Andrew Whyte

P23 A survey of physician practice, knowledge and attitudes towards penicillin allergy labels and penicillin desensitization in the intensive care unit

John E A Taylor, Neil Powell, Andrew Whyte, Rob Jackson et autres

Abstract Background Penicillin allergy labels are reported in approximately 10% of patients, yet over 90% of these labels are inaccurate when formally tested. This mislabelling has important implications for antimicrobial stewardship, as it leads to avoidance of first-line β-lactam antibiotics, resulting in …

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Prevalence of KIT D816V in anaphylaxis or systemic mast cell activation

Karin Hartmann, Iván Álvarez‐Twöse, Jonathan A. Bernstein, Cem Akin et autres

BACKGROUND: The KIT D816V mutation is a hallmark of clonal mast cell disease (cMCD) including systemic mastocytosis. cMCD diagnosis is frequently delayed because of variable symptoms until confirmatory bone marrow biopsy is performed. Screening techniques for KIT D816V variant in peripheral blood …

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Equivalent Outcomes Following Submerged or Trans-Mucosal Guided Bone Regeneration Procedures Using a Bioactive Collagen Membrane: A Prospective Case Series

Brent Allan, Rudolf Boeddinghaus, Andrew Whyte, Mithran S. Goonewardene et autres

PURPOSE: To compare the clinical and radiographic outcomes of patients receiving two different healing strategies for their guided bone regeneration (GBR) procedures using a novel collagen membrane to support the implant placement. MATERIALS AND METHODS: A total of 20 patients (27 implants) …

A multi-centre UK-based survey on angioedema secondary to acquired C1 inhibitor deficiency

Hadeil Morsi, Aarnoud Huissoon, Alexandros Grammatikos, Andrew Whyte et autres

BACKGROUND: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterization of the AAE-C1-INH cohort in the UK is required to inform management. OBJECTIVES: To describe the disease burden of AAE-C1-INH, long-term prophylaxis …

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Optic Neuritis Post Immune Checkpoint Inhibitor Therapy

May Ameri, Andrew Whyte, Nagham Al‐Zubidi

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Cover Feature: Synthesis and Thermodynamic Evaluation of Sialyl‐Tn MUC1 Glycopeptides Binding to Macrophage Galactose‐Type Lectin (ChemBioChem 18/2024)

Ramya Ayyalasomayajula, Ivet Boneva, David Ormaza, Andrew Whyte et autres

Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to Tn and sialyl-Tn MUC1 glycopeptides revealed a dynamic process in which lectin molecules bind to carbohydrate ligands and jump from ligand to ligand along the glycopeptides’ backbone. More details can be …

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Synthesis and Thermodynamic Evaluation of Sialyl‐Tn MUC1 Glycopeptides Binding to Macrophage Galactose‐Type Lectin

Ramya Ayyalasomayajula, Ivet Boneva, David Ormaza, Andrew Whyte et autres

Interactions between the tumor-associated carbohydrate antigens of Mucin 1 (MUC1) and the carbohydrate-binding proteins, lectins, often lead to the creation of a pro-tumor microenvironment favoring tumor initiation, progression, metastasis, and immune evasion. Macrophage galactose binding lectin (MGL) is a C-type lectin receptor …

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Prevalence Of The KIT D816V Mutation In Peripheral Blood (PB) Of Patients With Evidence Of Systemic Mast Cell Activation (MCA): Results Of The Prospective, Multi-centered, Global PROSPECTOR Clinical Trial

Karin Hartmann, Iván Álvarez‐Twöse, Bethan Myers, Albert Hirdt et autres

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An Uncommon Case of Multiple, Recurrent Cerebrospinal Fluid Venous Fistulas

May Ameri, Andrew Whyte, Stephen Chen, Andrew G. Lee et autres

We present a clinical case to discuss the use of computed tomography (CT) spine myelograms alongside a complete history to diagnose multiple cerebrospinal fluid (CSF) venous fistulas (CVFs). The goal of this study is to familiarize clinicians with this challenging diagnosis and …

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Ocular Toxicity Profile of Targeted Cancer Therapy (TCT) at a US Tertiary Cancer Center

Moe Ameri, Nagham Al‐Zubidi, Azadeh Razmandi, Andrew Whyte et autres

PURPOSE: Targeted cancer therapy (TCT) is a significant advancement in oncology with promising survival improvement in patients with cancer and remarkable effects on various cancers. There is evidence suggesting a connection between specific TCT classes and the occurrence of immune-related adverse events …

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Chronic or recurrent Campylobacter enteritis in primary immunodeficiency: A UK national case-series and review of the literature

Alexandros Grammatikos, Moira Thomas, Sarah Johnston, Fiona Moghaddas et autres

Campylobacter infection, usually by Campylobacter jejuni, is the most common cause of bacterial enteritis in the world. In healthy individuals, the infection is self-limiting, but in patients with immunodeficiency, recurrent or persistent symptomatic infection may occur. In this case series, we present …

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Emergency treatment of anaphylaxis: concise clinical guidance

Andrew Whyte, Jasmeet Soar, Anna Hughes, Nicholas Sargant et autres

Anaphylaxis is a serious systemic hypersensitivity reaction that is usually rapid in onset and may cause death. It is characterised by the rapid development of airway and/or breathing and/or circulation problems. Intramuscular adrenaline is the most important treatment, although, even in healthcare …

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