Andrea L. Nestor‐Kalinoski

Intestinal Serotonergic Vagal Signaling as a Mediator of Microbiota-Induced Hypertension

Alan de Araujo, Hemaa Sree Kumar, Tao Yang, Emily otmanowski et autres

BACKGROUND: Hypertension is a pervasive global health challenge, impacting more than 1 billion individuals worldwide. Despite strides in therapeutic strategies, a significant proportion of patients remain resistant to the currently available therapies. Although conventional treatments predominantly focus on cardiac, renal, and cerebral …

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Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways

Shafiya Imtiaz Rafiqi, Ahmad Aldasouqi, Rodis Paparodis, Sandesh Dewan et autres

Background: The generation of functionally active, stable T regulatory cells (Tregs) is a crucial target of type 1 diabetes (T1D) immunotherapy. This study investigated therapeutic intervention for T1D/Latent autoimmune diabetes in adults (LADA), wherein the diabetogenic proinflammatory Treg (intermediate) cell subset was …

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A window into intracellular events in myositis through subcellular proteomics

Jennifer M. Peterson, Valérie Leclair, Olumide E. Oyebode, Dema M. Herzallah et autres

OBJECTIVE AND DESIGN: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of inflammatory muscle disorders of unknown etiology. It is postulated that mitochondrial dysfunction and protein aggregation in skeletal muscle contribute to myofiber degeneration. However, molecular pathways that lead to protein aggregation …

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The Large GTPase Guanylate-Binding Protein-1 (GBP-1) Promotes Mitochondrial Fission in Glioblastoma

Ryan C. Kalb, Geoffrey O. Nyabuto, Michael P. Morran, Swagata Maity et autres

Glioblastomas (aka Glioblastoma multiformes (GBMs)) are the most deadly of the adult brain tumors. Even with aggressive treatment, the prognosis is extremely poor. The large GTPase Guanylate-Binding Protein-1 (GBP-1) contributes to the poor prognosis of GBM by promoting migration and invasion. GBP-1 …

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Gut microbiota-derived Metabolite, Shikimic Acid, inhibits vascular smooth muscle cell proliferation and migration

Sanjana Kumariya, Arturo Grano de Oro, Andrea L. Nestor‐Kalinoski, Bina Joe et autres

Gut microbiota dysbiosis is linked to vascular wall disease, but the mechanisms by which gut microbiota cross-talk with the host vascular cells remain largely unknown. Shikimic acid (SA) is a biochemical intermediate synthesized in plants and microorganisms, but not mammals. Surprisingly, recent …

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A window into intracellular events in myositis through subcellular proteomics

Jennifer M. Peterson, Valérie Leclair, Olumide E. Oyebode, Dema M. Herzallah et autres

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Spatial organization of putrescine synthesis in plants

Kumud Joshi, Sheaza Ahmed, Lingxiao Ge, Arefeh Avestakh et autres

Three plant pathways for the synthesis of putrescine have been described to date. These are the synthesis of putrescine from ornithine, by ornithine decarboxylase (ODC); the synthesis of putrescine from arginine by arginine decarboxylase, agmatine iminohydrolase (AIH) and N-carbamoylputrescine amidohydrolase (NLP1); and …

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The large GTPase Guanylate-Binding Protein-1 (GBP-1) promotes mitochondrial fission in glioblastoma

Ryan C. Kalb, Geoffrey O. Nyabuto, Michael P. Morran, Swagata Maity et autres

Abstract Glioblastomas (aka Glioblastoma multiforme (GBMs)) are the most deadly of the adult brain tumors. Even with aggressive treatment, the prognosis is extremely poor. The large GTPase Guanylate-Binding Protein-1 (GBP-1) contributes to the poor prognosis of GBM by promoting migration and invasion. …

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Smart exosomes enhance PDAC targeted therapy

Justin F. Creeden, Jonathan Sevier, Jian‐Ting Zhang, Yakov Lapitsky et autres

Exosomes continue to attract interest as a promising nanocarrier drug delivery technology. They are naturally derived nanoscale extracellular vesicles with innate properties well suited to shuttle proteins, lipids, and nucleic acids between cells. Nonetheless, their clinical utility is currently limited by several …

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Gut Microbiota-Derived Metabolite, Shikimic Acid, Inhibits Vascular Smooth Muscle Proliferation Via the Activation of Ampk Signaling

Sanjana Kumariya, Arturo Grano de Oro, Andrea L. Nestor‐Kalinoski, Bina Joe et autres

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Spatial Organization of Putrescine Synthesis in Plants

kumud Joshi, Sheaza Ahmed, Lingxiao Ge, Arefeh Avestakh et autres

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Atbat1 is a Proton-Mediated Transporter of Arginine, Gaba and Polyamines

Menaka Ariyaratne, Lingxiao Ge, kumud Joshi, Arefeh Avestakh et autres

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