Neurovascular and hemodynamic responses to mental stress and exercise in severe COVID-19 survivors
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Le résumé fourni par la source
Previous studies show that COVID-19 survivors have elevated muscle sympathetic nerve activity (MSNA), endothelial dysfunction, and aortic stiffening. However, the neurovascular responses to mental stress and exercise are still unexplored. We hypothesized that COVID-19 survivors, compared with age- and body mass index (BMI)-matched control subjects, exhibit abnormal neurovascular responses to mental stress and physical exercise. Fifteen severe COVID-19 survivors (aged: 49 ± 2 yr, BMI: 30 ± 1 kg/m2) and 15 well-matched control subjects (aged: 46 ± 3 yr, BMI: 29 ± 1 kg/m2) were studied. MSNA (microneurography), forearm blood flow (FBF), and forearm vascular conductance (FVC, venous occlusion plethysmography), mean arterial pressure (MAP, Finometer), and heart rate (HR, ECG) were measured during a 3-min mental stress (Stroop Color-Word Test) and during a 3-min isometric handgrip exercise (30% of maximal voluntary contraction). During mental stress, MSNA (frequency and incidence) responses were higher in COVID-19 survivors than in controls ( P < 0.001), and FBF and FVC responses were attenuated ( P < 0.05). MAP was similar between the groups ( P > 0.05). In contrast, the MSNA (frequency and incidence) and FBF and FVC responses to handgrip exercise were similar between the groups ( P > 0.05). MAP was lower in COVID-19 survivors ( P < 0.05). COVID-19 survivors exhibit an exaggerated MSNA and blunted vasodilatory response to mental challenge compared with healthy adults. However, the neurovascular response to handgrip exercise is preserved in COVID-19 survivors. Overall, the abnormal neurovascular control in response to mental stress suggests that COVID-19 survivors may have an increased risk to cardiovascular events during mental challenge.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neurovascular and hemodynamic responses to mental stress and exercise in severe COVID-19 survivors
- Date Crossref
- 01/09/2023
- Éditeur
- American Physiological Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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D’Or Institute for Research and Education pays non établi dans la noticeOrganisation à but non lucratif
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Instituto do Coração pays non établi dans la noticeÉtablissement de santé
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Universidade Federal de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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University of Colorado Boulder Department of Integrative Physiology pays non établi dans la noticeUniversité ou école supérieure
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Universidade de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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Federal University of São Paulo Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
D’Or Institute for Research and Education, Instituto do Coração — Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo et Universidade Federal de São Paulo, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.