Lawrence J. Mandarino

Selective advantages, selective mismatches, chronic inflammation, obesity, and type 2 diabetes: a new hypothesis to explain the effects of natural selection on genetic variation at the ectodysplasin A receptor locus

Dawn K. Coletta, Leslea J. Hlusko, G Richard Scott, Yann Klimentidis et autres

Development of ectodermal tissues in humans is a complex process regulated by interacting signaling pathways. This review adopts an evolutionary medicine framework to examine how genetic variation in components of the ectodysplasin A (EDA) signaling pathway may have conferred human evolutionary fitness …

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Restoration of oxidative stress by HNF4α deletion in VWA8-null hepatocytes

Moulun Luo, Wuqiong Ma, Rocio Zapata Bustos, Dawn K. Coletta et autres

VWA8 is a mitochondrial protein expressed at high levels in mitochondria-enriched organs such as the liver, kidney, and heart. Deletion of VWA8 (VWA8-KO) in AML12 mouse hepatocytes leads to oxidative stress characterized by elevated production of reactive oxygen species (ROS) and, subsequently, …

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1391-P: Plasma Proteomic Risk Modeling of Chronic Kidney Disease Progression in Latino Adults with Diabetes

DAWN K. COLETTA, NASRIN FATIMA, KAYLA MCCABE, Oscar D. Parra et autres

Introduction and Objective: Chronic kidney disease (CKD) affects ~10% of adults worldwide, with diabetes as a major driver. Although plasma proteomic risk scores have shown promise for predicting CKD progression, these models have largely been developed in populations that underrepresent Latino individuals. …

2639-P: Association between Sleep Apnea and Metabolic Syndrome Traits in El Banco Community Biobank

PAYTON KILRAIN, NASRIN FATIMA, Lisa F. Soltani, Yann Klimentidis et autres

Introduction and Objective: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) disorders contribute to adverse cardiovascular events. OSA involves the repeated collapse of the upper airway, leading to partial or complete cessation of airflow. MetS is characterized by increased triglycerides, hypertension, decreased …

1563-P: External Motivation, Restlessness with Inactivity, and Enjoyment: Examining Associations with Physical Activity in El Banco Por Salud

Sophia Stevens, NASRIN FATIMA, Yann Klimentidis, Oscar D. Parra et autres

Introduction and Objective: Despite strong evidence that regular physical activity improves glycemic control and metabolic health, most adults remain insufficiently active. Understanding motivational pathways that support sustained physical activity is critical for effective clinical interventions. Guided by Self-Determination Theory, this study examined …

1126-OR: MALAT1 Is an Exercise-Responsive Regulatory RNA Associated with Metabolic Traits

Erin N. Schuette, NASRIN FATIMA, Lawrence J. Mandarino, DAWN K. COLETTA

Introduction and Objective: Chronic inflammation contributes to insulin resistance and type 2 diabetes, yet regulatory RNAs linking metabolic disease to modifiable lifestyle factors remain poorly understood. The long non-coding RNA MALAT1 regulates transcriptional and inflammatory signaling, but its role in metabolic health …

2414-P: Skin Inflammation as a Mediator of Metabolic Dysfunction: The Role of EDARV370A Genetic Variation

DAWN K. COLETTA, Sunny Palumbo, NASRIN FATIMA, Erin N. Schuette et autres

Introduction and Objective: Chronic inflammation contributes to obesity and type 2 diabetes, yet little is known about subclinical skin inflammation in metabolic disease. Prior work from our group revealed that carriers of the alanine variant of the EDAR gene (EDARV370A) have higher …

Genetic substructure in Latin American individuals reveals novel associations, mechanistic insights, and variable polygenic risk score transferability for alcohol traits

Janitza Montalvo-Ortiz, José Martínez-Magaña, Diego Andrade Brito, Eirini Trichia et autres

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Restoration of Oxidative Stress by HNF4α Deletion in VWA8-null Hepatocytes

Moulun Luo, Wuqiong Ma, Rocio Zapata-Bustos, Dawn K. Coletta et autres

Medical nutrition therapy for the management of type 2 diabetes mellitus

Luigi Barrea, Ludovica Verde, Annamaria Colao, Lawrence J. Mandarino et autres

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Excessive Daytime Sleepiness and Associated Cardiometabolic Factors in Latino Individuals of Mexican Ancestry at High Risk of Type 2 Diabetes: An El Banco Biobank Cross-Sectional Study

Ludovica Verde, Dawn K. Coletta, Yann C. Klimentidis, Lisa Soltani et autres

Background/Objectives: Latinos, particularly those of Mexican ancestry, experience high rates of type 2 diabetes and sleep disturbances, exacerbating adverse health outcomes. This study aimed to examine the prevalence of excessive daytime sleepiness and its associations with diet, cardiometabolic risk factors, and glycemic …

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The Interplay of UCP3 and PCSK1 Variants in Severe Obesity

Ludovica Verde, Dawn K. Coletta, Silvia Savastano, Lawrence J. Mandarino et autres

Obesity is a heterogeneous and multifactorial disease with a strong genetic component. While polygenic obesity accounts for most common cases, rare monogenic variants contribute, particularly in severe, early-onset obesity. Among the lesser-studied candidates are UCP3 and PCSK1, genes involved in key metabolic …

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