Sarah C. Charnaud

Towards a shared vision for research on evidence-informed policy-making

Bastien Kolt, Tanja Kuchenmüller, Ahmed Mandil, Annette Boaz et autres

The World Health Organization (WHO) defines knowledge translation as the exchange, synthesis and effective com- munication of reliable and relevant research results.(1) Also known as research utilization or knowledge mobilization, knowledge translation is a transdisciplinary process that promotes sustained interaction between researchers …

ch, Égypte, gb, co, sg (code pays fourni par la source)

Global research funding for traditional, complementary and integrative medicine

Amie Steel, Kirsten Baker, Jon Adams, Hope Foley et autres

Objective: To explore the global research funding landscape for traditional, complementary and integrative medicine. Methods: We conducted a three-part study to assess the global research funding landscape. First, we searched the Dimensions database and online sources using Microsoft Copilot and Google between …

au, ch, us, in, ph, Égypte, dk, br, pk (code pays fourni par la source)

Efficacy of low-dose primaquine plus artemether-lumefantrine or dihydroartemisinin-piperaquine for radical cure of Plasmodium vivax in the Solomon Islands: a randomised clinical trial

Rob S. James, Thomas Obadia, Lyndes Wini, Albino Bobogare et autres

Background Primaquine (PQ) remains the only 8-aminoquinoline endorsed by the WHO for treatment of latent Plasmodium vivax liver-stage parasites. PQ is a prodrug, with metabolism and therapeutic activity influenced by inherent human CYP2D6 polymorphisms and by poorly understood interactions with variably co-administered …

au, fr, ua, sb, id, gb (code pays fourni par la source)

The WHO global landscape of cancer clinical trials

Raffaella Casolino, Lambed Tatah, Sarah C. Charnaud, Marilina Santero et autres

ch (code pays fourni par la source)

WHO global research agenda for hand hygiene improvement in health care: a Delphi consensus study

Benedetta Allegranzi, Ermira Tartari, Claire Kilpatrick, Julie Storr et autres

OBJECTIVE: To identify global research priorities for improving hand hygiene in healthcare settings and develop a 2023-2030 research agenda to guide funding, coordinate research, promote investment, and inform policy for enhanced healthcare quality and safety. DESIGN: Expert consensus study using a modified …

pk, ch, mt, sa, pt, il (code pays fourni par la source)

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum

Thorey K. Jonsdottir, Brendan Elsworth, Simon A. Cobbold, Mikha Gabriela et autres

A key element of Plasmodium biology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel-forming protein complex termed the …

au (code pays fourni par la source)

WHO target product profiles to shape global research and development

Sarah C. Charnaud, Vasee Moorthy, John C. Reeder, Anna Laura Ross

Research and development leading to new and improved health products is essential for achieving healthier lives for populations worldwide. However, new products in development do not always match the global need for products for neglected diseases and populations. To promote research, provide …

ch (code pays fourni par la source)

Malaria in pregnancy (MiP) studies assessing the clinical performance of highly sensitive rapid diagnostic tests (HS-RDT) for Plasmodium falciparum detection

Xavier C. Ding, Sandra Incardona, Elisa Serra‐Casas, Sarah C. Charnaud et autres

BACKGROUND: Rapid diagnostic tests (RDTs) are effective tools to diagnose and inform the treatment of malaria in adults and children. The recent development of a highly sensitive rapid diagnostic test (HS-RDT) for Plasmodium falciparum has prompted questions over whether it could improve …

ch, gb, us, Kenya (code pays fourni par la source)

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum

Thorey K. Jonsdottir, Brendan Elsworth, Simon A. Cobbold, Mikha Gabriela et autres

Abstract A key element of Plasmodium biology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel-containing protein complex termed …

au (code pays fourni par la source)

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture

Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir et autres

Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in parasite invasion and proliferation are therefore intrinsically of great …

au, se, gb, ch, us (code pays fourni par la source)

PacBio long-read amplicon sequencing enables scalable high-resolution population allele typing of the complex CYP2D6 locus

Sarah C. Charnaud, Jacob E. Munro, Lucie Semenec, Ramin Mazhari et autres

The CYP2D6 enzyme is estimated to metabolize 25% of commonly used pharmaceuticals and is of intense pharmacogenetic interest due to the polymorphic nature of the CYP2D6 gene. Accurate allele typing of CYP2D6 has proved challenging due to frequent copy number variants (CNVs) …

au (code pays fourni par la source)

Transcriptome and histone epigenome of Plasmodium vivax salivary-gland sporozoites point to tight regulatory control and mechanisms for liver-stage differentiation in relapsing malaria

Ivo Müller, Aaron R. Jex, Stefan H. I. Kappe, Sebastian A. Mikolajczak et autres

fr, au, us, th, de (code pays fourni par la source)