Fiorenza Rancan

Quatsome nanovesicles as antibacterial platform: Mechanistic insights into their activity against planktonic and biofilm Staphylococcus aureus

Mariana Korber, Amparo Maria Gallardo-Moreno, Lidia Ferrer‐Tasies, María Coronada Fernández‐Calderón et autres

Quatsome nanovesicles as antibacterial platform: Mechanistic insights into their activity against planktonic and biofilm Staphylococcus aureus

Mariana Köber, Amparo Maria Gallardo-Moreno, Lidia Ferrer‐Tasies, María Coronada Fernández‐Calderón et autres

The growing threat of antibiotic-resistant pathogens has intensified the demand for alternative antibacterial materials. Quatsomes-nanovesicles composed of cholesterol and quaternary ammonium surfactants (QAS)-emerge as promising candidates due to their intrinsic antimicrobial properties and tunable physicochemical characteristics. Here, we investigate the antibacterial activity …

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Polyglycerol-b-polyoxazoline: A next-generation biocompatible agent for diabetic wound treatment

Fatemeh Zabihi, Siamak Beyranvand, Zahra Mohammadi, Zahra Mohammadi et autres

Diabetic wounds remain a major clinical challenge due to persistent inflammation and impaired tissue regeneration. In this study, we report the scalable synthesis of hyperbranched polyglycerol-b-poly(2-ethyl-2-oxazoline) star copolymers bearing terminal arginine groups (hPG-b-PEO-Arg), designed to self-assemble into nanoscale hydrocolloids (70-200 nm) in …

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Skin and Wound Infection Models to Test Host–Pathogen Interactions and Evaluate Topical Antimicrobial Treatments

F. Schwarz, Christin Tautz, A. M. Nitsche, Marica Grossegesse et autres

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Improving the Culture of Human Skin Explants for Use in Preclinical Testing of Wound Healing Treatments

Xiao Ping Guo, Martina Hüging, Ursula Mirastschijski, Ulrike Blume‐Peytavi et autres

Background: Cultured human skin explants provide preclinical models to investigate drug delivery and the efficacy of topical treatments for wound healing. However, different culture conditions may affect cell viability, proliferation, and even wound healing. Since animal-derived supplements can influence the investigation of …

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Surface functionalization of multilayer nanoparticles with hyaluronic acid or alternative polymers: Effects on cellular uptake and re-epithelialization in a human ex vivo wound model

Maria Angela Motta, Ulyana Semenko, Upashi Goswami, Zixiao Zhao et autres

Prolonged inflammation and microbial infections are the main issues that slow down the healing process. To improve wound repair, remarkable advances in nanotechnology have enabled the development of nanomaterials with multifunctional features, including antibacterial, anti-inflammatory, and pro-angiogenic properties. In this study, the …

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Bioactive bacterial nanocellulose membranes for non-surgical debridement and infection prevention in burn wound healing

Urška Jančič, Isabella Nacu, Liliana Vereștiuc, Fiorenza Rancan et autres

Novel bioactive bacterial nanocellulose (BnC) membranes were developed for effective, non-surgical debridement and infection-prevention in burn wound healing. Membranes were modified in situ with carboxymethyl cellulose (CMC) and ex situ with the proteolytic enzyme bromelain (Br) and antimicrobial peptide nisin (N). Post-processing …

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Scanning Transmission Soft X‐Ray Microscopy Probes Topical Drug Delivery of Rapamycin Facilitated by Microneedles

Johann Moritz Laux, Takuji Ohigashi, Marius R. Bittermann, Tohru Araki et autres

Scanning Transmission X-ray microscopy (STXM) is a sensitive and selective probe for the penetration of rapamycin which is topically applied to human skin ex vivo and is facilitated by skin treatment with microneedles puncturing the skin. Inner-shell excitation serves as a selective …

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Modulating the immune system towards a functional chronic wound healing: A biomaterials and Nanomedicine perspective

Kevin Las Heras, Itxaso García-Orue, Fiorenza Rancan, Manoli Igartúa et autres

Chronic non-healing wounds persist as a substantial burden for healthcare systems, influenced by factors such as aging, diabetes, and obesity. In contrast to the traditionally pro-regenerative emphasis of therapies, the recognition of the immune system integral role in wound healing has significantly …

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Effects of a leave‐on product on the strength of the dermoepidermal junction: An exploratory, intraindividual, randomized controlled trial in older adults with dry skin

Ruhul Amin, Fiorenza Rancan, Kathrin Hillmann, Ulrike Blume‐Peytavi et autres

Background and Aims: Skin aging is associated with dry skin and a decrease of the strength of the dermoepidermal adhesion, which increases the risk for lacerations (skin tears). Application of leave-on products improves dry skin and seems to reduce skin tear incidence. …

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Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates

Fatemeh Zabihi, Mariam Cherri, Xiao Ping Guo, Fiorenza Rancan et autres

Inflammatory skin diseases, such as psoriasis, atopic dermatitis, and alopecia areata, occur when the regulatory tolerance of the innate immune system is disrupted, resulting in the activation of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) inflammatory signaling pathway by interleukin …

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Synthesis of C 3 -symmetric star shaped amphiphiles for drug delivery applications

Ayushi Mittal, Aarti Aarti, Sudhanshu Vats, Fatemeh Zabihi et autres

click and esterification reactions, respectively, to produce a new type of star shaped amphiphiles. So the obtained amphiphilic architectures have a tendency to aggregate in an aqueous medium forming nanosized assemblies with an inner hydrophobic core, allowing the substituents to control the …

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