Association of Parental Interactions and Therapies with Cerebral Oxygenation Variability in the Neonatal Intensive Care Unit

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Objective This study evaluated the association of parental interactions and therapies with cerebral oxygenation (rScO2) and rScO2 variability in infants using near-infrared spectroscopy. Study Design Prospective pilot study in clinically stable infants admitted to the neonatal intensive care unit (NICU). Infants were monitored continuously for 48 hours, and rScO2 during parental interactions and therapies was compared with periods of no activity. rScO2 variability was derived using the root mean of successive squared differences of averaged 1-minute rScO2 values. Wilcoxon matched-pairs signed-rank test was used to compare baseline and activity periods. Results Data analysis included 23 infants. rScO2 variability increased during periods of parental interaction (p = 0.04) and during combined parental interaction and therapies (p = 0.04). Conclusion We observed that routine NICU interventions are associated with increased rScO2 variability in clinically stable NICU patients. rScO2 variability may represent a useful biomarker for the early determination of the safety and efficacy of NICU interventions. Key Points

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.