Irina Ingold

A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis

Svenja Lorenz, Adam Wahida, Mark J. Bostock, Tobias Seibt et autres

Ferroptosis, driven by uncontrolled peroxidation of membrane phospholipids, is distinct from other cell death modalities because it lacks an initiating signal and is surveilled by endogenous antioxidant defenses. Glutathione peroxidase 4 (GPX4) is the guardian of ferroptosis, although its membrane-protective function remains …

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Author Correction: Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki et autres

In the version of the article initially published, due to a calibration error, values for malondialdehyde (MDA) concentrations reported in the Results, Methods, Fig. 1 and Supp Figs. 1, 2 were underestimated by a factor of five. In the first paragraph of …

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Repression of ferroptotic cell death by mitochondrial calcium signaling

Haitao Wen, Jianwen Chen, Bao Zhao, Shen Wang et autres

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GPX4: old lessons, new features

Thamara Nishida Xavier da Silva, José Pedro Friedmann Angeli, Irina Ingold

GPX4 is a selenocysteine-containing protein that plays an essential role in repairing peroxidised phospholipids. Its role in organismal homeostasis has been known for decades, and it has been reported to play a pivotal role in cell survival and mammalian embryonic development. In …

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Targeting ferroptosis protects against experimental (multi)organ dysfunction and death

Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki et autres

The most common cause of death in the intensive care unit (ICU) is the development of multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure exists, and its mechanisms are still poorly understood. Catalytic iron is associated with ICU mortality and is …

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Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4

Noelia Fradejas‐Villar, Wenchao Zhao, Michael Doengi, Irina Ingold et autres

Selenoproteins are a small family of proteins containing the trace element selenium in form of the rare amino acid selenocysteine (Sec), which is decoded by the UGA codon. In humans, a number of pathogenic variants in genes encoding distinct selenoproteins or selenoprotein …

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Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni et autres

Abstract Acute kidney injury (AKI) is morphologically characterized by a synchronized plasma membrane rupture of cells in a specific section of a nephron, referred to as acute tubular necrosis (ATN). Whereas the involvement of necroptosis is well characterized, genetic evidence supporting the …

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Targeting ferroptosis protects against multiorgan dysfunction and death.

Tom Vanden Berghe, Samya Van Coillie, Ines Goetschalckx, Bartosz Wiernicki et autres

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FSP1 is a glutathione-independent ferroptosis suppressor

Sebastian Doll, Florêncio Porto Freitas, Ron Shah, Maceler Aldrovandi et autres

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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu et autres

High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism. WA dose-dependently either activates the nuclear factor-like 2 pathway through targeting …

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Selenium and iron, two elemental rivals in the ferroptotic death process

Irina Ingold, Marcus Conrad

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Oxidative Stress, Selenium Redox Systems Including GPX/TXNRD Families

Irina Ingold, Marcus Conrad

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