Sang‐Moo Kang

Early life respiratory syncytial virus infection enhances cadmium-induced lung toxicity through protein S-palmitoylation

Jennifer Jeon, Choon‐Myung Lee, Ho Young Lee, Zachery R Jarrell et autres

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Saponin derivative and MPLA-adjuvanted intranasal protein nanoparticle vaccines induce potent mucosal immunity and durable heterologous influenza protection in mice

Lai Wei, Wandi Zhu, Chunhong Dong, Joo Kyung Kim et autres

us, ca (code pays fourni par la source)

Single-cell RNA sequencing reveals dysregulation of innate immune signaling in early-life respiratory syncytial virus infection with subsequent low-level cadmium exposure

Zachery R Jarrell, Ho Young Lee, Jennifer Jeon, Gahyun Lim et autres

ABSTRACT Early-life respiratory syncytial virus infection (eRSV) causes severe respiratory illness in vulnerable populations and has a significant global health burden. eRSV-associated pathologies are exacerbated by low levels of cadmium (Cd) in the diet, leading to increased cytokine and chemokine levels, inhibited …

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Mechanisms of mRNA lipid nanoparticle vaccines in enhancing the immunogenicity of conventional influenza and protein subunit vaccines 2253125

Sang‐Moo Kang, Chau Thuy Tien Le, Phillip Grovenstein, Mahmuda Yeasmine et autres

Abstract Introduction Lipid nanoparticles (LNP) used for mRNA vaccine delivery are known to be inflammatory at high doses. Here, we hypothesized that co-immunization with low-dose mRNA-LNP and conventional influenza or protein subunit vaccine would stimulate a unique set of innate responses, correlating …

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Influenza mRNA-LNP vaccines enhance the immunogenicity of protein-based influenza subunit and inactivated split vaccines after co-administration 2253871

Phillip Grovenstein, Mahmuda Yeasmin, Chau Thuy Tien Le, Ki‐Hye Kim et autres

Abstract Introduction Current commercially available split inactivated (split) influenza vaccines offer suboptimal protection, highlighting the need for broader and more durable influenza vaccination strategies. We hypothesized that cross-protective influenza mRNA vaccines would enhance the immunogenicity of influenza split and protein-based vaccines via …

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Mosaic Inverted Hemagglutinin Extracellular Vesicle Vaccines Elicit Protective Systemic and Mucosal Immunity against Heterosubtypic Influenza Infection

Wandi Zhu, Lai Wei, Chunhong Dong, Joo Kyung Kim et autres

Developing innovative vaccine platforms and delivery strategies to induce broad, protective immunity in the respiratory tract is crucial for preventing influenza infection and transmission in potential epidemics and pandemics. In this study, we used cell-derived extracellular vesicles (EVs) as a vaccine platform …

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Type I interferon signaling is required for resistance to primary influenza virus infection and vaccine-induced long-term immunity

Ki-Hye Kim, Hye Suk Hwang, Surya Sekhar Pal, Chau Thuy Tien Le et autres

Type I interferons (IFNs) are critical for early antiviral defense, yet their role in shaping vaccine-induced immunity remains incompletely understood. Here, we investigated the impact of type I IFN receptor (IFNαβR) deficiency on immune responses to influenza virus infection and vaccination in …

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Low-dose multivalent COVID-19 mRNA vaccines enhance broadly cross-reactive antibodies and protective immune responses of co-administered protein-based vaccines

Rong Liu, Lila D. Patterson, Mahmuda Yeasmin, Ki‐Hye Kim et autres

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Intranasal Delivery of an RSV A2-Derived Pre-F VLP Vaccine Induces Robust Mucosal and Systemic Immunity Against RSV B Strain Without Enhanced Disease

Arun Meas, Young Hun Kim, Su Jeong Leem, Karmina Barrogoa et autres

Respiratory syncytial virus (RSV) is a contagious pathogen that infects respiratory epithelial cells and causes serious lower respiratory diseases in young children and the elderly. In this study, we evaluated the cross-protective efficacy of intranasally administered virus-like particles (VLPs) expressing the prefusion …

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A combination of new prefusion mRNA and protein vaccines enhances neutralizing antibodies and protection against respiratory syncytial virus

Surya Sekhar Pal, Ki-Hye Kim, Noopur Bhatnagar, Phillip B Grovenstein et autres

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Environmental cadmium exposure following respiratory syncytial virus infection stimulated lung inflammation and disrupted essential metal homeostasis 2326

Young-Mi Go, Zachery Ryan Jarrell, Ki‐Hye Kim, Dean P. Jones et autres

Abstract Description Cadmium (Cd) accumulates in humans due to dietary, environmental exposure and occupational sources, and has a long biological half-life. Most individuals have pre-existing immunity from early-life exposure to respiratory syncytial virus (RSV), which causes serious lung disease and hospitalizations among …

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Interferon-γ receptor signaling is critical for balanced immune activation and protection against influenza after vaccination

Ki‐Hye Kim, Hye Suk Hwang, Youri Lee, Yu‐Jin Jung et autres

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