N. Sebastian

Patient-reported experiences of gynecologic cancer risk management in Lynch syndrome: A scoping review

Arabella Helgason, N de Silva, Jennifer Ellis-White, N. Sebastian et autres

Lynch syndrome (LS) is an inherited cancer predisposition syndrome associated with increased lifetime risks of endometrial, ovarian, colorectal, and other cancers. For individuals with LS who are at risk of gynecologic cancers, risk management may include gynecologic surveillance, symptom awareness, referral to …

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Data from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Abstract Endometrial cancer incidence continues to increase globally, driven mainly by obesity. Current diagnostic pathways rely on symptom presentation; no validated approach exists to identify asymptomatic individuals who may benefit from targeted prevention. The progesterone challenge test (PCT) is a physiologic assessment …

Supplementary Table S2 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S2 contains the Progesterone Challenge Test (PCT) daily questionnaire. Participants completed a daily questionnaire during the PCT to assess adherence, bleeding patterns, and side effects. The survey included binary response items on progestin intake, abnormal vaginal bleeding, and presence of …

Supplementary Table S3 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S3 shows the Large Language Model prompts used for qualitative analysis of exit survey responses. Prompts were developed to guide the use of a large language model (ChatGPT o4-mini and o4-mini-high) for qualitative analysis of de-identified free-text responses from participants …

Supplementary Table S8 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S8 contains symptom categories reflecting free-text responses provided by participants during the 24-day monitoring period of the PCT, which included the duration of MPA administration and follow-up. Responses were thematically coded into eight categories based on content analysis. Values represent …

Supplementary Table S5 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S5 contains complete demographic and clinical characteristics of study participants stratified by response to the progesterone challenge test (PCT), with groupings into PCT-positive (N = 16) and PCT-negative (N = 37). Variables include anthropometric measures, reproductive history, hormonal exposures, medical …

Supplementary Table S10 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S10 contains participant comments that were thematically analyzed to assess acceptability of the PCT, using the constructs of the Theoretical Framework of Acceptability (TFA). Quotes were drawn from free-text responses provided in post-PCT exit surveys. Themes reflect participant perspectives on …

Supplementary Table S9 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S9 is a summary of the number and proportion of participants who reported each listed adverse effect during the PCT. For each symptom, the table includes the median number of days the symptom was reported with interquartile range (IQR), the …

Supplementary Table S4 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S4 indicates the representativeness of the study population in the context of endometrial cancer, including sex, age, race/ethnicity, geography, and other equity-related considerations.

Supplementary Table S7 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S7 summarizes participant-reported reasons for declining enrolment following the study information call, categorized into logistical barriers, physician-related concerns, trial procedure considerations, medication-related concerns, and other reasons. The number of participants reporting each category is shown, with representative details provided for …

Supplementary Table S1 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S1 lists the medical conditions considered contraindications to progesterone or progestin use as manadated by Health Canada. Participants were excluded from undergoing the Progesterone Challenge Test (PCT) if they had a personal history of any of the listed conditions.

Supplementary Table S6 from The Progesterone Challenge Test as a Functional Biomarker of Endometrial Cancer Risk: Results from a Prospective Feasibility Study

Andrea Neilson, Rachel Woima, Dollina Dodani, Arabella Helgason et autres

Supplementary Table S6 compares demographic, clinical, and behavioral characteristics of participants who completed the Progesterone Challenge Test (PCT) with those who consented but did not complete the test. The analysis assesses potential selection or attrition bias. Continuous variables are reported as mean …