Accès ouvert
2025
article
OpenAlex
Malte Suchan, Nora Wuerdemann, Steffen Wagner, Christine Langer et autres
INTRODUCTION: Subgroups with a poorer prognosis exist among patients with human papillomavirus positive oropharyngeal squamous cell carcinoma (HPV-positive OPSCC). This study aims to identify histological and genetic differences within HPV-positive OPSCC and correlate these findings with patient outcomes. METHODS: The study included …
de, us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Maria Ziogas, Oliver Siefer, Nora Wuerdemann, Harini Balaji et autres
Head and Neck Squamous Cell Carcinoma (HNSCC), particularly Oropharyngeal Squamous Cell Carcinoma (OPSCC), is a major global health challenge due to its increasing incidence and high mortality rate. This study investigates the role of aldo-keto reductase 1C2 (AKR1C2) in OPSCC, focusing on …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Imke Demers, Harini Balaji, Harma Feitsma, Ellen Stelloo et autres
Human papillomavirus (HPV) infections are an increasing cause of oropharyngeal squamous cell carcinomas (OPSCC). Integration of the viral genome into the host genome is suggested to affect carcinogenesis, however, the correlation with OPSCC patient prognosis is still unclear. Research on HPV integration …
nl, de
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Charlotte Klasen, Nora Wuerdemann, Pauline Rothbart, Johanna Prinz et autres
BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in treatment response and prognosis. However, only limited data in OPSCC according to …
de
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Imke Demers, Harini Balaji, Harma Feitsma, Irinia Sergeeva et autres
Abstract Background: Human papillomavirus (HPV) infections are the principal cause of cervical cancers, subsets of anogenital and head and neck cancers (HNC). During persistent infection, viral DNA integration into the host genome may occur, which is suggested to affect carcinogenesis. One of …
nl, de
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Senem Uzun, Yüksel Korkmaz, Nora Wuerdemann, Christoph Arolt et autres
VEGF signaling regulated by the vascular endothelial growth factor receptor 2 (VEGFR2) plays a decisive role in tumor angiogenesis, initiation and progression in several tumors including HNSCC. However, the impact of HPV-status on the expression of VEGFR2 in OPSCC has not yet …
de, tr
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Harini Balaji, Imke Demers, Nora Wuerdemann, Julia Schrijnder et autres
A constantly increasing incidence in high-risk Human Papillomaviruses (HPV)s driven head and neck squamous cell carcinomas (HNSCC)s, especially of oropharyngeal origin, is being observed. During persistent infections, viral DNA integration into the host genome may occur. Studies are examining if the physical …
de, nl
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Nora Wuerdemann, Katharina Pütz, Hans Nikolaus Caspar Eckel, Rishabh Jain et autres
Tumor growth and survival requires a particularly effective immunosuppressant tumor microenvironment (TME) to escape destruction by the immune system. While immunosuppressive checkpoint markers like programmed cell death 1 ligand (PD-L1) are already being targeted in clinical practice, lymphocyte-activation-protein 3 (LAG-3), T-cell immunoglobulin …
de, nl
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Nora Wuerdemann, Sibel Elif Gültekin, Katharina Pütz, Claus Wittekindt et autres
Carcinogenesis of human papillomavirus (HPV)-related (+) oropharyngeal squamous cell carcinoma (OPSCC) differs from HPV-negative (–) OPSCC. HPV-related immune-escape-mechanism could be responsible for the development and progression of HPV+ tumors and an immunophenotype different from HPV– OPSCC is expected. The purpose of this …
de, tr, nl
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Lisa Pinatti, Heather M. Walline, Thomas E. Carey, Jens Peter Klußmann et autres
Infections with high-risk human papilloma viruses (HPV) are responsible for a significant number of oropharyngeal squamous cell carcinoma (OPSCC), with infection rates currently rising at epidemic rates in the western world. Synchronous bilateral HPV+ tumors of both tonsils are a very rare …
us, de
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Axel Lechner, Hans Schlößer, Martin Thelen, Kerstin Wennhold et autres
B lymphocytes are important players in immune responses to cancer. However, their composition and function in head and neck squamous cell carcinoma (HNSCC) has not been well described. Here, we analyzed B cell subsets in HNSCC (n = 38), non-cancerous mucosa (n …
de, ch, sg
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Christian U. Huebbers, Femke Verhees, Leonard Poluschkin, Nadine C. Olthof et autres
Different studies have shown that HPV16-positive OPSCC can be subdivided based on integration status (integrated, episomal and mixed forms). Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was …
de, nl, ca
(code pays fourni par la source)