrej Feješ, Petronela Sušienková, Lucia Mihalovičová, Veronika Kunšteková et autres

BACKGROUND: Obesity is a risk factor for several non-communicable diseases and premature death. The Western-type diet, rich in calories and diverse in tastes, smells, and textures, promotes the onset and progression of obesity. We compared the effects of two Western-style palatable obesogenic …

sk (code pays fourni par la source)

Effect of Sacubitril/Valsartan, Ivabradine, and Captopril on Anxiety-like Behavior in Spontaneously Hypertensive Rats

Maria Szighardtova, Silvia Aziriova, Peter Stanko, Kristina Repova et autres

Cardiovascular disorders and the medications used to treat them can affect physiological patterns of behavior. The aim of the present study was to determine whether the dual inhibition of neprilysin and angiotensin II-sacubitril/valsartan (ARNI) can modify anxiety-like behavior in male spontaneously hypertensive …

sk, cz (code pays fourni par la source)

SMART CAGES, BETTER WELFARE: SUPPORTING THE 3RS IN ANIMAL RESEARCH WITH HOME-CAGE MONITORING AND SYSTEM SELECTION

R. L. Kaura, Dragan Hrnčić, Amela Dervišević, Veronika Borbélyová et autres

High welfare standards for animals used in research is as much an ethical issue as it is a cornerstone of high-quality science. Researchers can improve both animal welfare and data reliability by implementing strategies that reduce stress in experimental animals. One modern …

ee, rs, ba, sk, tr, hr, si (code pays fourni par la source)

Autism-like phenotype across the lifespan of Shank3B-mutant mice of both sexes

Jakub Szabó, Johan Filo, Rebeka Démuthová, Emese Renczés et autres

Abstract Background High heritability (80–90%) of the autism spectrum disorder (ASD) and sex-biased incidence (3–4 times more boys than girls) suggest the roles of genetic predisposition and sex in the etiopathogenesis of the disorder. As ASD is commonly diagnosed in early childhood, …

sk (code pays fourni par la source)

Myeloperoxidase, extracellular DNA and neutrophil extracellular trap formation in the animal models of metabolic dysfunction-associated steatotic liver disease

Andrej Feješ, Paulína Belvončíková, Emil Bečka, Tomáš Strečanský et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver disorder driven by obesity and metabolic dysfunction. MASLD progresses to metabolic dysfunction-associated steatohepatitis, which is characterized by inflammation, hepatocyte injury, and fibrosis, increasing the risk of cirrhosis and liver failure. …

sk (code pays fourni par la source)

The Effect of Parental Faecal Microbiome Transplantation from Children with Autism Spectrum Disorder on Behavior and Gastrointestinal Manifestations in the Male Offspring of Shank3 Mice

Veronika Borbélyová, Jakub Szabó, Petronela Sušienková, Judith Potvin et autres

The increasing incidence of autism spectrum disorder (ASD) increases the urgency of establishing the mechanism of its development for effective prevention and treatment. ASD’s etiology includes genetic predisposition and environmental triggers, both of which can play a role in the changed microbiota. …

sk, cz (code pays fourni par la source)