Qinjie Tian

Practice guideline for the treatment and management of iatrogenic premature ovarian insufficiency

Xiangyan Ruan, Xu Che, Hefeng Huang, Chenghong Yin et autres

It is well known that premature ovarian insufficiency (POI) seriously affects the fertility, quality of life, and health of young women. A meta-analysis of global data indicated that the current population prevalence of POI is as high as 3.7 %, but exceeds …

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Molecular pathogenesis, diagnosis, and management challenges in complete androgen insensitivity syndrome

Chunqing Wang, Qinjie Tian

Complete androgen insensitivity syndrome (CAIS) is a rare X-linked recessive disorder of sex development (DSD) caused by androgen receptor (AR) gene mutation and present with female phenotypes with male chromosomal karyotype. Primitive bipotent gonads in CAIS differentiate into testes producing androgens and …

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Identification of a novel variant in MYRF gene in a patient with 46, XX disorders of sex development

Leilei Ding, Qinjie Tian

Objective To expand the clinical phenotype associated with MYRF mutations in disorders of sex development (DSDs).Methods We present a case of a 17-year-old patient with a female phenotype who presented with primary amenorrhea.Results The patient’s external genitalia was entirely female in appearance, …

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Multi-specialty Physician Preferences and Perceptions in Treatment and Management of Polycystic Ovary Syndrome in China: Survey and Discrete Choice Experiment

Zhuowei Gu, Wei Chen, Jian Ming, Haijiao Liu et autres

INTRODUCTION: Polycystic ovary syndrome (PCOS) is one of the most common gynecological endocrine diseases in reproductive-aged women. Given the multifaceted nature of PCOS and the involvement of multiple disciplines, the diagnosis and treatment of PCOS vary among different specialties. Our study aimed …

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Correction: Clinical Characteristics and Molecular Aetiology of Cytochrome P450 Oxidoreductase Deficiency Diagnosed in 46,XX Patients

Duoduo Zhang, Leilei Ding, Shan Deng, Qinjie Tian

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Unmet needs in the management of abnormal uterine bleeding: insights from social media listening

Marcelo Graziano Custódio, Hisham Arab, Andressa da Silva van der Laan, Н. Ю. Педаченко et autres

BACKGROUND: Abnormal uterine bleeding (AUB) impacts the quality of life of women globally. While international classifications and frameworks exist, there are still critical unmet needs in awareness, diagnosis, treatment, and patient support. To better understand these, the lived experiences of patients with …

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Clinical Characteristics and Molecular Aetiology of Cytochrome P450 Oxidoreductase Deficiency Diagnosed in 46,XX Patients

Duoduo Zhang, Shan Deng, Qinjie Tian

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The clinical diversity and molecular etiology in 46, XY disorders of sex development patients without uterus

Leilei Ding, Min Luo, Shan Deng, Duoduo Zhang et autres

BACKGROUND: Disorders of sexual development (DSDs) are a group of rare conditions with a discordance of chromosomal, gonadal, or phenotypic features of the internal and/or external genitalia, which accounts for 0.5% of the population. The precise diagnosis of 46, XY DSDs without …

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Therapeutic selection for abnormal uterine bleeding with ovulatory dysfunction: a cross-sectional study in Chinese women

Xiaoyue Zhao, Min Luo, Qinjie Tian

OBJECTIVE: To investigate the therapeutic selection of abnormal uterine bleeding with ovulatory dysfunction (AUB-O) among Chinese women and analyze the impact of various factors. METHODS: This was a cross-sectional study involving 3527 patients with AUB-O diagnosed by local doctor between 14 and …

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Use and knowledge of the two FIGO systems for nongestational abnormal uterine bleeding in the reproductive years: A multinational survey

Francisco J. Ruiloba, Ally Murji, Qinjie Tian, Sarah Maheux‐Lacroix et autres

OBJECTIVE: To evaluate the worldwide use of FIGO's two systems for the classification of causes and contributors to nongestational abnormal uterine bleeding in the reproductive years by obstetrics and gynecology professionals worldwide, to identify knowledge gaps, and explore barriers to implementation. METHODS: …

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Identification of novel variants and candidate genes in women with 46,XX complete gonadal dysgenesis

Leilei Ding, Shan Deng, Pan Zhang, Duoduo Zhang et autres

BACKGROUND: 46,XX complete gonadal dysgenesis (46,XX-CGD) is a rare disorder of sexual development (DSD) characterized by primary amenorrhea and a lack of spontaneous pubertal development in individuals with a 46,XX karyotype despite the presence of female internal and external genitalia due to …

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Unmet needs in abnormal uterine bleeding due to ovulatory dysfunction

Tommaso Simoncini, Hisham Arab, Н. Ю. Педаченко, Qinjie Tian et autres

Ovulatory disorders are a common cause of abnormal uterine bleeding in women of reproductive age. The International Federation of Gynecology and Obstetrics currently offers a causal classification system for ovulatory disorders but does not provide clear management recommendations. There remains regional disparity …

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