Bénazir Siddeek

Placenta Myo-Inositol in Women at Risk for Gestational Diabetes Mellitus

Pierluigi Di Vinci, Bénazir Siddeek, Isabella Neri, Umberto Siméoni et autres

Keywords myoinositol - placenta - gestational diabetes mellitus - obesity - birth weight Publication History Article published online: 06 November 2025 © 2025. Thieme. All rights reserved. Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

it, ch (code pays fourni par la source)

Maternal exposure to high-fat diet induces long-term mitochondrial alterations in the offspring heart

Mariapia Chindamo, Hassib Chehade, Anthony Sordet, Gaël Humbert-Droz et autres

Heart disease is a leading cause of death worldwide, with its prevalence exacerbated by inadequate nutritional intake. Particularly concerning is the elevated risk induced by imbalanced nutrition during development, which can impact lifelong heart health. Recent research has underscored mitochondrial dysregulation as …

ch, fr (code pays fourni par la source)

854 Inositols pathway is altered in placental tissue of obese women

Pierluigi Di Vinci, Fabio Facchinetti, Bénazir Siddeek, Umberto Siméoni

it, ch (code pays fourni par la source)

ITPR1 mRNA expression is downregulated in obese placental cells

Pierluigi Di Vinci, Bénazir Siddeek, Umberto Siméoni, Fabio Facchinetti

it, ch (code pays fourni par la source)

Transient Post-Natal Exposure to Xenoestrogens Induces Long-Term Alterations in Cardiac Calcium Signaling

Cassandra Tabasso, Marie-Pauline Frossard, Camille Ducret, Hassib Chehade et autres

Today, non-communicable disorders are widespread worldwide. Among them, cardiovascular diseases represent the main cause of death. At the origin of these diseases, exposure to challenges during developmental windows of vulnerability (peri-conception, in utero, and early infancy periods) have been incriminated. Among the …

ch, fr (code pays fourni par la source)

Epigenetics provides a bridge between early nutrition and long‐term health and a target for disease prevention

Bénazir Siddeek, Umberto Siméoni

Exposure to nutritional imbalance during early life can influence disease risk lifelong and across generations. In this long-term conditioning, epigenetics constitutes a key mechanism. They bridge environmental cues and the expression of genes involved in the setting of long-standing biological regulations in …

ch (code pays fourni par la source)

Renal Programming by Transient Postnatal Overfeeding: The Role of Senescence Pathways

Christian Juvet, Bénazir Siddeek, Catherine Yzydorczyk, Catherine Vergely et autres

Background: Early nutrition influences the risk of Chronic Kidney Diseases development in adulthood. Mechanisms underlying the early programming of altered renal function remain incompletely understood. This study aims at characterizing the role of cell senescence pathways in early programming of Chronic Kidney …

ch, fr (code pays fourni par la source)

Renal programming by transient postnatal overfeeding: the role of senescence pathways

Christian Juvet, Bénazir Siddeek, Catherine Yzydorczyk, Catherine Vergely et autres

Western Blots for the following proteins in the mouse kidney at weaning and adulthood: P-Rb, Rb, P16, P21, P53, Sirt1. Actin was used for for normalization. CTRL: control group. OF: overfeeding group.

ch, fr (code pays fourni par la source)

Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart

Guillaume Blin, Marjorie Liand, Claire Mauduit, Hassib Chehade et autres

Heart diseases are a leading cause of death. While the link between early exposure to nutritional excess and heart disease risk is clear, the molecular mechanisms involved are poorly understood. In the developmental programming field, increasing evidence is pointing out the critical …

ch, fr (code pays fourni par la source)

Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice

Catherine Yzydorczyk, Na Li, Eve Rigal, Hassib Chehade et autres

Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this …

ch, fr (code pays fourni par la source)

Long-term impact of maternal high-fat diet on offspring cardiac health: role of micro-RNA biogenesis

Bénazir Siddeek, Claire Mauduit, Hassib Chehade, Guillaume Blin et autres

Heart failure is a worldwide leading cause of death. Diet and obesity are particularly of high concern in heart disease etiology. Gravely, altered nutrition during developmental windows of vulnerability can have long-term impact on heart health; however, the underlying mechanisms are poorly …

ch, fr (code pays fourni par la source)

Sperm epigenome as a marker of environmental exposure and lifestyle, at the origin of diseases inheritance

Bénazir Siddeek, Claire Mauduit, Umberto Siméoni, Mohamed Benahmed

ch, fr (code pays fourni par la source)