Vishal R. Dhere

18 F-Fluciclovine or 68 Ga-PSMA-11 PET/CT–guided Salvage Radiotherapy Changes in Postprostatectomy Biochemical Recurrence: Secondary Analysis of the EMPIRE-2 Trial

Olayinka A. Abiodun-Ojo, A. Jani, Subir Goyal, Ismaheel O. Lawal et autres

Molecular imaging with 18 F-fluciclovine or 68 Ga–prostate-specific membrane antigen–11 had a substantial effect on PET/CT-guided salvage radiotherapy planning in participants with prostate cancer recurrence after prostatectomy.

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Utilization, Cost, and Subsequent Salvage Treatment of Ablative Therapies for Localized Prostate Cancer in the United States

Nikhil Sebastian, Dattatraya Patil, Pretesh R. Patel, Ashesh B. Jani et autres

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Association of a post-prostatectomy digital pathology–based multimodal artificial intelligence (MMAI) biomarker with nodal and extrapelvic metastasis on PET/CT at the time of biochemical recurrence and event-free survival following salvage radiotherapy.

Sagar Anil Patel, Nikhil Sebastian, Vishal R. Dhere, David M. Schuster et autres

378 Background: Clinical prostate cancer variables have limited ability to predict patterns of recurrence or outcomes after radical prostatectomy (RP). In this analysis, we evaluated the performance of a digital pathology multimodal artificial intelligence (MMAI) algorithm in predicting patterns of recurrence at …

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Genomic risk classifier performance in PET-guided post-prostatectomy patients: Secondary analysis of a randomized trial.

Vishal R. Dhere, David M. Schuster, Subir Goyal, Eduard Schreibmann et autres

386 Background: Genomic risk assessment with genomic classifiers (GC) have enhanced risk stratification in post-prostatectomy patients, however, validation studies have relied on conventional imaging workup to guide secondary radiation treatment (SRT). Our hypothesis is that GC will remain prognostic in a population …

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511 Digital Pathology Based Multimodal Artificial Intelligence Scoring in Radical Prostatectomy (Treatment Naive Prostate Cancers) Predicts Likelihood of Nodal Metastasis and Correlates with Higher Tumor Quantitation and Aggressive Histologic Features

Lalit Patel, Vishal R. Dhere, Danielle Croucher, Yi Ren et autres

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Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer

Sagar A. Patel, Adithya Yadalam, Marly van Assen, Stephanie Cantu et autres

Importance: Androgen deprivation therapy (ADT) for men with prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies have yielded conflicting results regarding the CV safety of gonadotropin-releasing hormone (GnRH) agonists vs antagonists. Objective: To …

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[18F]-Fluciclovine or [68Ga]-PSMA-11 Molecular Imaging To Guide Dose Escalation of Salvage Radiotherapy After Radical Prostatectomy for Prostate Cancer: The EMPIRE-2 Trial

Ashesh B. Jani, Vishal R. Dhere, Subir Goyal, Eduard Schreibmann et autres

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Abstract 4352126: Accelerated Coronary Atherosclerosis Following Relugolix Versus Leuprolide Androgen Deprivation Therapy in Men with Prostate Cancer (REVELUTION): An Open-Label Randomized Controlled Trial

Sagar Patel, Adithya Yadalam, Marly van Assen, Stephanie Cantu et autres

Purpose: Androgen deprivation therapy (ADT) for prostate cancer (PCa) is associated with cardiovascular (CV) morbidity, yet the biological basis remains unclear. Recent studies have yielded conflicting results regarding the CV safety of gonadotropin releasing hormone (GnRH) agonists versus antagonists. Re lugolix Ve …

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Abstract 4347552: Statin Use Mitigates Androgen Deprivation Therapy-Associated Coronary Atherosclerosis in Prostate Cancer: A Secondary Analysis of the REVELUTION Randomized Clinical Trial

Adithya Yadalam, Chang Liu, Marly van Assen, Carlotta Onnis et autres

Introduction: Prostate cancer (PCa) is the most common cancer in men. Androgen deprivation therapy (ADT) is the primary systemic therapy for PCa, with over 500,000 men in the US being treated with ADT each year. Despite the most widely utilized form of …

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MRI-guided neurovascular bundle avoidance in high dose rate prostate brachytherapy

Drew G. Gerber, Sean Dresser, Xiaofeng Yang, Richard L. J. Qiu et autres

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Knowledge‐based plan library‐guided adaptive proton stereotactic ablative radiotherapy (SABR) for localized prostate cancer

Keyur D Shah, Chih‐Wei Chang, Duncan Bohannon, Hamilton S. McGinnis et autres

BACKGROUND: Ultrahypofractionated proton stereotactic ablative radiotherapy (SABR) is an emerging treatment for localized prostate cancer (PCa), with efforts ongoing to further condense treatment regimens to fewer than five fractions. However, proton SABR is highly susceptible to interfractional anatomical variations due to its …

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The effect of interfractional variation on delivered dose with ultrahypofractionated pencil beam scanning proton therapy for localized prostate cancer

Keyur D Shah, Duncan Bohannon, Sagar A. Patel, Chih‐Wei Chang et autres

Abstract Purpose/objectives Proton stereotactic body radiotherapy (SBRT) using the pencil beam scanning (PBS) technique is increasingly used for localized prostate cancer (PCa) due to its potential for superior normal tissue sparing. However, interfractional anatomical variations pose challenges for accurate dose delivery, especially …

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