Victoria Kearns

Regional variations in the biomechanical properties of the isolated porcine retina: potential implications for subretinal injection

Dario L’Abbate, Kia Prescott, Ahmed Abass, Brendan Geraghty et autres

PURPOSE: To determine how the biomechanical properties of the retina vary across different quadrants of the eye and how commonly used storage media affect retinal biomechanics. METHODS: A total of 130 retinal strips were dissected from 90 six-month-old pigs eyes for uniaxial …

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Transforming growth factor beta-2 drives trabecular meshwork progenitor cell differentiation through SMAD2/3 signaling

Xiaochen Fan, Emine Kubra Bilir, Olivia A. Kingston, Victoria Kearns et autres

Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness, yet its underly mechanisms remain unclear. Elevated intraocular pressure (IOP), the only modifiable risk factor for POAG, arises from increased resistance to aqueous humor outflow within the conventional outflow pathway, which …

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Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applications

Nimeet Desai, Helen Elizabeth Colley, Yamini Krishna, Lucy A. Bosworth et autres

Delivering drugs effectively to the ocular surface is challenging due to rapid clearance mechanisms, including blinking, tear turnover, and protective barriers of the conjunctival and corneal epithelium. As a result, conventional options such as eye drops often fail to provide sustained therapeutic …

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Author response for "Passive Nanorheological Tool to Characterise Hydrogels"

Moira Lorenzo-Lopez, Victoria Kearns, Eann A. Patterson, Judith M. Curran

Transcriptome Profiling of Trabecular Meshwork Progenitor Cells

Xiaochen Fan, Emine Kubra Bilir, Brian Lane, Olivia A. Kingston et autres

The loss and dysfunction of trabecular meshwork (TM) cells are implicated in aging and primary open-angle glaucoma. TM progenitor cells (TMPCs) contribute to the population and function of the TM, but their identity is not well elucidated. This study aimed to identify …

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Passive nanorheological tool to characterise hydrogels

Moira Lorenzo Lopez, Victoria Kearns, Eann A. Patterson, Judith M. Curran

Hydrogels are highly versatile, multi-phase materials with a wide variety of applications, due to their complex structures and tuneable features at the micron and sub-micron scale. Physical and chemical properties within the local environments contribute to the overall properties of a hydrogel. …

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Correction: Passive nanorheological tool to characterise hydrogels

Moira Lorenzo Lopez, Victoria Kearns, Eann A. Patterson, Judith M. Curran

Correction for ‘Passive nanorheological tool to characterise hydrogels’ by Moira Lorenzo Lopez et al. , Nanoscale , 2025, https://doi.org/10.1039/d5nr00875a.

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Diffusion of nanoparticles in heterogeneous hydrogels as vitreous humour in vitro substitutes

Moira Lorenzo Lopez, Victoria Kearns, Judith M. Curran, Eann A. Patterson

Nanomedicine has the potential to increase the biostability of drugs to treat retinal diseases, improving their performance and decreasing the required number of intravitreal injections. However, accurate pharmacokinetic studies of these nanoparticle-drug conjugates, nanoparticle motion across the vitreous humour and interaction with …

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Biomechanical considerations for optimising subretinal injections

Dario L’Abbate, Kia Prescott, Brendan Geraghty, Victoria Kearns et autres

Subretinal injection is the preferred delivery technique for various novel ocular therapies and is widely used because of its precision and efficient delivery of gene and cell therapies; however, choosing an injection point and defining delivery parameters to target a specified retinal …

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Sustained-release drug delivery systems

Rachel Williams, Helen Cauldbeck, Victoria Kearns

The design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to the eye could overcome the limitations of topically administered eye drops. Understanding how to modify or design new materials with specific functional properties …

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Diffusion of Nanoparticles in Heterogeneous Hydrogels as Vitreous Humour Substitutes

Moira Lorenzo Lopez, Victoria Kearns, Eann A. Patterson, Judith M. Curran

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P-02 The effect of varying storage conditions on the mechanical properties of porcine retina

Kia Prescott, Dario L’Abbate, Brendan Geraghty, DAVID H. STEEL et autres

Introduction Accurate characterisation of the physical properties of the retina is essential for understanding the effects of age, disease mechanisms and developing effective surgical interventions. Ex vivo measurements have been used to do this, however the effect of storage conditions on the …

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