Anshoo Choudhary

Analysis of the BOLD signal along colour-opponent pathways in LGN and V1 and microstructural alterations of the optic radiation in POAG and OHT patients

Joanne Powell, Laura M. Parkes, Anshoo Choudhary, Sophie M. Wuerger

PURPOSE: Primary open angle glaucoma (POAG) is associated with retinal ganglion cell loss and atrophies in the lateral geniculate nucleus (LGN) and visual cortex (V1). The causes and pathogenesis of glaucoma are unclear; with increased risk of progression to glaucoma in patients …

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Massively parallel sequencing of mitochondrial genome in primary open angle glaucoma identifies somatically acquired mitochondrial mutations in ocular tissue

Neeru Amrita Vallabh, Brian Lane, David A. C. Simpson, Marc Fuchs et autres

Glaucoma is a sight threatening neurodegenerative condition of the optic nerve head associated with ageing and marked by the loss of retinal ganglion cells. Mitochondrial dysfunction plays a crucial role in the pathogenesis of neurodegeneration in the most prevalent type of glaucoma: …

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Long-term outcomes of phacoemulsification with iStent inject® implantation in narrow angle glaucoma

Zhihang Cheng, Tasmin Berman, Anshoo Choudhary

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Visualization of Scleral Flap Patency in Glaucoma Filtering Blebs Using OCT

Jeremy C. K. Tan, Matthew Roney, Anshoo Choudhary, Mark Batterbury et autres

Purpose: To investigate the use of anterior-segment OCT (AS-OCT) to visualize the aqueous outflow pathway and patency of the scleral flap in glaucoma filtration surgery blebs. Design: Cross-sectional study. Subjects: Two hundred five filtering blebs of 112 patients with glaucoma who had …

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Swept-Source Anterior Segment Optical Coherence Tomography Imaging and Quantification of Bleb Parameters in Glaucoma Filtration Surgery

Jeremy C. K. Tan, Hussameddin Muntasser, Anshoo Choudhary, Mark Batterbury et autres

This paper describes a technique for using swept-source anterior segment optical coherence tomography (AS-OCT) to visualize internal bleb microstructure and objectively quantify dimensions of the scleral flap and trabeculo-Descemet window (TDW) in non-penetrating glaucoma filtration surgery (GFS). This was a cross-sectional study …

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Low-Dose Propofol with Peribulbar Anaesthesia for Cataract Surgery

Mahmoud Ahmed, Yamini Krishna, Petya Popova, Rose Herbert et autres

In this paper, we investigate the effect of sedation using low-dose propofol on patient reported outcome measures (PROMS) in patients undergoing cataract surgery. This is a randomised, single-blinded observational prospective study. Patients undergoing elective cataract surgery using peribulbar anaesthesia over consecutive cataract …

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Evidence of impaired mitochondrial cellular bioenergetics in ocular fibroblasts derived from glaucoma patients

Neeru Amrita Vallabh, Jane A. Armstrong, Gabriela Czanner, Brian McDonagh et autres

Glaucoma is a progressive optic neuropathy characterized by the neurodegeneration of the retinal ganglion cells (RGCs) resulting in irreversible visual impairment and eventual blindness. RGCs are extremely susceptible to mitochondrial compromise due to their marked bioenergetic requirements and morphology. There is increasing …

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Long-term outcomes of viscocanalostomy and phaco-viscocanalostomy in patients with narrow angle glaucoma

Tasmin Berman, Tobi Somerville, Anshoo Choudhary

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Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)

Jason Bacharach, Andrew J. Tatham, Gloria E. Ferguson, Sandra Belalcázar et autres

OBJECTIVE: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). METHODS: This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG …

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Deep sclerectomy and trabeculectomy augmented with Mitomycin C: 2-year post-operative outcomes

Rahul Dwivedi, Tobi Somerville, Robert Cheeseman, Clare E. Rogers et autres

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Thrombospondin-2 is up-regulated by TGFβ2 and increases fibronectin expression in human trabecular meshwork cells

Stephnie M. Kennedy, Carl Sheridan, Victoria Kearns, Emine Kubra Bilir et autres

Elevated intraocular pressure (IOP) is a major risk factor for the development of primary open-angle glaucoma (POAG). This is from an increased aqueous humour (AH) outflow resistance through the trabecular meshwork (TM). The pathogenic mechanisms leading to the increase in TM outflow …

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Evidence of somatic mitochondrial DNA mutations in primary open angle glaucoma

Neeru Amrita Vallabh, Brian Lane, David A. C. Simpson, Marc Fuchs et autres

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