Sarah A. Milgrom

Consensus radiation therapy organ at risk constraints for NCTN trials in hematologic malignancies

Austin J. Sim, Bradford S. Hoppe, Leslie K Ballas, Sarah A. Milgrom et autres

Modern radiation therapy (RT) technologies allow for improved sparing of normal tissues, decreasing the risk of both acute and long-term toxicities. Existing RT dose constraints for prospective trials within the National Clinical Trials Network (NCTN) were formulated in the context of solid …

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Executive Summary of the American Radium Society Appropriate Use Criteria for Extranodal Natural Killer/T-cell Lymphoma

Savita Dandapani, Sairah Ahmed, Timothy Robinson, Ranjana Advani et autres

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Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) Into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report From the National Clinical Trials Network

Nataliya Kovalchuk, Eric Simiele, Michael J. LaRiviere, Susan M. Hiniker et autres

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Coronary Atherosclerosis in Patients With Cancer and Survivors: A Scientific Statement From the American Heart Association

Lili Zhang, Cezar Iliescu, Maros Ferencik, Victoria Finamore et autres

There is an emerging convergence between atherosclerotic cardiovascular disease and cancer, driven by shared risk factors and overlapping pathophysiologic mechanisms. Traditional factors, such as smoking, aging, obesity, hypertension, and diabetes, alongside novel markers, such as clonal hematopoiesis of indeterminate potential, not only …

Subsequent Neoplasm Risk After Modern Mediastinal Radiation Therapy for Pediatric Hodgkin Lymphoma: Insights From a Multi-Institutional Children’s Oncology Group Trial

Sarah A. Milgrom, Harald Paganetti, Hitesh Dama, Lindsay Renfro et autres

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Imaging pitfalls in pediatric, adolescent, and young adult Hodgkin lymphoma: a SEARCH for CAYAHL initiative to bridge multidisciplinary patient care

Nawar Dakhallah, Jonas Steglich, Claire Gowdy, Sarah A. Milgrom et autres

Pediatric Hodgkin lymphoma (pHL) is a highly curable malignancy in children, adolescents, and young adults, and current treatment strategies aim to minimize adverse late effects. Many patients are enrolled in clinical trials with centralized review for both initial and interim staging. Although …

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Prognostic role of PET / CT volumetric parameters in paediatric Hodgkin lymphoma: A systematic review and expert recommendations from the International SEARCH for CAYAHL Group

S. Claire Gowdy, Jamie E. Flerlage, Jennifer Seelisch, Monica Palese et autres

Summary In adults with classic Hodgkin lymphoma (cHL), metabolic tumour volume (MTV) is valuable for risk stratification. This systematic review explored the role of volumetric parameters in children, adolescents and young adults (CAYA) with cHL. This systematic review was performed according to …

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Enhancing Radiation Therapy Quality Assurance in Lymphoma: A Rigorous Real-Time Central Review Process in AHOD2131

Andrea Lo, Sarah A. Milgrom, Raymond Mailhot Vega, David Hodgson et autres

Although radiation therapy quality assurance (RTQA) is important in any clinical trial with a radiation therapy (RT) component, it is paramount in lymphoma trials for several reasons. As lymphoma RT has evolved to use smaller and more complex treatment fields such as …

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Multimodality Artificial Intelligence for Involved-Site Radiation Therapy: Clinical Target Volume Delineation in High-Risk Pediatric Hodgkin Lymphoma

Xin Tie, Sarah A. Milgrom, Andrea Lo, Anne-Marie Charpentier et autres

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Enhancing Radiotherapy Quality Assurance in Lymphoma: A Rigorous Real-Time Central Review Process in AHOD2131

Andrea Lo, Sarah A. Milgrom, Raymond B. Mailhot Vega, Darren Hodgson et autres

Introduction Radiation therapy quality assurance (RTQA) is essential in clinical trials to ensure protocol-compliant treatment. As lymphoma radiotherapy (RT) has evolved to use smaller volumes and more conformal techniques, treatment planning has become increasingly complex, requiring a rigorous RTQA process. We report …

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Multi-modality Artificial Intelligence for Involved-Site Radiation Therapy: Clinical Target Volume Delineation in High-Risk Pediatric Hodgkin Lymphoma

Xin Tie, Sarah A. Milgrom, Andrea Lo, AM Charpentier et autres

Introduction Clinical target volume (CTV) delineation for involved-site radiation therapy (ISRT) in Hodgkin lymphoma (HL) is time-consuming due to the need to analyze multi-time-point PET/CT scans co-registered to the planning CT. Deep learning (DL) has the potential to streamline this task, but …

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Predicted Breast Cancer Risk after Mediastinal Radiotherapy for Pediatric Hodgkin Lymphoma: Analysis of a Multi-Institutional Children’s Oncology Group Trial

Sarah A. Milgrom, Harald Paganetti, Hitesh Dama, Lindsay A. Renfro et autres

Introduction There are limited data regarding the risk of breast cancer (BrCa) following contemporary involved site radiation therapy (ISRT) for pediatric Hodgkin Lymphoma (HL). We sought to quantify this risk and identify factors associated with breast dose and subsequent BrCa risk. Methods …

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