Ki‐Hye Kim

Mechanisms of mRNA lipid nanoparticle vaccines in enhancing the immunogenicity of conventional influenza and protein subunit vaccines 2253125

Sang‐Moo Kang, Chau Thuy Tien Le, Phillip Grovenstein, Mahmuda Yeasmine et autres

Abstract Introduction Lipid nanoparticles (LNP) used for mRNA vaccine delivery are known to be inflammatory at high doses. Here, we hypothesized that co-immunization with low-dose mRNA-LNP and conventional influenza or protein subunit vaccine would stimulate a unique set of innate responses, correlating …

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Influenza mRNA-LNP vaccines enhance the immunogenicity of protein-based influenza subunit and inactivated split vaccines after co-administration 2253871

Phillip Grovenstein, Mahmuda Yeasmin, Chau Thuy Tien Le, Ki‐Hye Kim et autres

Abstract Introduction Current commercially available split inactivated (split) influenza vaccines offer suboptimal protection, highlighting the need for broader and more durable influenza vaccination strategies. We hypothesized that cross-protective influenza mRNA vaccines would enhance the immunogenicity of influenza split and protein-based vaccines via …

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Low-dose multivalent COVID-19 mRNA vaccines enhance broadly cross-reactive antibodies and protective immune responses of co-administered protein-based vaccines

Rong Liu, Lila D. Patterson, Mahmuda Yeasmin, Ki‐Hye Kim et autres

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Environmental cadmium exposure following respiratory syncytial virus infection stimulated lung inflammation and disrupted essential metal homeostasis 2326

Young-Mi Go, Zachery Ryan Jarrell, Ki‐Hye Kim, Dean P. Jones et autres

Abstract Description Cadmium (Cd) accumulates in humans due to dietary, environmental exposure and occupational sources, and has a long biological half-life. Most individuals have pre-existing immunity from early-life exposure to respiratory syncytial virus (RSV), which causes serious lung disease and hospitalizations among …

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Interferon-γ receptor signaling is critical for balanced immune activation and protection against influenza after vaccination

Ki‐Hye Kim, Hye Suk Hwang, Youri Lee, Yu‐Jin Jung et autres

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Intranasal vaccination with multi-neuraminidase and M2e virus-like particle vaccine results in greater mucosal immunity and protection against influenza than intramuscular injection

Jannatul Ruhan Raha, Ki‐Hye Kim, Chau Thuy Tien Le, Noopur Bhatnagar et autres

Intramuscular injection of seasonal influenza vaccines provides strain-specific neutralizing antibodies, but not against variants, and no effective mucosal immunity. Here, we report that multi-subtype neuraminidase (NA) and M2 ectodomain repeat (5xM2e) virus-like particle vaccine (NA-M2e) conferred higher efficacy of broad cross-protection after …

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Dual roles of influenza B virus neuraminidase mRNA vaccine in enhancing cross-lineage protection by supplementing inactivated split vaccination

Chau Thuy Tien Le, Ki‐Hye Kim, Jannatul Ruhan Raha, Noopur Bhatnagar et autres

The current influenza vaccine is based on immunity to hemagglutinin (HA) and provides poor cross-protection. Here, we generated mRNA vaccine encoding influenza B virus (IBV) neuraminidase (NA) conjugated to influenza A virus M2 ectodomain (M2e), encapsulated in lipid nanoparticles (LNP), capable of …

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Cadmium exposure following early-life respiratory syncytial virus infection promotes lung fibrosis through autophagy inhibition

Zachery Ryan Jarrell, Choon‐Myung Lee, Ho Young Lee, Ki‐Hye Kim et autres

Early-life respiratory syncytial virus (RSV) infection (eRSV) is a major cause of severe respiratory illness in children and increases the risk of asthma and lung dysfunction later in life. Cadmium (Cd), a toxic environmental metal, exacerbates these risks when combined with eRSV. …

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A strategy of enhancing the protective efficacy of seasonal influenza vaccines by providing additional immunity to neuraminidase and M2e

Jannatul Ruhan Raha, Ki‐Hye Kim, Chau Thuy Tien Le, Noopur Bhatnagar et autres

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Influenza 5xM2e mRNA lipid nanoparticle vaccine confers broad immunity and significantly enhances the efficacy of inactivated split vaccination when coadministered

Phillip B Grovenstein, Noopur Bhatnagar, Ki‐Hye Kim, Surya Sekhar Pal et autres

Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from …

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Non-neutralizing immune-mediated cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets

Sang‐Moo Kang, Ki‐Hye Kim, Noopur Bhatnagar, Rong Liu et autres

Abstract Current influenza vaccine based on hemagglutinin (HA) immunity is not effective in providing cross protection against circulating variants and new pandemic viruses. In prior studies, we developed universal influenza vaccine candidates of multi-subtype neuraminidase and M2 ectodomain virus-like particles (m-cNA-M2e VLP) …

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Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets

Ki‐Hye Kim, Noopur Bhatnagar, Rong Liu, Surya Sekhar Pal et autres

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