Hunter G. Lindsay

NFAT mediates pro-tumorigenic inflammation in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Chuner Guo, Michelle F. Griffin, Annah Grace Morgan, Deshka S. Foster et autres

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma, low immunogenicity, and resistance to therapy. Cancer-associated fibroblasts (CAFs) are key stromal cells within the tumor microenvironment (TME) that drive tumor progression. Interleukin-1 (IL-1) promotes fibrosis, pathogenic inflammation, and poor prognosis in …

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Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells

Abigail Cheever, Hunter G. Lindsay, Chloe Kang, Mackenzie Hansen et autres

Introduction: Chimeric antigen receptor (CAR) T cells have recently become an important treatment for hematological cancers by efficiently eliminating B cells. B cell depleting CAR T cells are also in clinical trials for their use in treating severe autoimmune diseases and have …

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Abstract 54: Engineering chimeric antigen receptor (CAR) T cells using autoantigen binding domains for treatment of B cell malignancies with increased specificity

Abiagil Cheever, Hunter G. Lindsay, Mackenzie Hansen, Chloe Kang et autres

Abstract Introduction: Chronic inflammation often leads to cancer, and many autoimmune diseases lead to a significantly increased risk of developing cancer. Though many autoimmune diseases, like Graves’ Disease (GD), don’t have treatments that address this risk. Chimeric antigen receptor (CAR) T cells …

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The Role of Atypical Chemokine Receptors in Neuroinflammation and Neurodegenerative Disorders

Hunter G. Lindsay, Colby J. Hendrix, Josue D. Gonzalez Murcia, Christopher Haynie et autres

Neuroinflammation is associated with several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Neuroinflammation provides protection in acute situations but results in significant damage to the nervous system if chronic. Overexpression of chemokines within the brain results …

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Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin

Deshka S. Foster, Michael Januszyk, Daniel Delitto, Kathryn E. Yost et autres

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Effectiveness of light therapy on superficial healing following cupping induced ecchymosis: A pilot project

Hunter G. Lindsay

Introduction: The idea of using light therapy to heal musculoskeletal, dermatological, and psychological pathologies is still a concept that is emerging in the medical field. Previous research suggests that light therapy will enhance blood flow, decrease pain, and facilitate the injury recovery …