Santina A. Zanelli

Development and validation of the Prognostic Respiratory Intensity Scoring Metric (PRISM)

Madelyn G. Nance, Carrington S. Davis, Zoe G Kitchings, Chad Aldridge et autres

AIMS: Invasive respiratory interventions save infant lives, yet have negative consequences for their health and neurodevelopment. Here we present the Prognostic Respiratory Intensity Scoring Metric (PRISM) as an accurate, summative tool of respiratory support needs in hospitalized neonates well suited for predicting …

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Therapeutic Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy: Clinical Report

Santina A. Zanelli, Courtney J. Wusthoff, Ashley M. Lucke, David A. Kaufman et autres

Therapeutic hypothermia to a temperature of 33.5 to 34.5 °C initiated within 6 hours of birth and continued for 72 hours reduces the risk of death or moderate-to-severe neurodevelopmental impairments in neonates with moderate-to-severe hypoxic-ischemic encephalopathy (HIE) born at ≥36 0/7 weeks …

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Questions From NeoReviews: A Study Guide for Neonatal-Perinatal Medicine, Volume 2

Theodore De Beritto, Henry C. Lee, Dara D. Brodsky, Santina A. Zanelli

Elevate your expertise in neonatal-perinatal medicine and prepare confidently for the board certification examination with volume 2 of Questions From NeoReviews from the editors of NeoReviews, the online neonatology journal from the American Academy of Pediatrics. Available for purchase at https://www.aap.org/Questions-From-NeoReviews-A-Study-Guide-for-Neonatal-Perinatal-Medicine-Volume-2-Paperback

From Breath to Brain: NICU respiratory interventions and bedside brain signal entropy predict later autism risk

Madelyn G. Nance, Winnie Chang, Chad Aldridge, Jennifer C. Burnsed et autres

Premature infants often experience hypoxia and require prolonged ventilation, which can trigger systemic inflammation, damage the developing brain, and increase the risk of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Early intervention is key for ensuring optimal outcomes for those with …

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Reducing Golden Hour Admission Times for Extremely Preterm Infants: An Improvement Science Initiative

Nicholas M. Heitkamp, Hannah Fox, Megan R. Elliott, Jonathan R. Swanson et autres

Objective: The Golden Hour is the first 60 minutes of life for extremely preterm infants and represents a critical window where timely stabilization can reduce morbidity such as intraventricular hemorrhage and bronchopulmonary dysplasia. At the University of Virginia, average Golden Hour admission …

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Benefits and risks of therapeutic hypothermia for hypoxic-ischemic encephalopathy in late preterm infants

Mohamed El‐Dib, Dalal Abdelgadir, Kaashif Aqeeb Ahmad, Mariam Ayed et autres

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From Breath to Brain: NICU Respiratory Interventions and Bedside Brain Signal Entropy Predict Later Autism Risk

Madelyn G. Nance, Winnie Chang, Chad Aldridge, Jennifer C. Burnsed et autres

Premature infants often experience hypoxia and require prolonged ventilation, which can trigger systemic inflammation, damage the developing brain, and increase the risk of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Early intervention is key for ensuring optimal outcomes for those with …

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Increased parent speech and parent stress is associated with early vocalizations in preterm infants

Kelsey M. Sullivan, Meghan H. Puglia, Ashley Trinh, Mark R. Conaway et autres

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Impact of Parental Speech and Stress on Early Language Development in Preterm Infants

Kelsey M. Sullivan, Meghan H. Puglia, Ashley Trinh, Mark R. Conaway et autres

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Association of Parental Interactions and Therapies with Cerebral Oxygenation Variability in the Neonatal Intensive Care Unit

Presley Volkema, Lisa Letzkus, Michael C. Spaeder, Santina A. Zanelli

Objective This study evaluated the association of parental interactions and therapies with cerebral oxygenation (rScO2) and rScO2 variability in infants using near-infrared spectroscopy. Study Design Prospective pilot study in clinically stable infants admitted to the neonatal intensive care unit (NICU). Infants were …

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A randomized-controlled trial of parent-administered interventions to improve short-term motor outcomes in hospitalized very low birthweight infants

Lisa Letzkus, Mark R. Conaway, Richard F. Daugherty, Michelle A. Hook et autres

BACKGROUND: Premature infants are at increased risk for cerebral palsy (CP). Early interventions with a motor focus and administered by parents may improve motor outcomes. AIMS: Secondary study evaluating the short-term motor outcomes and risk for CP in very low birthweight (VLBW) …

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Machine learning approaches to evaluate infants’ general movements in the writhing stage—a pilot study

Lisa Letzkus, J. Vince Pulido, Abiodun Adeyemo, Stephen Baek et autres

The goals of this study are to describe machine learning techniques employing computer-vision movement algorithms to automatically evaluate infants' general movements (GMs) in the writhing stage. This is a retrospective study of infants admitted 07/2019 to 11/2021 to a level IV neonatal …

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