Ji‐Jun Chen

Artemisiyneolides A–K, Guaiane Sesquiterpenoid-Heptatriyne Hybrids through C–C Linkages from Artemisia sieversiana with Antihepatoma Activity

Yan-Mei Weng, Tian-Ze Li, Yun‐Bao Ma, Hao-Wei Zhang et autres

Artemisiyneolides A-K (1-11), guaiane sesquiterpenoid-heptatriyne hybrids, were isolated from Artemisia sieversiana (Asteraceae). Their structures were elucidated using NMR, HRESIMS, ECD calculations, and X-ray diffraction analysis. Compounds 1-11 featured 5/5/7/5-fused ring frameworks bearing a 1,3,5-heptatriyne side chain by C-C linkages, which were biosynthetically …

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Disparity in Mpox awareness and vaccine hesitancy: a cross-sectional study of 3,483 university students in Northwest China

Ying Zhang, Jun Gan, Dong Miao, Xiao Yue Li et autres

Background Mpox has shown a westward spreading trend in China and university students are a high-risk group. This study aimed to assess the current status of Mpox-related knowledge, attitudes, vaccination willingness, and associated factors among college students in northwestern China, so as …

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Deep learning facilitated discovery of prognosis biomarkers and their ligands to improve liver cancer treatment

Yongcui Wang, Tian-Ze Li, Sheng-Zhen Li, Qi-Hao Li et autres

BACKGROUND: Multi-kinase and immune checkpoint inhibitors have been developed for the treatment of hepatocellular carcinoma (HCC). However, the improvement in cancer survival remains limited due to their similar structures and targets. It is very interesting to identify novel prognosis biomarkers and corresponding …

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A new target for the treatment of oral squamous cell carcinoma: Circ_0046336

Ji‐Jun Chen, Liang Wang, Danhua Ma, Hongyan Gao et autres

Background This study was designed to investigate the mechanism of Circ_0046336 in oral squamous cell carcinoma (OSCC). Methods The expression pattern of Circ_0046336 and its distribution in OSCC cell lines (SCC-9 and CAL-27) were identified. Fluorescence in situ hybridization was applied to …

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Knowledge, attitude and practice towards oral health in parents and teachers of kindergarten students: a cross-sectional survey

Hongyan Gao, Ji‐Jun Chen, Yuyuan Shi, Danhua Ma et autres

OBJECTIVES: This study aimed to explore the relationship between oral health and the knowledge, attitudes and practices (KAP) of parents and teachers of kindergarten students towards oral health. DESIGN: This web-based cross-sectional survey was conducted in Ningbo City from February 2023 to …

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Artemiyrianins A-H, guaiane-type sesquiterpenoids from Artemisia myriantha var. pleiocephala and their antihepatoma activity

Mengfei Wang, Tianze Li, Yun‐Bao Ma, Feng‐Jiao Li et autres

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Drought management for long-term water sustainability and resilience

Shan‐e‐hyder Soomro, Muhammad Waseem Boota, Jiali Guo, Yinghai Li et autres

Context The global water crisis is driven by human overconsumption, depleting resources faster than they can regenerate. This threatens ecosystems and exacerbates drought-related water shortages, which may escalate into international conflicts if not properly managed. Aims This study assesses the effectiveness of …

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A new species of Gracixalus (Amphibia, Anura, Rhacophoridae) from Guizhou Province, China

Jing Liu, Caichun Peng, Bin Wang, Chao-Bo Feng et autres

A new species of small tree frog was discovered in southwestern China, exhibiting morphological differences and molecular divergence. The new species, formally described herein as Gracixalus weiisp. nov., is morphologically distinct from other congeners by body size (SVL 30.1–34.0 mm in males …

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Artemisieverolides A—G, Sesquiterpenoid Trimers from Artemisia sieversiana and Their Antihepatic Fibrosis Activity

Yan‐Mei Weng, Tian‐Ze Li, Xiaoyan Huang, Qi‐Hao Li et autres

Comprehensive Summary Artemisieverolides A—G (1—7), seven unreported sesquiterpenoid trimers, were isolated from Artemisia sieversiana (Asteraceae), and elucidated by comprehensive spectral data and electronic circular dichroism (ECD) calculations. Compounds 1, 2, 4 and 6 were unambiguously determined by the single‐crystal X‐ray diffraction. Artemisieverolide …

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Artemyriantholidimers A-G, undescribed guaiane-type sesquiterpenoid dimers from Artemisia myriantha and their antihepatoma activities

Mengfei Wang, Tian-Ze Li, Yun‐Bao Ma, Yongcui Wang et autres

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Artemselenoids A–H, eight guaiane-type sesquiterpenoid dimers from Artemisia selengensis and their antihepatoma activities

Rong‐Fu Chen, Tianze Li, Yun‐Bao Ma, Yongcui Wang et autres

Artemselenoid A (1), a rare [2 + 2]-type guaiane sesquiterpenoid dimer (GSD), and 7 new GSDs (2–8) were isolated from Artemisia selengensis ; compounds 3 and 8 demonstrated marked antihepatoma activities.

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Artemdubins A–E from Artemisia dubia var. subdigitata : antihepatoma activity, molecular docking and molecular dynamics studies

Kexin Yang, Tianze Li, Yun‐Bao Ma, Yongcui Wang et autres

Network pharmacological, molecular docking, molecular dynamics, ECD, DP4+ analyses, and antihepatoma activity studies of different types of sesquiterpenoids were carried out.

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