Accès ouvert déclaré 2025 article

Assessment of the mild behavioral impairment checklist in individuals with subjective cognitive decline and mild cognitive impairment in the BRASCODE cohort

Victória Tizeli Souza, Bárbara Loeblein Uebel, Gabriela Raquel Paz Rivas, Simone Sieben da Mota, Bruno de Oliveira De Marchi, Guilherme Da Silva Carvalho, Haniel Bispo De Souza, Lucas Bastos Beltrami, Rhaná Carolina Santos, Sarah Vitória Bristot Carnevalli, Ana Letícia Amorim de Albuquerque, Leonardo Martins de Paula, Manuella Edler Zandoná Giordani, Wyllians Vendramini Borelli, Giovanna Carello‐Collar, Marcia L. Fagundes Chaves, Eduardo R. Zimmer, Raphael Machado Castilhos

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Le résumé fourni par la source

BACKGROUND: Mild Behavioral Impairment (MBI) is characterized by neuropsychiatric symptoms that may precede cognitive decline in the early stages of neurodegenerative diseases. In Brazil, the study of MBI in individuals with cognitive complaints remains limited. This study aims to evaluate the MBI-Checklist (MBI-C) in individuals with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI) in the Brazilian Subjective Cognitive Decline (BRASCODE) cohort in southern Brazil. METHODS: Cognitively unimpaired adults >65 years old with cognitive complaints, but no severe clinical or neuropsychiatric illness, are enrolled in the BRASCODE cohort. This analysis includes data from participants who completed the 12-month follow-up. The applied scales included: Mild Behavioral Impairment Checklist (MBI-C) and Memory Complaint Scale (MCS) (participant and informant); Neuropsychiatric Inventory-Questionnaire (NPI-Q) (informant); Geriatric Depression Scale (GDS), Geriatric Anxiety Inventory (GAI), Mini-Mental State Examination (MMSE) (participant); and Clinical Dementia Rating (CDR). We performed a correlation analysis between continuous variables. We considered a p-value < 0.05 as statistically significant. RESULTS: A total of 100 participants completed the 12-month follow-up, of whom 13 were diagnosed with MCI. Table 1 presents demographic and clinical characteristics. MBI-C participant scores correlated positively with depressive (GDS, rho = 0.695, p < 0.0001) and anxiety symptoms (GAI, rho = 0.519, p < 0.0001). MBI-C informant scores showed a strong correlation with NPI-Q (rho = 0.743, p < 0.0001) and the informant's perception of cognitive decline (rho = 0.364, p = 0.0004). A significant correlation was also found between MBI-C informant scores and CDR-SOB (rho = 0.283, p = 0.007). Additionally, MBI-C participant scores were negatively correlated with formal education (rho = -0.387, p = 0.009). No significant correlation was found between MBI-C-participant and MBI-informant scores. CONCLUSION: The MBI-C identified neuropsychiatric symptoms in individuals with SCD and MCI, showing a strong correlation with anxiety and depressive symptoms. Additionally, MBI-C-informant scores were significantly correlated with neuropsychiatric symptoms and cognitive impairment measures. These findings bring attention to the relevance of MBI-C in the behavioral assessment of this population. Research with larger samples is needed to better understand the associations between MBI and cognitive decline in individuals with SCD and MCI.

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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Assessment of the mild behavioral impairment checklist in individuals with subjective cognitive decline and mild cognitive impairment in the BRASCODE cohort
Date Crossref: 01/12/2025
Éditeur: Wiley
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Universidade Federal do Rio Grande do Sul pays non établi dans la notice
Université ou école supérieure
Hospital de Clínicas de Porto Alegre pays non établi dans la notice
Établissement de santé
Universidade do Vale do Rio dos Sinos pays non établi dans la notice
Université ou école supérieure
Universidade Federal de Santa Catarina pays non établi dans la notice
Université ou école supérieure
Instituto do Cérebro pays non établi dans la notice
Organisation à but non lucratif
Hospital Moinhos de Vento Centro de Memória pays non établi dans la notice
Établissement de santé
Pontifícia Universidade Católica do Rio Grande do Sul pays non établi dans la notice
Université ou école supérieure
McGill University pays non établi dans la notice
Université ou école supérieure
Federal University of Rio Grande do Sul pays non établi dans la notice
Université ou école supérieure
Brain Institute of Rio Grande do Sul (InsCer) pays non établi dans la notice
Structure de recherche
Clinical Hospital of Porto Alegre pays non établi dans la notice
Établissement de santé
UFRGS pays non établi dans la notice
Institution

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre et Universidade do Vale do Rio dos Sinos, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Dementia and Cognitive Impairment ResearchNeurological Disorders and TreatmentsCognitive Functions and Memory

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