Accès ouvert
2026
article
OpenAlex
João Eduardo Izaías, Bruna E. Ono, Artur O. Sales, Thais S. Rodrigues et autres
Long-term breast cancer (BC) survivors previously treated with doxorubicin- and trastuzumab-based chemotherapy show reduced muscle metaboreflex activation, which partly explains attenuated pressor and sympathetic neural responses to exercise in this population. Importantly, these findings shed light on the blunted exercise-induced blood pressure …
br, us
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Accès ouvert
2026
article
OpenAlex
João Eduardo Izaías, Artur O. Sales, Bruna E. Ono, Thais S. Rodrigues et autres
BACKGROUND: Long-term survivors of breast cancer (BC) treated with doxorubicin and trastuzumab-based chemotherapy are at increased risk of developing cardiovascular disease. However, the physiological mechanisms associated with increased cardiovascular disease risk are completely unknown. We hypothesized that long-term survivors of BC, compared …
br, us
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Accès ouvert
2025
article
OpenAlex
Samuel T. Ruzzene, Auburn R. Berry, Vinícius P. Garcia, Whitney B. Valenti et autres
Obesity is associated with profound impairment in the capacity of the vascular endothelium to release tissue-type plasminogen activator (t-PA), the primary mechanism underlying endogenous thrombolysis. Circulating endothelial cell-derived extracellular vesicles (EMVs) have been linked to endothelial dysfunction. This study demonstrates that circulating …
us
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Accès ouvert
2025
article
OpenAlex
Auburn R. Berry, Samuel T. Ruzzene, Emily I. Ostrander, Kendra N. Wegerson et autres
Erythritol, a common non-nutritive sweetener, is associated with increased risk of cardiovascular and cerebrovascular events. This study provides novel data, demonstrating that erythritol (at a concentration typically contained in a standard-size commercially available artificially sweetened beverage) adversely affects brain microvascular endothelial cell …
us, fr
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Accès ouvert
2025
article
OpenAlex
Bruna E. Ono, João Eduardo Izaías, Artur O. Sales, J Niec et autres
Patients with long COVID, even 2 yr after SARS-CoV-2 infection, exhibited sympathetic neural overdrive, aortic stiffening, endothelial dysfunction, cardiac morphofunctional changes, diminished aerobic exercise capacity, increased circulating endothelial cell-derived EVs, decreased antioxidant activity, and increased oxidant activity. Moreover, we showed that the …
br, be, us
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2025
article
OpenAlex
Auburn Berry, Samuel T. Ruzzene, João Eduardo Izaías, Jared J. Greiner et autres
Adults with obesity demonstrate accelerated rates of atherosclerosis, as well as increased incidence of myocardial infarction and stroke. As such, obesity reduces the number of years lived free of cardiovascular disease (CVD) and increases the number of years lived with CVD, contributing …
us
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2025
article
OpenAlex
Auburn Berry, Samuel T. Ruzzene, João Eduardo Izaías, Joshua Holzer et autres
Erythritol is a widely used non-nutritive sweetener that has been purported to be a safe alternative to sugar due to its minimal impact on blood glucose and insulin levels. However, recent evidence has linked erythritol to increased risk of cardiovascular and cerebrovascular …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Auburn Berry, Samuel T. Ruzzene, João Eduardo Izaías, Joshua Holzer et autres
Factors that initiate, promote and accelerate obesity-related vascular dysfunction and disease are not completely understood. With increased adiposity there is an apparent pathologic shift in the phenotype of adipose tissue and its secretome. Indeed, interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Samuel T. Ruzzene, Vinícius P. Garcia, João Eduardo Izaías, Hannah K. Fandl et autres
The prevalence of overweight/obesity continues to increase in the United States. With increased adiposity there is a shift in the phenotype and biology of adipose tissue resulting in an adipocyte secretome with proatherogenic consequences. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has …
us
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2023
conference-abstract
OpenAlex
João Eduardo Izaías, Renata Bernardes, Bruna E. Ono, Diego Faria et autres
Introduction: Previous evidence demonstrates that breast cancer (BC) survivors who were treated with doxorubicin and trastuzumab-based chemotherapy have an increased risk of developing cardiovascular (CV) disease at least 7 years after completion of cancer treatment. The reasons for the increased CV disease …
br, us
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Accès ouvert
2023
article
OpenAlex
Diego Faria, Renata Junqueira Moll-Bernardes, Laura Testa, Camila Motta Venchiarutti Moniz et autres
Previous studies show that COVID-19 survivors have elevated muscle sympathetic nerve activity (MSNA), endothelial dysfunction, and aortic stiffening. However, the neurovascular responses to mental stress and exercise are still unexplored. We hypothesized that COVID-19 survivors, compared with age- and body mass index …
br, us
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Accès ouvert
2022
article
OpenAlex
Diego Faria, Renata Junqueira Moll-Bernardes, Laura Testa, Camila Motta Venchiarutti Moniz et autres
BACKGROUND: COVID-19 has become a dramatic health problem during this century. In addition to high mortality rate, COVID-19 survivors are at increased risk for cardiovascular diseases 1-year after infection. Explanations for these manifestations are still unclear but can involve a constellation of …
br, us
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