SSRI-induced modulation of cytokines, barrier permeability, and BDNF in adolescent depression
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Le résumé fourni par la source
BACKGROUND: Emerging evidence links immune activation to antidepressant response in adolescents with major depressive disorder (MDD). We examined how depressive symptoms, quality of life (QOL), and blood markers of inflammation, blood–brain barrier (BBB) integrity, and gut permeability change following antidepressant treatment in this population. METHODS: Twenty-six adolescents with MDD were evaluated at baseline (pre-treatment), 12 weeks, and 24 weeks after starting therapy. Depression and anxiety were measured by the Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA). QOL was assessed with the QOL Scale for Children and Adolescents (QLSCA) and an adolescent social support instrument. Serum levels of IL-1β, TNF-α, IL-6, IL-4, S100β, claudin-5, LBP, I-FABP, and brain-derived neurotrophic factor (BDNF) were quantified. RESULTS: At baseline, pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and IL-4 strongly correlated with BBB (S100β, claudin-5) and gut-permeability (I-FABP) markers. IL-4 levels rose significantly and were associated with reduced anxiety (HAMA: r = −0.48, p < 0.05) and better QOL (QLSCA: r = 0.57, p < 0.01). BBB integrity and gut-permeability markers remained stable. In responders only, BDNF increased at 12 weeks (p < 0.05) and IL-8 rose at 24 weeks (p < 0.05), suggesting their involvement in treatment efficacy. CONCLUSIONS: Antidepressant therapy in adolescents with MDD is accompanied by dynamic elevations in IL-4, IL-8, and BDNF that parallel clinical improvement and enhanced QOL. These biomarkers warrant further study to develop more targeted interventions for adolescent depression. CLINICAL TRIAL NUMBER: Not applicable.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- SSRI-induced modulation of cytokines, barrier permeability, and BDNF in adolescent depression
- Date Crossref
- 02/12/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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First Affiliated Hospital of Xi'an Jiaotong University Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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Yulin University pays non établi dans la noticeUniversité ou école supérieure
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Chiba University Center for Forensic Mental Health pays non établi dans la noticeÉtablissement de santé
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Xi'an Jiaotong University pays non établi dans la noticeUniversité ou école supérieure
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Clinical Psychology Department of Xi'an Gaoxin Hospital pays non établi dans la noticeÉtablissement de santé
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The Fifth Hospital of Yulin pays non établi dans la noticeÉtablissement de santé
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Weiqu Subdistrict Central Health Center of Chang'an District pays non établi dans la noticeÉtablissement de santé
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College of Medicine & Forensics pays non établi dans la noticeUniversité ou école supérieure
Department of Psychiatry — First Affiliated Hospital of Xi'an Jiaotong University, Yulin University et Center for Forensic Mental Health — Chiba University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.