Ali A. Zarban

Phosphatidylinositol‐4,5‐bisphosphate 3‐kinase ( PI3K) inhibitors reduce vascular inflammation in vitro and in vivo

Hiba Chaudhry, Ali A. Zarban, Silvia Cellone Trevelin, Xenia Kodji et autres

BACKGROUND AND PURPOSE: Endothelial cells play central roles in increasing vascular permeability and leukocyte recruitment. Therapeutic approaches for treating endothelial cell barrier dysfunction to reduce unwanted fluid accumulation in tissues are limited. Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) enzymes are implicated in signalling inflammatory endothelial …

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Barbeya Oleoides Leaves Extract Mitigates Acetaminophen- Induced Nephrotoxicity by Reducing Oxidative Stress and Inflammation in a Rat Model

Abdulmajeed M. Jali, Mohammad Firoz Alam, Sulaiman Sayyar, Faroq Kamli et autres

Acetaminophen is widely used as an analgesic and antipyretic, but its potential for nephrotoxicity, particularly in overdose situations, remains a significant concern. Identifying agents that can mitigate this nephrotoxicity is crucial for kidney protection. Barbeya oleoides Schweinfurth (BOL), known for its antioxidant …

TNIK: A redox sensor in endothelial cell permeability

Justin Joachim, Davide Maselli, Emmanouela Petsolari, Jurjan Aman et autres

Dysregulation of endothelial barrier integrity can lead to vascular leak and potentially fatal oedema. TNF-α controls endothelial permeability during inflammation and requires the actin organizing Ezrin-Radixin-Moesin (ERM) proteins. We identified TRAF2 and NCK-interacting kinase (TNIK) as a kinase directly phosphorylating and activating …

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Elucidating the potential of CGRP as an inflammatory mediator in skin vasculature and cardiovascular disease

Ali A. Zarban

Elucidating the Ability of CGRP to Modulate Microvascular Events in Mouse Skin

Ali A. Zarban, Hiba Chaudhry, João de Sousa Valente, Fulye Argunhan et autres

Oedema formation and polymorphonuclear leukocyte (neutrophil) accumulation are involved in both acute and chronic inflammation. Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide that is released from stimulated sensory nerves. CGRP is a potent vasodilator neuropeptide, especially when administered to the cutaneous …

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Enhancing Techniques for Determining Inflammatory Edema Formation and Neutrophil Accumulation in Murine Skin

Ali A. Zarban, Hiba Chaudhry, Davide Maselli, Xenia Kodji et autres

Inflammatory edema formation and polymorphonuclear leukocyte (neutrophil) accumulation are common components of cutaneous vascular inflammation, and their assessment is a powerful investigative and drug development tool but typically requires independent cohorts of animals to assess each. We have established the use of …

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The role of an alpha-selective phosphoinositide-3 kinase inhibitor in vascular inflammation

Hibba Chaudhry, Ali A. Zarban, Xenia Kodji, Camilla Cerutti et autres

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main funding source(s): British Heart Foundation Introduction Cardiovascular inflammation is associated with endothelial cell (EC) damage, resulting in leukocyte trafficking and oedema formation. Inflammation disrupts EC junctions, increasing microvascular permeability, and resulting in …

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(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5

João de Sousa Valente, Khadija M. Alawi, Sabah Bharde, Ali A. Zarban et autres

has been identified as a TRPC4/5 agonist. Here, we studied whether or not EA has any anti-inflammatory and analgesic properties via TRPC4/5 in the carrageenan model of inflammation. We found that EA treatment in CD1 mice inhibited thermal hyperalgesia and mechanical allodynia …

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Vascular Endothelial Primary Cilia: Mechanosensation and Hypertension

Ashraf M. Mohieldin, Hossain Saad Md Zubayer, Alzahra J. Al Omran, Hannah C. Saternos et autres

Primary cilia are sensory organelles that extend from the cell surface and sense extracellular signals. Endothelial primary cilia protruding from the inner surface of blood vessel walls sense changes in blood flow and convert this mechanosensation into an intracellular biochemical/molecular signal, which …

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Localization and Distribution of Primary Cilia in the Adult Mouse Heart

Ali A. Zarban, Hannah C. Saternos, Andrea L. Nestor‐Kalinoski, Lijun Liu et autres

Although primary cilia have been shown to play crucial roles in the development of embryonic mouse heart, their presence and function in adult mouse heart remains controversial. In this study, the presence of primary cilia in adult mouse heart was investigated. The …