Eric Simiele

Incorporating Intensity Modulated Total Body Irradiation (IMRT-TBI) Into Future Cooperative Group Clinical Trials: An NRG Hematologic Malignancies Working Group-Led Report From the National Clinical Trials Network

Nataliya Kovalchuk, Eric Simiele, Michael J. LaRiviere, Susan M. Hiniker et autres

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Intensity-Modulated Total-Body Irradiation

Eric Simiele, Chunhui Han, Nataliya Kovalchuk

Total-body irradiation (TBI) is an important component of myeloablative and non-myeloablative conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT). Historically, 2D treatment techniques were utilized to irradiate the entire body to the prescription dose. Technological advancements in radiotherapy planning and delivery …

The Spinning Manny Indexed Overlay System for VMAT total body irradiation

Lawrie Skinner, Eric Simiele, Zi Yang, Caressa Hui et autres

PURPOSE: While modern intensity-modulated techniques for total body irradiation (TBI) offer superior organ sparing and improved dose coverage compared to conventional TBI, their complexity has limited widespread adoption. Specifically, when treating individuals with Volumetric Modulated Arc Therapy (VMAT-TBI), a transition between the …

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Brachytherapy Measurement Standards

Samantha J. Simiele, Christopher J. Tien, Eric Simiele

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Using an Auto-Planned VMAT-TBI Technique for Myeloablative Autologous Hematopoietic Stem Cell Transplantation for Scleroderma (The STAT-2 Trial)

Caressa Hui, Ignacio O. Romero, Eric Simiele, Sally Arai et autres

Abstract Objectives The STAT-2 trial mandates lung and kidney sparing to 25% of the prescription dose and image guidance for kidney localization, posing challenges for institutions using conventional two-dimensional (2D) Total body irradiation (TBI) techniques. This study demonstrates implementation of an auto-planned …

Automated contouring, treatment planning, and quality assurance for total marrow lymphoid irradiation

Eric Simiele, Caressa Hui, Ignacio A. Romero, Zi Yang et autres

Purpose: Total marrow and lymphoid irradiation (TMLI) enables dose escalation to targets while minimizing exposure to surrounding organs at risk (OARs), but its clinical implementation is complex. To simplify this process, contouring, treatment planning, and physics plan checks were automated, and the …

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Implementing Advanced Total Body Irradiation (TBI) Techniques into Clinical Trials: An NRG Hematologic Malignancies Working Group Survey

Nataliya Kovalchuk, Eric Simiele, M.J. LaRiviere, Susan M. Hiniker et autres

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A Single Automated VMAT Planning Framework for TBI, CSI and TMLI: Streamlining Workflow and Enhancing Plan Quality

Eric Simiele, Ignacio O. Romero, Caressa Hui, M.S. Binkley et autres

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The use of transrectal ultrasound to improve gynecologic interstitial applicator implantation

Joel A. Pogue, Eric Simiele, Samantha J. Simiele, M. Soike et autres

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A retrospective look at the use of a commercial daily quality assurance device for a proton therapy beam

J. K. Kraus, Joseph Harms, Kristen McConnell, Eric Simiele et autres

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RefleXion X1 Treatment Planning Feasibility Study for Craniospinal Irradiation (CSI)

Tracy Ngo, Daniel Pham, Ignacio O. Romero, Eric Simiele et autres

Abstract Objective: The first clinical biology-guided radiation therapy system, RefleXion X1, was commissioned for clinical use at our institution. This study evaluates the X1 treatment planning feasibility of complex craniospinal targets for pediatric medulloblastoma patients and compares plan quality to multi-isocenter linac-based …

Radiation as an Immune Modulator: Where We Are With Modern Total Body Irradiation

Eric Simiele, Savita Dandapani, Chunhui Han, Jeffrey Wong et autres

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