SK Parsons

Blinatumomab Care Delivery for Pediatric B-Cell Acute Lymphoblastic Leukemia

Daniel J. Zheng, Katelyn Oranges, Subhash Ramakrishnan, Lingyun Ji et autres

Importance: Blinatumomab, a novel immunotherapy administered as a 28-day continuous infusion, has fundamentally shifted the treatment paradigm for pediatric B-cell acute lymphoblastic leukemia (B-ALL) and is now considered a component of standard therapy for the most common childhood cancer. However, the care …

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Validation of the advanced‐stage Hodgkin lymphoma international prognostic index (A‐HIPI) in the GHSG HD21 trial

Hishan Tharmaseelan, Janina Jablonski, SK Parsons, Angie Mae Rodday et autres

The International Prognostic Score (IPS) has served as the standard risk stratification tool in advanced-stage classical Hodgkin Lymphoma (cHL) for over two decades. 1 The IPS-7 incorporates seven dichotomized clinical factors-age, sex, serum albumin, hemoglobin, Ann Arbor stage, leukocytosis, and lymphocytopenia-to assign …

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Transforming lymphoma outcomes through international real-world data collaborations: the Global Lymphoma Registry Alliance roadmap

Eliza A. Hawkes, Eliza Chung, Mark Bishton, Natacha Bolaños et autres

Lymphomas comprise a complex and heterogeneous group of malignancies which pose challenges in understanding their epidemiology, pathobiology, treatment responses and long-term outcomes. Evolving diagnostic classification and fast-paced therapy development compound these challenges. Robust real-world data (RWD) collection and analysis using clinical registries …

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Distress screening and management for adolescents and young adults: 2022 NCI community oncology program landscape assessment

Karly M. Ingram, Lingyun Ji, Han-Wei V. Wu, Kristin Bingen et autres

PURPOSE: Adolescent and young adult cancer patients (AYAs, aged 15-39) are at an elevated risk of experiencing psychosocial distress. Furthermore, most AYAs receive care in community oncology settings where little is known about distress screening and management for AYAs. We examined distress …

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Adolescents and Young Adults With Acute Lymphoblastic Leukemia: Qualitative Barriers and Facilitators to Guideline-Concordant Care

Allison Grimes, Julie A. Wolfson, C Kerber, Kristin Bingen et autres

Introduction Progress in acute lymphoblastic leukemia (ALL) affecting adolescents and young adults (AYAs), aged 15-39 years, has been challenged by aggressive disease biology, low clinical trial participation, unique supportive care needs, and heterogeneity across treatment settings with lack of age-based standardized therapy. …

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Beyond the Hospital: Understanding Psychosocial Support Uptake for Adolescents and Young Adults With Cancer in Community-Based and Nonprofit Programs

Christabel K. Cheung, Nishtha Gupta, H Lee, SK Parsons et autres

IntroductionAdolescents and young adults (AYAs) with cancer experience substantial psychosocial distress, yet participation in supportive oncology services remains low. Community-based and nonprofit programs outside hospital systems provide essential developmentally appropriate supportive care, particularly during transitions to surveillance and longer-term follow-up, yet determinants …

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Defining Practice Capacity for Cancer Care Delivery to Adolescents and Young Adults in the Community Setting: 2022 Landscape Assessment Results

Lingyun Ji, Melissa P. Beauchemin, Sheila J. Santacroce, SK Parsons et autres

Background: Adolescents and young adults (AYAs) commonly receive cancer care in the community setting, but the availability of treatment options, resources, and support services for this population is not well known. The National Cancer Institute Community Oncology Research Program (NCORP) funds a …

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Availability of cancer survivorship services for adolescents and young adults: Findings from the 2022 NCI Community Oncology Research Program Landscape Assessment

Erin M. Mobley, Lingyun Ji, Alexandra M. Psihogios, Karly M. Ingram et autres

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Subsequent Neoplasm Risk After Modern Mediastinal Radiation Therapy for Pediatric Hodgkin Lymphoma: Insights From a Multi-Institutional Children’s Oncology Group Trial

Sarah A. Milgrom, Harald Paganetti, Hitesh Dama, Lindsay Renfro et autres

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Three-Year Follow-Up of Nivolumab-AVD Versus Brentuximab Vedotin–AVD in Adolescents With Advanced-Stage Classic Hodgkin Lymphoma on S1826

Sharon M. Castellino, H. Li, Alex F. Herrera, Michael LeBlanc et autres

We present a subset analysis on the adolescent cohort of the S1826 randomized phase three trial, comparing nivolumab, doxorubicin, vinblastine, dacarbazine (N-AVD) to brentuximab vedotin-AVD (BV-AVD) in newly diagnosed advanced-stage (AS, stages III and IV) classic Hodgkin lymphoma (cHL). Among 994 patients …

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35 | SECOND MALIGNANT NEOPLASM RISK AFTER MEDIASTINAL RADIOTHERAPY FOR PEDIATRIC HODGKIN LYMPHOMA ON CHILDREN’S ONCOLOGY GROUP AHOD1331

Sarah A. Milgrom, Harald Paganetti, Hitesh Dama, Lindsay A. Renfro et autres

Introduction: Despite excellent survival outcomes, significant chronic health conditions occur among pediatric, adolescent, and young adult classical Hodgkin lymphoma (cHL) survivors as a result of current chemotherapy and radiation regimens.Targeting both the tumor microenvironment as well as tumorspecific antigens have been proven …

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1647P Clinical validity of plasma DNA testing to identify BRCA-mutated (BRCA+) patients in the MAGNITUDE study

G. Attard, Umesh Singh, Yunhua Xu, Leonie Farrington et autres

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