Andrei Alimov

Preclinical characteristics of siRNA duplexes as targeted adjuvants in malignant growth

H. M. Treshalina, Galina B. Smirnova, A. Yu. Kuzevanova, Saida Sh. Karshieva et autres

Background. Small or short double-stranded interfering RNAs (siRNAs, small interfering RNAs) 20–25 nucleotides long are known to be able to target block uncontrolled malignant proliferation. As target genes, apoptosis inhibitors are considered, including the cellular glycoprotein CD47 (cluster of differentiation 47), and …

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Phylogenetic relationships of ATM polymorphic loci haplotypes in Eurasian and African populations

M. V. Olkova, Sergey Koshel, GYu Ponomarev, Andrei Alimov

ABSTRACT The ATM gene encodes a key kinase involved in DNA repair and cell cycle control, and mutations in it lead to the development of ataxia-telangiectasia and increase susceptibility to cancer. In this context, the study of the distribution patterns of ATM …

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Comparative Analysis of Quantitative Indicators of Progesterone Receptor Protein and mRNA Expression in Tumor Cell Lines.

I. P. Romanov, Т. А. Богуш, Andrei Alimov, A. Yu. Kuzevanova et autres

Progesterone receptors are involved in the regulation of tumor cell proliferation and therefore can be considered as a target of antitumor drugs. However, the question of the concordance of quantitative indicators of the protein and mRNA produced as a result of the …

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Comparative analysis of quantitative indicators of progesterone receptor protein and mRNA expression in tumor cell lines

I. P. Romanov, Т. А. Богуш, Andrei Alimov, A. Yu. Kuzevanova et autres

STABILITY OF TRANSCRIPTS ENCODING IMMUNOPHILINS

Andrei Alimov

We thank all participants of our conference "Scientific research of the SCO countries: synergy and integration" for the interest shown, for your speeches and reports.Such a wide range of participants, representing all the countries that are members of the Shanghai Cooperation Organization, …

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The two types of immune microenvironment of renal cancer

А. А. Борунова, Andrei Alimov, И. Б. Шоуа, А. И. Черткова et autres

Background. The tumor microenvironment can both restrain tumor growth and promote disease progression. Therefore, the study of tumor-infiltrating lymphocytes (TILs) subpopulation composition is an urgent and significant topic.Aim. To characterize the immune microenvironment of renal cancer by flow cytometry.Materials and methods. The …

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Personalized assessment of the effectiveness of targeted drugs for the treatment of cystic fibrosis in a patient with c.264_268delATATT and c.3139+1G>C rare variants of the CFTR gene

Anna Efremovа, V. Sherman, Y. Melyanovskaya, Diana Mokrousova et autres

BACKGROUND: When new, most often rare CFTR gene variants, are detected in patients with cystic fibrosis, intestinal organoids are used, which allows for the assessment of the residual functional activity of the CFTR channel and the effect of targeted drugs to determine …

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Immune checkpoints PD-1/PD-L1 and TIM-3/GAL-9 and prospects for their simultaneous inhibition

Ф. М. Кипкеева, Danzan Mansorunov, Т. А. Музаффарова, Н. В. Апанович et autres

В настоящее время широкое распространение в клинической практике получили препараты, нацеленные на ингибирование иммунных контрольных точек (ИКТ). Однако для значительной группы больных монотерапия ингибитором ИКТ не является эффективной. Одна из причин этого кроется в сложном механизме взаимодействия между рядом белков, являющихся рецепторами …

Molecular characteristics of non-small cell lung cancer tissue based on quantitative indicators of progesterone receptors expression

I. P. Romanov, Т. А. Богуш, Alexander M. Scherbakov, Andrei Alimov et autres

Background. Progesterone receptors (PR) are regulators of cell proliferation and therefore can be considered as an aim for targeted medications in the treatment of oncological diseases. At the same time, a quantitative assessment of PR expression in the tissue of non-small cell …

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Association of immune checkpoint ligand gene expression with postoperative survival in gastric cancer

Danzan Mansorunov, Ф. М. Кипкеева, М. П. Никулин, Andrei Alimov

ФУНДАМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ И МЕЖДИСЦИПЛИНАРНЫЕ ТЕХНОЛОГИИ ■ Резюме Экспрессия ингибиторных лигандов и рецепторов иммунных контрольных точек в опухоли, как правило, ассоциирована с опухолевой прогрессией, а уровень экспрессии также может рассматриваться в качестве прогностического маркера.Цель -изучение ассоциации экспрессии генов ингибиторных лигандов иммунных контрольных точек …

Expression of immune checkpoint genes during kidney cancer progression

П. В. Апанович, Oybek Khalmurzaev, В. Б. Матвеев, Andrei Alimov

Светлоклеточный почечно-клеточный рак (скПКР) является наиболее распространенным и агрессивным гистологическим подтипом почечно-клеточного рака. На момент постановки диагноза у трети больных имеют место отдаленные метастазы. Значительный прогресс в лечении метастатического рака почки достигнут с началом применения таргетной терапии и терапии ингибиторами иммунных контрольных …

Features of Distribution of the Allelic Variant of the OAS1 Gene Associated with Severe Form of the Coronavirus Infection in the Russian and Global Populations

M. V. Olkova, Sergey Koshel, В. С. Петрушенко, Andrei Alimov

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