L.R. Chen

Digital Twins for Marine Robotic Platforms: Architectures, Applications, and Challenges Across AUVs, ROVs, USVs, Underwater Gliders, and Emerging Platforms

Xuehao Wang, L.R. Chen, Dongyang Xue, Cheng Chen et autres

Digital twin (DT) research spans autonomous underwater vehicles (AUVs), remotely operated vehicles (ROVs), unmanned surface vessels (USVs), underwater gliders, and emerging marine robotic platforms; however, reported systems differ widely in terms of their physical–virtual coupling and validation maturity. A structured Web of …

cn (code pays fourni par la source)

Acoustics-Driven Performance Enhancement in Underwater Vehicles: From Component Innovation to Intelligent Actuation

Xuehao Wang, Zihao Wang, L.R. Chen, Yaqiang Zhu et autres

Underwater vehicles (UVs) are pivotal for ocean exploration, yet their effectiveness is fundamentally constrained by acoustic performance in noisy and dynamic seas. Self-noise, non-stationary interference, and extreme conditions not only degrade sensing, navigation, and stealth but also cascade into losses in propulsion …

cn (code pays fourni par la source)

Deeptfgp: deep learning-based traffic flow graph prediction

Guangxu Bian, Yuanfang Chen, Muhammed Alam, L.R. Chen et autres

Traffic flow prediction is a crucial aspect of transportation planning to prevent congestion. A good understanding of a traffic planning strategy will assist in avoiding traffic congestion. Complex factors, such as inter-region traffic conditions, vehicle relationships, and unexpected incidents, influence accurate traffic …

cn, gb (code pays fourni par la source)

Elastic FWI application on shallow water area using ocean bottom data

Bin Yu, ChangHua Zhang, X.W. Liu, Mingqiu Luo et autres

Full-Waveform Inversion (FWI) has emerged as a powerful tool for improving seismic imaging by utilizing the full wavefield information, including both transmitted and reflected waves. In a shallow water oil field of China, the complex high structural configurations with the complex fault …

cn (code pays fourni par la source)

PS tomography with cross-correlation-based event matching

X.W. Liu, Bin Yu, Mingqiu Luo, Miao Liu et autres

Seismic PS images can complement conventional PP images, especially where PP images cannot effectively illuminate, e.g., below gas pockets. However, building reliable Vs migration velocity is crucial to achieve high-quality PS images, which is not trivial. Here we propose a raytracing-based PS …

cn (code pays fourni par la source)

Industry Practices in Oligonucleotide Tissue Biodistribution Assessment: An IQ consortium Cross-Industry Survey of Current Approaches and Emerging Trends

Michael McCoy, Huaping Tang, Lydia Michaut, Irina Laczkovich et autres

Accurate assessment of tissue distribution for oligonucleotide therapeutic (ONT) drug candidates is essential for understanding pharmacokinetic behavior and predicting therapeutic efficacy. ONTs present a unique challenge with their rapid systemic clearance coupled with prolonged tissue retention, making comprehensive tissue concentration evaluation critical …

jp, us, ch, dk, br (code pays fourni par la source)

Causal-Guided Detoxify Backdoor Attack of Open-Weight LoRA Models

L.R. Chen, Yang Sun, Hongru Wei, Yuqi Chen

Low-Rank Adaptation (LoRA) has emerged as an efficient method for fine-tuning large language models (LLMs) and is widely adopted within the open-source community.However, the decentralized dissemination of LoRA adapters through platforms such as Hugging Face introduces novel security vulnerabilities: malicious adapters can …

cn (code pays fourni par la source)

Causal-Guided Detoxify Backdoor Attack of Open-Weight LoRA Models

L.R. Chen, Yang Sun, Hongru Wei, Yuqi Chen

Low-Rank Adaptation (LoRA) has emerged as an efficient method for fine-tuning large language models (LLMs) and is widely adopted within the open-source community. However, the decentralized dissemination of LoRA adapters through platforms such as Hugging Face introduces novel security vulnerabilities: malicious adapters …

Causal-Guided Detoxify Backdoor Attack of Open-Weight LoRA Models

L.R. Chen, Yang Sun, Hongru Wei, Yuqi Chen

Low-Rank Adaptation (LoRA) has emerged as an efficient method for fine-tuning large language models (LLMs) and is widely adopted within the open-source community. However, the decentralized dissemination of LoRA adapters through platforms such as Hugging Face introduces novel security vulnerabilities: malicious adapters …

cn (code pays fourni par la source)

2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide & Bicycle Drug Conjugates ( PART 1A – Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing & Reporting PART 1B – Regulatory Agencies’ Input on Regulated Bioanalysis/BMV)

John Wojcik, Mark G. Qian, Anton I. Rosenbaum, Estelle M. Maes et autres

The 19th Workshop on Recent Issues in Bioanalysis (19th WRIB) took place in New Orleans, LA, USA on April 7-11, 2025. Over 1200 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest …

jp, fr, us, de, Égypte, es, nl, br, ca, ch, cn, gb, it, il (code pays fourni par la source)

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation

Jing Wang, Xiaoqian Deng, Shanshan Yin, L.R. Chen et autres

us, cn (code pays fourni par la source)

Enucleation after fusion and activation enhances the development of reconstructed bovine embryos

Weijia Cheng, B.T. Liu, Hui Su, J.W. Lee et autres

tw (code pays fourni par la source)