Marcus Conrad

Oxidized phosphatidylinositol impairs lysosomal membrane repair to promote ferroptosis

Shota Fukuyama, Ping-Yen Hsieh, Yuka Jinnouchi, Yuta Matsuoka et autres

Abstract Ferroptosis is a regulated form of cell death driven by iron-dependent and unrestrained lipid peroxidation, which generates phospholipid hydroperoxides that cause membrane rupture. Oxidized phospholipid species, including oxidized arachidonic acid-containing phosphatidylethanolamines (PE), are abundant during ferroptosis. However, previous studies have examined …

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Mechanisms of regeneration and maladaptive repair in acute kidney injury

Tobias Seibt, Konrad Hoeft, Gideon J. L. Schaefer, Adam Wahida et autres

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Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

Abstract Neurodegeneration is a major driver of disability in multiple sclerosis (MS), the most common chronic inflammatory disease of the central nervous system (CNS) 1 . Retinal ganglion cells (RGCs), a heterogeneous neuronal population in the eye, undergo degeneration in MS and …

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Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

This repository contains the processed single-nucleus RNA sequencing data underlying the manuscript "Intracellular complement factor H protects neurons during CNS inflammation". The dataset includes raw count matrices after quality control and corresponding cell-level metadata for human retinal ganglion cells from control donors …

Intracellular complement factor H protects neurons during CNS inflammation

Christina Mayer, Marcel S. Woo, Jana K. Sonner, Lars Binkle-Ladisch et autres

This repository contains the processed single-nucleus RNA sequencing data underlying the manuscript "Intracellular complement factor H protects neurons during CNS inflammation". The dataset includes raw count matrices after quality control and corresponding cell-level metadata for human retinal ganglion cells from control donors …

Resolving the subcellular redox landscape of Coenzyme Q

Tae Ha Kim, Chi Thi Ngoc Nguyen, Dahee Jang, Sae Bom Lee et autres

Coenzyme Q (CoQ) is an essential electron carrier and lipophilic antioxidant whose biological functions depend on its redox state. However, accurate measurement of reduced and oxidized CoQ is hindered by rapid ex vivo oxidation during sample preparation and analysis. Here, we develop …

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Electrophilic monocarbonyl curcumin derivatives reveal differential vulnerabilities in the selenium metabolic network

Wang Yinuo, Takashi Toyama, Hiroyuki Yamakoshi, Hiroki Taguchi et autres

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Targeting ferroptosis in lung cancer

Katherine Wu, Alec Vaughan, Jozef P. Bossowski, Mari N. Nakamura et autres

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Lysosomal membrane-targeting unlocks exceptional ferroptosis suppression

Aditya Upadhyay, Luke A. Farmer, Svenja Lorenz, Alireza Dehdari et autres

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Cytosolic PRDX1 acts as an extramitochondrial sink to set mitochondrial H2O2 levels and enable resilience to chronic mitochondrial oxidative stress

Lianne JHC Jacobs, Sebastian Doll, Dietrich Trümbach, Matteo Veronese et autres

Hydrogen peroxide (H 2 O 2 ) plays a dual role as both a signalling molecule and a mediator of oxidative stress. Although mitochondria are major producers of H 2 O 2 , the relative contributions of mitochondrial versus cytosolic antioxidant systems …

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Cell death in cancer

Marcus Conrad, Andreas Strasser, Philipp J. Jost, Junying Yuan et autres

"Evasion of cell death" is a hallmark of cancer, enabling transformed cells to withstand oncogenic and therapeutic stress. Restoring cancer cell death is an appealing strategy but requires a deep understanding of cell death programs. Over the past two decades, the cell …

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Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Florêncio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich et autres

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