Karen D. Godette

Lung Dose and Pneumonitis Risk Following Five‐Fraction Breast Radiotherapy

Kristin Ward, Matthew J. Case, Matthew Thomas, Sheela Hanasoge et autres

PURPOSE: To evaluate associations between lung dose and symptomatic pneumonitis in five-fraction breast radiotherapy and identify strategies to limit lung exposure. METHODS AND MATERIALS: We retrospectively analysed 224 consecutive patients with early-stage breast cancer treated between 2020 and 2024 at a single …

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Utilization, Cost, and Subsequent Salvage Treatment of Ablative Therapies for Localized Prostate Cancer in the United States

Nikhil Sebastian, Dattatraya Patil, Pretesh R. Patel, Ashesh B. Jani et autres

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Interim Analysis of a Phase 2 Single Arm Trial of Extended Lymph Node Proton Irradiation for High Risk Prostate Cancer

Priyanka Patel, Vishal R. Dhere, N. Sebastian, Sagar A. Patel et autres

Utilization, health care expenditures, and patient costs of definitive treatment modalities for localized prostate cancer in the United States

Nikhil Sebastian, Dattatraya Patil, Pretesh Patel, Ashesh B. Jani et autres

BACKGROUND: Radical prostatectomy (RP) and radiotherapy (RT) are standard-of-care treatments for localized prostate cancer. The authors studied the utilization and total health care and patient-incurred costs of RP and RT in the United States using the Merative MarketScan Medicare (Medicare Supplemental and …

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Utilization, healthcare expenditures, and patient costs of definitive treatment modalities for localized prostate cancer in the United States.

Nikhil Sebastian, Dattatraya Patil, Pretesh Patel, Ashesh B. Jani et autres

370 Background: Radical prostatectomy (RP) and radiotherapy are standard-of-care treatments for localized prostate cancer. We studied the contemporary trends in utilization and costs of prostatectomy and radiotherapeutic modalities in the U.S. Methods: We analyzed the MarketScan Medicare Supplemental and Coordination of Benefits …

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ctDNA Predicts Pain Response in a Multi-Institutional Phase II Trial of Palliative Radiation, Palbociclib and Hormone Therapy in Metastatic Breast Cancer

M. Torres, Sarah Friend, A. Niemierko, J.Y. Lin et autres

Intraoperative radiation therapy for early‐stage breast cancer

Lara Schwieger, Jeffrey M. Switchenko, Yichun Cao, Isabella Amaniera et autres

BACKGROUND: Intraoperative radiotherapy (IORT) offers more convenience compared to external beam radiotherapy (EBRT) following breast-conserving surgery for early-stage breast cancer. This study describes the implementation of IORT at a metropolitan academic cancer center. METHODS: Demographics, tumor characteristics, margin status, adjunct EBRT, and …

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Impact of Rectal Spacer on Toxicity Reduction in Men Treated With Proton Versus Photon Therapy

Vishal R. Dhere, Jun Zhou, Nikhil Sebastian, Ashish B. Patel et autres

Rectal toxicity after prostate cancer (PCa) radiotherapy may be greater with protons compared with photon intensity modulated radiotherapy (IMRT), perhaps due to lateral penumbra and end-of-range uncertainty. Rectal spacers (RS) have been shown to mitigate RT-associated acute/late rectal toxicity in men treated …

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Validation of Patient-Reported Outcomes in Patients With Nonmetastatic Breast Cancer Receiving Comprehensive Nodal Irradiation in the RadComp Trial

Elizabeth A. Hahn, Stephanie L. Pugh, Hien L. Lu, Alyssa Vela et autres

PURPOSE: Our purpose was to evaluate the measurement properties of patient-reported outcome (PRO) measures used in the ongoing RadComp pragmatic randomized clinical trial (PRCT). METHODS AND MATERIALS: The deidentified and blinded data set included 774 English-speaking female participants who completed their 6-month …

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Abstract PO4-27-08: A Phase II Multi-Institutional Study of Concurrent Radiotherapy, Palbociclib, and HormoneTherapy for Treatment of Bone Metastasis in Breast Cancer Patients

Mylin A. Torres, Jolinta Lin, Sarah Friend, Canhua Xiao et autres

Abstract Background: This Phase II study aimed to determine the efficacy and safety of administering palliative radiotherapy (RT) to bone metastases (mets) in patients (pts) receiving concurrent palbociclib and hormone therapy (HT) for hormone receptor positive, Her2/neu negative breast cancer. The primary …

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Impact of androgen deprivation therapy in patients with unfavorable intermediate-risk prostate cancer receiving brachytherapy-based dose-escalated radiation therapy

Nikhil Sebastian, Subir Goyal, Yuan Liu, Vishal R. Dhere et autres

Purpose: While the benefit of short-term androgen deprivation therapy (ADT) has been established for patients with intermediate-risk (IR) prostate cancer (PCa) receiving dose-escalated external beam radiation therapy (EBRT), the role of ADT for patients treated with brachytherapy (BT) with or without supplemental …

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Association of Radiation Facility Volume with Overall Survival in Patients with Very High-Risk Prostate Cancer Treated with Radiation and Androgen Deprivation Therapy

N. Sebastian, Sharad Goyal, Yuan Liu, Payal R. Patel et autres

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