Accès ouvert
2026
article
OpenAlex
Mateusz Czajkowski, Marcin Falis, Jan Mandrysz, Oliwia Kozak et autres
Background/Objectives: Histopathology-correlated evidence for preoperative magnetic resonance imaging (MRI) in penile cancer remains limited. We evaluated multiparametric MRI with artificially induced erection for local and nodal staging in surgically treated penile cancer. Methods: This prospective, single-centre diagnostic accuracy study included consecutive patients …
pl, de
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Accès ouvert
2026
article
OpenAlex
Piotr Wierzbicki, Agnieszka Rybarczyk, Mateusz Czajkowski, Jacek Kieżun et autres
Clear-cell renal cell carcinoma (ccRCC) is characterised by constitutive activation of hypoxia-inducible factors (HIFs) following VHL loss, which contributes to tumour progression and therapeutic resistance. Given the limitations of VEGFR-targeted therapies, we investigated the biological and potential therapeutic relevance of the HIF …
pl, br
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Accès ouvert
2025
article
OpenAlex
Michalina Grudzińska, Mateusz Czajkowski, Maciej Dolny, Marcin Matuszewski et autres
Background/Objectives: Penile squamous cell carcinoma (PSCC) is rare but aggressive. Systemic chemotherapy plays a crucial role in the management of node-positive or metastatic cases; however, the supporting evidence predominantly originates from small, non-randomized studies. This review provides a narrative analysis of the …
pl, de
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Accès ouvert
2025
article
OpenAlex
Mateusz Czajkowski, Marcin Falis, Agata Błaczkowska, Agnieszka Rybarczyk et autres
Background: Penile cancer is an uncommon malignancy in European and North America countries, accounting for less than 1% of malignant neoplasms. The etiology of penile cancer involves a complex interplay of clinical and behavioral factors, including phimosis, smoking, excess body weight, and …
pl, de
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Accès ouvert
2023
article
OpenAlex
Anna Piotrowska, Agnieszka Rybarczyk, Piotr Wierzbicki, Marzena Kotwas et autres
Introduction. In the early 1990s, during experiments aimed at intensifying the colour of Petunia hybryda flowers, a new mechanism of regulation of gene expression was discovered; however, its mechanism, i.e. inhibition of gene expression at a post-transcriptional stage, remained unknown. In 1998 …
pl
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Accès ouvert
2022
article
OpenAlex
Anna Kotulak‐Chrząszcz, Agnieszka Rybarczyk, Jakub Kłącz, Marcin Matuszewski et autres
Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of kidney cancer, with high mortality rates worldwide. The sonic hedgehog (SHH) molecular cascade is altered in various malignancies in tumorigenesis, and several SHH pathway inhibitors have been considered …
pl
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Accès ouvert
2019
article
OpenAlex
Piotr Wierzbicki, Jakub Kłącz, Anna Kotulak‐Chrząszcz, Agata Wrońska et autres
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell cancer, characterized by the highest mortality rate among other RCC subtypes due to the occurrence of metastasis and drug resistance following surgery. The Von Hippel‑Lindau tumor suppressor (VHL)‑hypoxia‑inducible …
pl
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Accès ouvert
2019
article
OpenAlex
Anna Piotrowska, Justyna Wierzbicka, Agnieszka Rybarczyk, Robert Charles Tuckey et autres
Melanoma represents a significant challenge in cancer treatment due to the high drug resistance of melanomas and the patient mortality rate. This study presents data indicating that nanomolar concentrations of the hormonally active form of vitamin D, 1α,25‑dihydroxyvitamin D3 [1α,25(OH)2D3], its non‑calcemic …
pl, au, us
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2017
article
OpenAlex
Agnieszka Rybarczyk, Jakub Kłącz, Agata Wrońska, Marcin Matuszewski et autres
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC (70-80%). Yes-associated protein 1 (YAP1) protein is a nuclear effector of the Hippo pathway and acts as a transcriptional co-activator of genes involved in the processes of growth and …
pl
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Accès ouvert
2015
article
OpenAlex
Jakub Kłącz, Agata Wrońska, Agnieszka Rybarczyk, Marcin Stanisławowski et autres
Clear-cell renal cell carcinoma (ccRCC) is the most common subtype of RCC (70-80%) and is associated with poor prognosis in 40% of cases mainly due to metastasis in the course of the disease. RASSF1, with its isoforms RASSF1A and RASSF1C, is a …
pl
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Accès ouvert
2015
article
OpenAlex
Agnieszka Rybarczyk
Colorectal cancer (CRC) is one the most frequently diagnosed neoplastic diseases worldwide. Currently, aside from traditional chemotherapy, advanced CRCs are treated with modern drugs targeting cellular components such as epithelial growth factor receptor (EGFR). Since up to 70% of metastasized CRCs are …
pl
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Accès ouvert
2014
article
OpenAlex
Marzena Kogut-Wierzbicka, Jarosław Ruczyński, Kamila Siedlecka-Kroplewska, Lucyna Kaszubowska et autres
INTRODUCTION: Cell penetrating peptides (CPPs) have the ability to translocate through cell membranes with high efficiency and therefore can introduce biological agents with pharmaceutical properties into the cell. Transportan (TP) and its shorter analog transportan 10 (TP10) are among the best studied …
pl
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