Accès ouvert
2026
article
OpenAlex
Rangsima Ponvattanaporn, Jeremy P. Le, Z S Li, Ryan J.D. Rivero et autres
Methylglyoxal (MG) is a small and highly reactive byproduct of multiple metabolic reactions. In mammalian cells, MG serves important roles in cell signaling, but elevated levels of MG are toxic and contribute to the progression of many diseases, including autoimmune conditions and …
au, ca
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Zahra Omole, Subhadeep Gupta, Maria Webster, Janie Liaw et autres
Abstract Campylobacter jejuni is a leading global cause of acute foodborne gastroenteritis however, C. jejuni lacks some of the classic virulence determinants associated with other common enteric bacterial pathogens. In recent years an increasing number of C. jejuni isolates have been identified …
gb, jp, in, au
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Warasinee Mujchariyakul, Calum J. Walsh, Stefano G. Giulieri, Cameron Cramond et autres
ABSTRACT Bloodstream infections caused by Staphylococcus aureus remain a leading cause of mortality worldwide. Our understanding of S. aureus survival and persistence in human serum, a cell-free fraction of blood hostile for bacteria, is still limited. Here, we applied multivariate data integration …
au, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jieru Deng, Yuting Yan, Calum J. Walsh, Emmanuel Montassier et autres
Mucosal-associated invariant T cells (MAIT cells) mediate tissue homeostasis and antimicrobial immunity. However, the cells that express major histocompatibility complex (MHC) class I-related protein 1 (MR1) and present microbial vitamin B-derived antigens (VitBAg) to MAIT cells remain unknown. We found that MR1 …
au, cn, fr, ca
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Warasinee Mujchariyakul, Abderrahman Hachani, Timothy P. Stinear, Kim‐Anh Lê Cao et autres
Abstract The increasing availability of microbial multi-omics datasets has created new opportunities to explore complex biological systems. However, exploration remains limited by the lack of accessible, reproducible workflows that integrate multiple omics layers and deliver easily interpretable visualisations of functional and pathway-level …
au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Sarah L. Harbach, Bang M. Tran, Abderrahman Hachani, Samantha L. Grimley et autres
COVID-19 has triggered the rapid adoption of human organoid-based tissue culture models to overcome the limitations of the commonly used Vero cell line that did not fully recapitulate SARS-CoV-2 infection of human tissues. As the primary site of SARS-CoV-2 infection, the human …
au
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Warasinee Mujchariyakul, Calum J. Walsh, Stefano G. Giulieri, Cameron Cramond et autres
ABSTRACT Bloodstream infections caused by Staphylococcus aureus remain a leading cause of mortality worldwide. Our understanding of S. aureus survival and persistence in human serum, a cell-free fraction of blood hostile for bacteria, is still limited. Here, we applied multivariate data integration …
au
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri et autres
Staphylococcus aureus is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, S. aureus must undergo substantial metabolic adaptation to achieve persistent infection in the distinctive microenvironment of the …
us, cn, au, se, ca, in
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Romain Guérillot, Ashleigh S. Hayes, Abderrahman Hachani, Stefano G. Giulieri et autres
Abstract Understanding Staphylococcus aureus adaptation is foundational for addressing the challenges posed by this pathogen. Using evolutionary convergence analysis on 7099 S. aureus genomes we uncovered frequent, reversible loss-of-function (LoF) mutations caused by simple sequence repeats (SSRs). Functional assays showed SSRs are …
au
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Maria Gonzalez-Nuñez, Luiz Ricardo C. Vasconcellos, José Garrido‐Mesa, Rafael Cardoso Maciel Costa Silva et autres
Abstract Phosphoinositide 3-kinase delta (PI3Kδ) is essential for immune cell functions, preventing immunodeficiency and inflammation; however, its role in dendritic cell (DC)-mediated immune regulation remains unknown. Here, we report a key role for DC-intrinsic PI3Kδ in linking microbial recognition with antigen presentation …
gb, es, br, au, it, sg, fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Ying-Tsun Chen, Zihua Liu, Dario Fucich, Stefano G. Giulieri et autres
Abstract Staphylococcus aureus is a leading cause of healthcare-associated pneumonia, contributing significantly to morbidity and mortality worldwide. As a ubiquitous colonizer of the upper respiratory tract, S. aureus must undergo substantial metabolic adaptation to achieve persistent infection in the distinctive microenvironment of …
us, cn, au, se, ca, in
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Pauline M. L. Coulon, Marie‐Christine Groleau, Abderrahman Hachani, Matthew Paul Padula et autres
ABSTRACT Phenotypic diversity in bacteria often results from adaptation to changing environmental conditions, exemplified by variable colony morphotypes. In Burkholderia pseudomallei , discrete genomic alterations and modulation of gene expression facilitate adaptation. Adapted variants of species within the Burkholderia cepacia complex (Bcc) …
au, ca, gb
(code pays fourni par la source)