A Vasilescu

Predictors of In-Hospital Mortality Among Hospitalized Colistin-Treated Patients at a Tertiary Urology–Nephrology Referral Center

Viorel Dragoş Radu, Ana-Maria Raluca Pauna, Rodica Radu, Liliana Mititelu-Tarțău et autres

Background/Objectives: Colistin is a last-resort agent against multidrug-resistant Gram-negative infections and is administered predominantly to complex, comorbid inpatients in whom mortality is high. We aimed to identify independent baseline predictors of in-hospital mortality in colistin-treated patients and to characterize temporal changes in …

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Beyond Carrier Design: Fabrication Method as the Hidden Driver of NSAID Nanomedicine Performance

Ana-Maria Raluca Pauna, Liliana Mititelu-Tarțău, Angy Abu Koush, Roxana-Ionela Vasluianu et autres

Background/Objectives: Diclofenac (DCF) and other nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation management; however, their clinical significance is limited by poor aqueous solubility, short biological half-life, and dose-dependent gastrointestinal, renal, and cardiovascular adverse effects. Nanocarrier-based delivery systems have …

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Liver Xenotransplantation: From Early Primate Trials to the First-in-Human Porcine Bridging Therapies

Alexandru Năstase, A Vasilescu, Ana Maria Trofin, Nicolae Florin Iftimie et autres

Liver transplantation remains the definitive treatment for end-stage liver disease and acute liver failure, yet a critical and persistent shortage of donor organs results in thousands of preventable deaths annually worldwide. Xenotransplantation has emerged as a potential solution to this structural deficit. …

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The Importance of Gastropexy in Minimally Invasive Hiatal Hernia Repair

Răzvan Călin Tiutiucă, C Bradea, Paulina Czidziak, Alina Ioana Năstase Pușcașu et autres

Hiatal hernia is a complex pathology, associated with gastroesophageal reflux disease, and for which management involves complex surgical treatment. Knowing the role of gastropexy in reducing postoperative recurrences, the current study aimed to highlight the intraoperative advantages and results of this surgical …

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Hemorrhagic Lithiasic acute Cholecystitis complicated by Cholecystoduodenal Fistula, Mirizzi Syndrome, and Upper Gastrointestinal Bleeding – Clinical, Endoscopic, and Surgical Considerations. Case Report

A Vasilescu

Hemorrhagic acute cholecystitis is a rare and severe form of acute cholecystitis, characterized by intraluminal gallbladder hemorrhage, mural ischemia, and an increased risk of local and systemic complications.Its association with Mirizzi syndrome and biliary-enteric fistula may lead to upper gastrointestinal bleeding, representing …

The Importance of Gastropexy in Minimally Invasive Hiatal Hernia Repair

Răzvan Călin Tiutiucă, Alina Ioana Năstase Pușcașu, Costel Bradea, Paulina Czidziak et autres

Hiatal hernia is a complex pathology, associated with gastroesophageal reflux disease, and whose management involves complex surgical treatment. Knowing the role of gastropexy in reducing postoperative recurrences, the current study aimed to highlight the intraoperative advantages and results of this surgical technique. …

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Global health at crossroads: uniting together to overcome challenges, restore trust and advance priorities for a sustainable future

Massimo Sartelli, Elías Mossialos, Federico Coccolini, Ib Jammer et autres

The world is currently facing an unprecedented convergence of crises that threaten the core pillars of public health, scientific integrity, and social stability. These challenges are profoundly interconnected and have the potential to exacerbate global inequalities, jeopardize health security, and undermine the …

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Heme Oxygenase-1 Expression as a Prognostic Marker in Early-Stage HCC Undergoing Resection or Liver Transplantation

Ramona Cadar, A Vasilescu, Ana-Maria Trofin, Alexandru Năstase et autres

Background: Hepatocellular carcinoma (HCC) is a prevalent malignancy with high mortality, often arising in the context of chronic liver diseases. Heme oxygenase-1 (HO-1), an inducible enzyme involved in heme degradation, has been implicated in both hepatoprotection and tumor progression. This study evaluates …

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Hypothermic Machine Perfusion Is Associated with Improved Short-Term Outcomes in Liver Transplantation: A Retrospective Cohort Study

Alexandru Năstase, A Vasilescu, Ana-Maria Trofin, Mihai Zabara et autres

Introduction: Liver transplantation remains the definitive treatment for end-stage liver disease but faces critical challenges including organ shortages and preservation difficulties, particularly with extended criteria donor (ECD) grafts. Hypothermic machine perfusion (HMP) represents a promising alternative to traditional static cold storage (SCS). …

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Assessment of the Anti-Inflammatory Effectiveness of Diclofenac Encapsulated in Chitosan-Coated Lipid Microvesicles in Rats

Ana-Maria Raluca Pauna, Liliana Mititelu-Tarțău, A Vasilescu, Angy Abu Koush et autres

Background: Diclofenac (DCF) is a widely used nonsteroidal anti-inflammatory drug (NSAID), but its conventional formulations may have limited efficacy and are associated with adverse effects. This study aimed to evaluate the anti-inflammatory and antioxidant effects of diclofenac encapsulated in chitosan-coated lipid microvesicles …

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Isolated Pulmonary Valve Endocarditis Caused by Enterococcus faecalis—Facing the Unpredictable

A Vâţă, Isabela Ioana Loghin, Radu-Ştefan Miftode, Daniela Crișu et autres

Background: Infective endocarditis is a severe, life-threatening condition which affects the endocardial lining of the heart. Right-sided IE typically affects the tricuspid valve and, less commonly, the pulmonary valve, often in association with intravenous drug use and intracardiac devices. Enterococcus faecalis, a …

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Predicting Factor for Occurrence of Postoperative Pancreatic Fistula in Patients with Pancreatic Neuroendocrine Tumors

N Vlad, Florina Delia Andriesi-Rusu, Andrei Chicos, Ana-Maria Trofin et autres

Background: Neuroendocrine tumors are tumors that can develop in any organ but show a predilection for the pancreas. These can be secreting or non-secreting tumors, or they can be well differentiated or poorly differentiated, or neuroendocrine carcinomas. Surgical treatment is the only …

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