Laura Iulia Bozomitu

Early Gut Microbiota and Neurodevelopmental Trajectories: Implications for Pediatric Neuropsychiatric Vulnerability—A Narrative Review

Vasile Valeriu Lupu, Alin Horațiu Nedelcu, Ingrith Miron, Sorana Caterina Anton et autres

Neurodevelopment is a dynamic and multifactorial process, critical in the early stages of life, involving the formation of neural networks, the establishment of synapses, and the maturation of cognitive, social and emotional circuits. In this context, the gut microbiome emerges as an …

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Thrombosis and Anemia in Pediatric Inflammatory Bowel Disease: Pathophysiology, Clinical Impact and Future Directions

Dragos-Florin Tesoi, Monica Hăncianu, Laura Mihaela Trandafir, Manuela Ciocoiu et autres

Pediatric inflammatory bowel disease (PIBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is associated with inflammation that extends beyond the gastrointestinal tract. Among the most significant extraintestinal complications are anemia and thrombosis, both of which can impact disease severity, quality of …

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Biomarkers and Mechanisms in the Early Assessment of Childhood Obesity from a Multidisciplinary Perspective—A Narrative Review

Dana Elena Mîndru, Laura Iulia Bozomitu, Dana-Teodora Anton-Păduraru, Elena Țarcă et autres

Obesity has been the subject of research focused on preventive policies among the young population due to epidemiological studies which have shown devastating figures in recent years in terms of the incidence and prevalence of this condition. A number of previously known …

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Fetal Growth Restriction and Its Metabolism-Related Long-Term Outcomes—Underlying Mechanisms and Clinical Implications

Anca Adam-Raileanu, Ingrith Crenguța Miron, Laura Iulia Bozomitu, Maria Oana Săsăran et autres

The developmental origins of adult disease theory support the concept that undernourished fetuses are at risk of developing metabolic syndrome due to the energy-saving 'Thrifty Phenotype'. This metabolic plasticity represents an evolutionary adaptation that allows individuals to resist the intense pressure caused …

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Identifying Childhood Risk Factors for Hepatitis B with a Focus on Vertical Transmission

Lorenza Forna, Ancuța Lupu, Laura Iulia Bozomitu, Gabriela Păduraru et autres

BACKGROUND: Despite worldwide vaccination efforts, Hepatitis B virus (HBV) infection remains a significant global health burden, particularly in regions where vertical transmission is prevalent. Given Romania's history as an endemic area for hepatitis B from the 1990s until the early 2000s and …

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Pediatric Perspectives on Liver Cirrhosis: Unravelling Clinical Patterns and Therapeutic Challenges

Lorenza Forna, Laura Iulia Bozomitu, Vasile Valeriu Lupu, Ancuța Lupu et autres

Background: Liver cirrhosis presents significant challenges in the pediatric population due to a complex interplay of etiological factors, clinical manifestations, and limited therapeutic options. The leading contributors to cirrhosis among pediatric patients are chronic cholestasis, metabolic disorders present from birth, and long-term …

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Insights into the Natural and Treatment Courses of Hepatitis B in Children: A Retrospective Study

Lorenza Forna, Laura Iulia Bozomitu, Ancuța Lupu, Vasile Valeriu Lupu et autres

Chronic Hepatitis B virus (HBV) infection in children remains a significant public health challenge. The natural history and treatment outcomes of HBV can vary widely, influencing management strategies. This retrospective study was conducted in Northeast Romania and involved a cohort of 148 …

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ORAL MANIFESTATIONS OF ANOREXIA IN ADOLESCENT PATIENTS

Gabriela Păduraru, Gabriela Ghiga, Nicoleta Gimiga, Vasile Valeriu Lupu et autres

The aim of the study is to analyse and discuss the main mucosal, dental and cutaneous manifestations in the oral area associated with anorexia in adolescent patients, in order to raise awareness among healthcare providers and caregivers about the specific oral health …

Exploring the Microbial Landscape: Gut Dysbiosis and Therapeutic Strategies in Pancreatitis—A Narrative Review

Vasile Valeriu Lupu, Roxana Bratu, Laura Mihaela Trandafir, Laura Iulia Bozomitu et autres

The gut microbiota is emerging as an important contributor to the homeostasis of the human body through its involvement in nutrition and metabolism, protection against pathogens, and the development and modulation of the immune system. It has therefore become an important research …

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Diagnosis and Management of Gastrointestinal Manifestations in Children with Cystic Fibrosis

Dana-Teodora Anton-Păduraru, Alina Mariela Murgu, Laura Iulia Bozomitu, Dana Elena Mîndru et autres

Cystic fibrosis (CF) is primarily known for its pulmonary consequences, which are extensively explored in the existing literature. However, it is noteworthy that individuals with CF commonly display gastrointestinal (G-I) manifestations due to the substantial presence of the cystic fibrosis transmembrane conductance …

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Afectarea hepatică în mucoviscidoză

Bogdan Aurelian Stana, Laura Iulia Bozomitu, Sabina Grigoraş, Paula Popovici

Among the systemic impairment in cystic fibrosis there is also hepatobiliary tract involvement, with some genetic determinants of the disease manifesting as cystic fibrosis-associated liver disease (CFLD). The pathogenesis, natural history and cyrrhogenic evolution of CFLD are discussed in relation to the …

Emerging role of the gut microbiome in post-infectious irritable bowel syndrome: A literature review

Vasile Valeriu Lupu, Cristina Mihaela Ghiciuc, Gabriela Ștefănescu, Cristina Maria Mihai et autres

Post-infectious irritable bowel syndrome (PI-IBS) is a particular type of IBS, with symptom onset after an acute episode of infectious gastroenteritis. Despite infectious disease resolution and clearance of the inciting pathogen agent, 10% of patients will develop PI-IBS. In susceptible individuals, the …

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