Hayley E. Bullen

Plasmodium berghei is resistant to aryl amino acetamides that inhibit P. falciparum growth by targeting the phospholipid transfer protein Pf START1.

Claudia BG Barnes, Mrittika Chowdury, Dawson B. Ling, Thomas McClean et autres

In a previous screen for compounds that inhibit Plasmodium falciparum merozoite invasion of red blood cells, we identified the Medicines for Malaria Venture compound MMV006833. This compound inhibits Pf START1, a protein implicated in the expansion of the nascent parasitophorous vacuole membrane …

au (code pays fourni par la source)

Improving the capacity of vaccine-induced antibodies to arrest the growth of Plasmodium falciparum

Paul R. Gilson, Alysha H. Literski, Claudia B. G. Barnes, Molly Parkyn Schneider et autres

au, gb (code pays fourni par la source)

Unpacking boxes: identification of novel inhibitors of malaria parasite invasion

Claudia B. G. Barnes, Molly Parkyn Schneider, Olivia D. Ventura, Zahra Razook et autres

With resistance to current frontline antimalarial treatments rapidly emerging in malaria endemic regions, there is an urgent need to identify new antimalarial compounds with novel mechanisms of action. Currently, no clinically used antimalarials target erythrocyte invasion, the process by which the short-lived, …

au (code pays fourni par la source)

MMV687794 blocks Plasmodium falciparum invasion of red blood cells by targeting a Surface-associated Lipid-Interacting Rhoptry Protein, Pf SLIRP

Dawson B. Ling, Ghizal Siddiqui, Christopher A. MacRaild, Yoshiki Yamaryo‐Botté et autres

Abstract Invasion of red blood cells (RBCs) by the human malaria parasite, Plasmodium falciparum , drives disease. During invasion, the parasite pushes its way into the RBC while wrapping the RBC membrane around itself to establish the parasitophorous vacuole, a stable niche …

au, fr (code pays fourni par la source)

A Pyridyl-Furan Series Developed from the Open Global Health Library Block Red Blood Cell Invasion and Protein Trafficking in Plasmodium falciparum through Potential Inhibition of the Parasite’s PI4KIIIB Enzyme

Dawson B. Ling, William Nguyen, Oliver Looker, Zahra Razook et autres

High Resolution Image Download MS PowerPoint Slide With the resistance increasing to current antimalarial medicines, there is an urgent need to discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of …

au, ch, gb (code pays fourni par la source)

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum

Thorey K. Jonsdottir, Brendan Elsworth, Simon A. Cobbold, Mikha Gabriela et autres

A key element of Plasmodium biology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel-forming protein complex termed the …

au (code pays fourni par la source)

Protein disulfide isomerases – a way to tackle malaria

Fiona Angrisano, A. D. Ford, Andrew M. Blagborough, Hayley E. Bullen

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhibition could be …

au, gb (code pays fourni par la source)

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasite’s PI4KIIIb enzyme

Dawson B. Ling, William Nguyen, Oliver Looker, Zahra Razook et autres

ABSTRACT With resistance increasing to current antimalarial medicines, there is an urgent need to discover new drug targets and to develop new medicines against these targets. We therefore screened the Open Global Health Library of Merck KGaA, Darmstadt, Germany of 250 compounds …

au, ch (code pays fourni par la source)

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum

Thorey K. Jonsdottir, Brendan Elsworth, Simon A. Cobbold, Mikha Gabriela et autres

Abstract A key element of Plasmodium biology and pathogenesis is the trafficking of ~10% of the parasite proteome into the host red blood cell (RBC) it infects. To cross the parasite-encasing parasitophorous vacuole membrane, exported proteins utilise a channel-containing protein complex termed …

au (code pays fourni par la source)

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

Oliver Looker, Madeline G. Dans, Hayley E. Bullen, Brad E. Sleebs et autres

Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatly assist parasite survival. As resistance to all …

au (code pays fourni par la source)

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

Oliver Looker, Madeline G. Dans, Hayley E. Bullen, Brad E. Sleebs et autres

Abstract Plasmodium falciparum parasites which cause malaria, traffic hundreds of proteins into the red blood cells (RBCs) they infect. These exported proteins remodel their RBCs enabling host immune evasion through processes such as cytoadherence that greatly assist parasite survival. As resistance to …

au (code pays fourni par la source)

The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture

Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir et autres

Infection with Plasmodium falciparum parasites results in approximately 627,000 deaths from malaria annually. Key to the parasite's success is their ability to invade and subsequently grow within human erythrocytes. Parasite proteins involved in parasite invasion and proliferation are therefore intrinsically of great …

au, se, gb, ch, us (code pays fourni par la source)