Keiichi Otsuka

Significance of stem cell competition in the dose-rate effects

Masaru Tomita, Yuki FUJIMICHI, Keiichi Otsuka, M. Sasaki et autres

The system of radiological protection has been functioning well and is sufficiently robust.However, it needs to be further improved by new scientific findings.At low dose and low dose rate, which are the main areas of radiological protection, carcinogenesis is regarded as the …

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P3.01-97 Which is Better Prognostic Factor, PS, Inflammatory Marker, or PD-L1 Expression in Treating NSCLC with Nivolmab; A Retrospective Analysis

Akihiro Tamiya, Yoshihiko Taniguchi, Yuji Inagaki, Nagahiro Saijo et autres

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Gallstones were associated with the gastrointestinal adverse events of cinacalcet in hemodialysis patients with secondary hyperparathyroidism

Keiichi Otsuka, Yoichi Ohno, Joji Oshima

This study aimed to investigate the association of gastrointestinal (GI) adverse events of cinacalcet with gallstones in the hemodialysis (HD) patients with secondary hyperparathyroidism (SHPT). A total of 23 HD patients under the treatment with cinacalcet and 101 control patients were enrolled …

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Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)

Kazuyoshi Otake, Yuuichi Sakurai, Haruyuki Nishida, Hideo Fukui et autres

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The Clinical Study for Genetic Evaluation of α2B-AR Gene Polymorphism in Neurally Mediated Syncope

Tomoyoshi Komiyama, Takatsugu Hirokawa, Kyoko Sato, Akiko Oka et autres

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Terukazu Kawasaki (10 September 1936 - 13 May 2014).

Keiko Uezono, Keiichi Otsuka, P Cugini, Junichirô Kawasaki et autres

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Prediction of in-vivo pharmacokinetic profile for immediate and modified release oral dosage forms of furosemide using an in-vitro–in-silico–in-vivo approach

Keiichi Otsuka, Christian Wagner, Arzu Selen, Jennifer Dressman

OBJECTIVES: To develop a physiologically based pharmacokinetic (PBPK) model for furosemide immediate release (IR) tablets and modified release (MR) capsules by coupling biorelevant dissolution testing results with pharmacokinetic (PK) and physiologic parameters, and to investigate the key factors influencing furosemide absorption using …

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Mathematical model of cardiovascular disease risk based on Vascular Variability Disorders

Jarmila Siègelovà, Ladislav Dušek, Keiichi Otsuka, Germaine Cornélissen

Blood pressure (BP) values during ambulatory BP monitoring are mostly still interpreted conventionally in the light of the same fixed 24-hour, daytime and nighttime limits for all adults 18 years and older. We show that a chronobiologic approach taking into consideration the …

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Coupling biorelevant dissolution methods with physiologically based pharmacokinetic modelling to forecast in-vivo performance of solid oral dosage forms

Keiichi Otsuka, Yasushi Shono, Jennifer Dressman

OBJECTIVES: To summarize the basis for and progress with the development of in-vitro-in-silico-in-vivo (IV-IS-IV) relationships for oral dosage forms using physiologically based pharmacokinetic (PBPK) modelling, with the focus on predicting the performance of solid oral dosage forms in humans. KEY FINDINGS: Various …

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Oral administration of Bifidobacterium longum in a gastro-resistant seamless capsule decreases serum phosphate levels in patients receiving haemodialysis

Toshihisa Ogawa, Makoto K. Shimada, Nobuo Nagano, Kyoko Ito et autres

When kidney function decreases, phosphate (P) per se can initiate and promote hyperparathyroidism and vascular calcification. Therefore, hyperphosphataemia is a widely recognized risk factor for mortality and cardiovascular disease in patients with chronic kidney disease (CKD) [1]. Despite the introduction in the …

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Eating alone among community-dwelling Japanese elderly: Association with depression and food diversity

Yumi Kimura, Taizo Wada, Kiyohito Okumiya, Yasuko Ishimoto et autres

UNLABELLED: Eating alone is an emerging social concern these days along with the background of serious aging population growth and increasing number of single-dwellers in Japan. However, little study is focused eating alone and its relation to the health status of community-dwelling …

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Administration of an Angiotensin-Converting Enzyme Inhibitor Improves Vascular Function and Urinary Albumin Excretion in Low-Risk Essential Hypertensive Patients Receiving Anti-Hypertensive Treatment with Calcium Channel Blockers. Organ-Protecting Effects Independent of Anti-Hypertensive Effect

Yoshihiko Watanabe, Emiko Takasugi, Kazunobu Shitakura, Kiyotaka Okajima et autres

Concomitant administration of calcium channel blockers (CCBs) and angiotensin-converting enzyme inhibitors (ACEIs) to hypertensive patients at high risk for cardiovascular disease can prevent cardiovascular disease occurrence, but the effects of this treatment on renal and vascular function in low-risk hypertensive patients are …

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