Lihui Lu

ATRX large deletions and truncating mutations are associated with primary induction chemotherapy resistance in high-risk neuroblastoma: a multicenter propensity-weighted cohort study

Jing Sun, Bo Qian, Lihui Lu, Zhou Jf

Background: ATRX alterations are adverse prognostic factors in high-risk neuroblastoma patients. However, the precise impact of distinct ATRX mutation subtypes-particularly multiexon deletions versus missense mutations-on response to standard-of-care multiagent induction chemotherapy remains poorly defined. Methods: This multicenter retrospective cohort study evaluated newly …

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Temperature-dependent performance of zeolite/MOF hybrid membranes for CO₂ separation and water purification: A molecular dynamics study

Lihui Lu, Zhenbang Tian, Mokhtar Hamedinia

Molecular dynamics simulations are performed on zeolite/metal-organic framework hybrid membranes in this study to analyze CO₂-selective separation and water purification properties at 300–340 K. Temperature also yields considerable differences in the extent of all transport, adsorption, and fouling behaviors. The increase in …

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DKK3 as a novel biomarker for risk stratification in pediatric acute lymphoblastic leukemia

Wenpeng Wang, Feng Zhu, Pei Li, DaWei Mi et autres

Introduction Aberrant Wnt signaling drives oncogenesis. DKK proteins, key extracellular regulators of Wnt pathway, play critical roles in tumor suppression or promotion.Methods This study enrolled 66 newly diagnosed acute lymphoblastic leukemia (ALL) patients, stratified into low-risk (LR) and intermediate/high-risk (IR/HR) groups, alongside …

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Neuroendocrine circuit for sleep-dependent growth hormone release

Xinlu Ding, Fuu-Jiun Hwang, Daniel N. Silverman, Peng Zhong et autres

Sleep is known to promote tissue growth and regulate metabolism, partly by enhancing growth hormone (GH) release, but the underlying circuit mechanism is unknown. We demonstrate how GH release, which is enhanced during both rapid eye movement (REM) and non-REM (NREM) sleep, …

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Upcycling Post-Consumer Polyvinyl Chloride (Pvc) Pipes into Inherently Antibacterial Materials Through Quaternary Ammonium Functionalization

Lihui Lu, Yangyang Chang, Xiaozheng Li, Ying Cheng et autres

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Luteolin-7-O-β-d-Glucuronide Attenuated Cerebral Ischemia/Reperfusion Injury: Involvement of the Blood–Brain Barrier

Xing Fan, Jintao Song, Shuting Zhang, Lihui Lu et autres

Hance, a Chinese medicinal herb mainly used for the treatment of coronary heart disease, angina pectoris, cerebral infarction, etc. In the present study, the protective effect of LGU on cerebral ischemia/reperfusion injury was investigated in an oxygen-glucose deprivation/reoxygenation (OGD/R) neuronal model and …

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Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1

Kunlong Zhang, Jun Lu, Fang Fang, Yongping Zhang et autres

Background. Arising from T progenitor cells, T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor, accounting for 15% of childhood ALL and 25% of adult ALL. Composing of putative enhancers in close genomic proximity, super enhancer (SE) is critical for …

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BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3

Li Ma, Jianwei Wang, Yang Yang, Jun Lü et autres

INTRODUCTION: B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit high mortality rates. MZ1, a novel inhibitor of Bromodomains and …

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LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1

Lihui Lu, Jianwei Wang, Fang Fang, Ailian Guo et autres

One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator of hematopoietic stem cell development and erythropoiesis, LMO2 is considered an effective carcinogenic …

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BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3

Li Ma, Jianwei Wang, Yang Yang, Jun Lü et autres

B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit high mortality rates. MZ1, a novel inhibitor of Bromodomains and extra-terminal …

BRD4 PROTAC degrader MZ1 exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B genes

Li Ma, Jianwei Wang, Yongping Zhang, Fang Fang et autres

Acute myeloid leukemia (AML) is a highly cancerous and aggressive hematologic disease with elevated levels of drug resistance and relapse resulting in high mortality. Recently, bromodomains and extra-terminal (BET) protein inhibitors have been extensively researched in hematological tumors as potential anticancer agents. …

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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia

Xu Sang, Yongping Zhang, Fang Fang, Lijun Gao et autres

Background: AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have shown that as a novel BRD4 (bromodomain containing 4) PROTACs (proteolysis targeting chimeras) degrader, GNE-987 can slow down the growth …

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