Yue Chen

Geriatric syndromes and intrinsic capacity in older adults with coronary heart disease: a cross-sectional study in China

Jiaojiao Qiu, Shuaishuai Zhang, Yue Chen, Yan Wang et autres

Background: Geriatric syndromes (GS) are highly prevalent among community-dwelling older adults with self-reported physician-diagnosed coronary heart disease (CHD), but their association with intrinsic capacity (IC) remains poorly characterized. Methods: We analyzed cross-sectional data from 5,835 community-dwelling Chinese older adults with self-reported physician-diagnosed …

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Exercise ameliorates adipose tissue insulin resistance by activating the lactate/GPR81 signaling pathway in DIO-IR mice

Yihsuan Lin, Ge Song, Yue Chen, Chunyu Liang et autres

Exercise-induced lactate as a critical signaling molecule that ameliorates insulin resistance in obesity. Lactate enhances adipose tissue glucose uptake and rebalances adipokine secretion by upregulating the receptor G protein-coupled receptor 81 (GPR81). The findings establish lactate as an essential exercise metabolite with …

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Relationship between serum mineral levels in the second and third trimester of pregnancy and the risk of gestational diabetes mellitus: a retrospective cohort study

Yuxin Hao, Na Wang, Sumiao Hong, Yongyi Liu et autres

Introduction Gestational diabetes mellitus (GDM) poses significant health risks for both the mother and fetus, and it also increases the mother’s risk of developing type 2 diabetes later in life. Mineral elements may play a crucial role in the development of GDM …

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Ligation-Triggered Assay for the Signal-Amplified Genotyping of Cancer-Associated Single Nucleotide Polymorphisms in MicroRNAs

Wei Lv, Furong Zhao, Heng Gao, Yue Chen et autres

Methods for detecting microRNA (miRNA) are well-established, yet strategies for identifying miRNA-related single-nucleotide polymorphisms (miR-SNPs) remain limited. Despite their strong association with cancer development, the clinical application of miR-SNPs has been hindered by the lack of practical detection methods. To bridge this …

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Caries Control by CAPE Toothpaste: In Vitro, In Vivo, and In Situ Analysis

Yufei Wang, Shihua Dong, Yue Chen, Yuhong Zeng et autres

Dental caries is closely associated with microbiome dysbiosis. Incorporating antimicrobial agents can enhance the efficacy of fluoride toothpaste. Our previous studies showed that caffeic acid phenethyl ester (CAPE), derived from propolis, effectively inhibited cariogenic bacteria. To formulate a novel CAPE-containing fluoridated toothpaste …

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Sex-specific dynamic changes of serum short-chain fatty acids in rhesus monkeys during aging

Xiaopeng Chen, S.W. Ye, Juncai Pu, Siwen Gui et autres

BACKGROUND: The potential association between short-chain fatty acids (SCFAs) and aging has gained increasing research attention. Although most studies have focused on fecal SCFAs, limited attention has been directed toward SCFAs in peripheral blood. Furthermore, this relationship remains insufficiently explored in non-human …

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The multimodal anti-tumor effect of cisplatin nanoparticles loaded with bacterial antibodies in combination with radiotherapy: targeting hypoxic tumor and reshaping of the immune microenvironment

Zhouxue Wu, Weizhou Wang, Yunxue Zheng, Hongxia Li et autres

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Intrapulmonary Castleman disease mimicking locally advanced primary lung cancer on 18F-FDG PET/CT

Di Yan Huang, Xiaonan Yang, Yue Chen, Jie Gong

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1012eP DR510: A dual-masking T cell engager prodrug with single-site cleavage for balancing efficacy and safety in solid tumor therapy

Xiaohui Wen, Gao-sheng Yao, Wengui Duan, Ziwen Zhou et autres

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Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Yingyi Li, Ziwei Yan, Yue Chen, Yuyi Chen et autres

Macrophages and bone marrow mesenchymal stem cells (BMSCs) share a close relationship within the osteoimmune microenvironment. During mechanically induced bone formation, macrophages respond to stimuli and regulate this microenvironment, influencing BMSCs' proliferation and differentiation. However, the underlying mechanisms remain incompletely understood. In …

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WED-295 Comparative efficacy and safety of tenofovir amibufenamide vs tenofovir alafenamide and entecavir in the hepatitis B virus related acute-on-chronic liver failure patients: a single-centre retrospective study

Xiangwen Diao, Qianjun Wu, M. H. Gu, Fei Huang et autres

Baseline Characteristics of Idiopathic Pulmonary Fibrosis and Systemic-sclerosis-associated Interstitial Lung Disease Patients Enrolled in the Moonscape Study of Vixarelimab

J.W. Song, Tracy Luckhardt, B. Crestani, David A. Zisman et autres

Abstract RATIONALE More effective treatments are needed for patients with idiopathic pulmonary fibrosis (IPF) and systemic-sclerosis-associated interstitial lung disease (SSc-ILD). Vixarelimab is an investigational, first-in-class, fully human, monoclonal antibody that targets oncostatin M receptor-beta (OSMRβ). OSMRβ is a cytokine receptor subunit that …

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