Relationship between serum mineral levels in the second and third trimester of pregnancy and the risk of gestational diabetes mellitus: a retrospective cohort study
Rattachement africain : cn, us, ca. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction Gestational diabetes mellitus (GDM) poses significant health risks for both the mother and fetus, and it also increases the mother’s risk of developing type 2 diabetes later in life. Mineral elements may play a crucial role in the development of GDM by influencing insulin metabolism. However, comprehensive studies on serum mineral levels during pregnancy remain limited. This study aims to evaluate the relationship between serum mineral levels in pregnant women during the second and third trimesters and the risk of developing GDM. Methods This retrospective cohort study included 17,224 singleton pregnancies delivered between 2016 and 2022 at a tertiary hospital in China. Maternal demographic data and serum mineral concentration information from the mid and late stages of pregnancy were collected through the hospital information system. Analyses were conducted using restricted cubic spline models and multivariate logistic regression models. Results The prevalence of GDM in this study was 15.07%. Chloride [ P for overall = 0.01; P for non-linear = 0.373; OR (95% CI) = 1.03 (1.01, 1.05)] showed a significant linear positive association with GDM. Additionally, serum levels of calcium ( P for non-linear < 0.001), potassium ( P for nonlinear = 0.036), and magnesium (P for nonlinear < 0.001) were found to have non-linear relationships with the risk of GDM. The interactions between calcium and magnesium [OR (95% CI) = 0.05 (0.01, 0.27), P for interaction < 0.001], potassium and magnesium [OR (95% CI) = 0.11 (0.03, 0.37), P for interaction < 0.001], and potassium and chloride [OR (95% CI) = 1.06 (1.01, 1.11), P for interaction < 0.001] were significant. Discussion The study indicates that specific serum mineral levels in pregnant women are closely associated with the risk of gestational diabetes mellitus. A deeper understanding of the mechanisms and interactions of these minerals could aid in developing effective prevention and treatment strategies, thereby reducing the incidence of GDM and improving pregnancy outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Relationship between serum mineral levels in the second and third trimester of pregnancy and the risk of gestational diabetes mellitus: a retrospective cohort study
- Date Crossref
- 29/10/2025
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Fudan University pays non établi dans la noticeUniversité ou école supérieure
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Wenzhou City People's Hospital pays non établi dans la noticeÉtablissement de santé
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Columbia University pays non établi dans la noticeUniversité ou école supérieure
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University of Ottawa pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health Key Lab of Health Technology Assessment of Ministry of Health pays non établi dans la noticeUniversité ou école supérieure
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The People's Hospital of Pingyang Department of Obstetrics pays non établi dans la noticeÉtablissement de santé
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Wenzhou Center for Disease Control and Prevention pays non établi dans la noticeInstitution
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School of Epidemiology and Public Health pays non établi dans la noticeUniversité ou école supérieure
Fudan University, Wenzhou City People's Hospital et Columbia University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.