Minh T. N. Le

Unlocking extracellular vesicle-mediated efficient DNA delivery for long-lasting transgene expression

Melissa Tan, Yumi Kawamura, Carol Wang, Ryan Schneider et autres

Achieving efficient DNA delivery for sustained transgene expression while minimizing immune response remains a significant challenge in gene therapy. Here, we conduct an in-depth characterization of red blood cell-derived extracellular vesicles (RBCEVs) and evaluate their potential as DNA delivery vehicles targeting specific …

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Extracellular vesicle-delivered siRNA targeting RCN1 suppresses acute myeloid leukemia through TFAM-dependent mtDNA-cGAS-STING signaling

Huan Chen, Na An, Linlin Yang, Jin Lou et autres

Aim: Acute myeloid leukemia (AML) remains a highly aggressive hematologic malignancy with limited therapeutic options. This study aimed to elucidate how reticulocalbin-1 (RCN1) regulates mitochondrial DNA (mtDNA)-mediated innate immune signaling in AML and to evaluate the therapeutic potential of extracellular vesicle (EV)-mediated …

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Antimicrobial Stewardship Program in a Low-Middle Income Country: Impact of an Antibiotic Guideline for Neonatal Early-Onset Sepsis

Minh T. N. Le, Anh T. Do, H. Pham, Cuc T. Nguyen et autres

Background/Objectives: Initiation of empiric antibiotic therapy for neonatal early-onset sepsis (EOS) is prudent to prevent morbidity and mortality, particularly in low- and middle-income countries (LMICs). Inappropriate or prolonged antibiotic exposure in neonates is associated with poor clinical outcomes. Antimicrobial stewardship programs (ASPs) …

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A self-amplifying RNA vector based on rubella virus for mRNA therapeutics and vaccine applications

Miao Jing, Michelle Cheok Yien Law, Cao Dai Phung, Yu He et autres

Significant efforts have been made in the burgeoning field of RNA therapies since the COVID-19 pandemic. Self-amplifying RNA (saRNA)-based therapies are considered more promising than conventional messenger RNA due to their lower concentration requirements, long-lasting effects, and self-adjuvanticity. Here, we developed a …

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Designing nucleic acid-based therapeutics for cancer treatment: Updates on the state of the art

Boya Peng, Migara Kavishka Jayasinghe, Anh Hong Le, Nhut Minh Tran et autres

As in art, the ability of nucleic acids to be designed and synthesized as a novel treatment modality is limited only by the imagination. Nucleic acids of virtually all sizes and forms can be synthesized on demand, from short antisense oligonucleotides to …

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Safety and efficacy of KRAS antisense oligonucleotides and RIG-I agonists delivered by extracellular vesicles for pancreatic cancer peritoneal metastasis treatment

Xuan Dang, Cao Dai Phung, Lan Thi Ngoc Tran, Phuoc Trong Nguyen et autres

Pancreatic ductal adenocarcinoma (PDAC) often metastasizes to the peritoneum and is highly resistant to treatments due to its immunosuppressive microenvironment. In this study, we evaluate the safety and efficacy of a novel therapeutic strategy that combines KRAS-targeting antisense oligonucleotides (ASOs) with immunomodulatory …

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Extracellular Vesicles Administered via Intrathecal Injection Mediate Safe Delivery of Nucleic Acids to the Central Nervous System for Gene Therapy

Brenda Wan Shing Lam, Melissa Tan, Chang Gao, Thach Tuan Pham et autres

Gene therapy holds great potential for treating neurological disorders, but its implementation is limited by the challenge of developing a safe and effective delivery method to the central nervous system (CNS). Red blood cell-derived extracellular vesicles (RBCEVs) have the potential to address …

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Combination of KRAS ASO and RIG-I agonist in extracellular vesicles transforms the tumor microenvironment towards effective treatment of KRAS-dependent cancers

Cao Dai Phung, Trinh T. T. Tran, Brendon Zhi Jie Yeo, Rebecca Carissa Prajogo et autres

Rationale: Mutations in the KRAS gene drive many cancers, yet targeting KRAS mutants remains a challenge.Here, we address this hurdle by utilizing a nucleic acid-based therapeutic strategy delivered via extracellular vesicles (EVs) to simultaneously inhibit KRAS mutants and activate the RIG-I pathway, …

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A Metabolism‐Oriented Strategy to Directly Generate Photosensitizer‐Engineered Extracellular Vesicles from Cancer Cells

Dandan Wang, Xingang Liu, Xianming Zhang, Thach Tuan Pham et autres

Extracellular vesicles (EVs) hold great potential for delivering cancer therapy drugs. However, limited efficiency and sophisticated drug encapsulation procedures have hindered their effectiveness. Herein, β-D-glucose is modified with the synthesized photosensitizer (1-(4-carboxybutyl)-4-(7-(4-(diphenylamino)phenyl)benzo[c][1,2,5] thiadiazol-4-yl)pyridin-1-ium, named TB) via amide bond to form a glucose-conjugated …

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Reproducibility of extracellular vesicle research

Rossella Crescitelli, Juan Manuel Falcón‐Pérez, An Hendrix, Metka Lenassi et autres

Reproducibility of

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Towards Explainable Polypharmacy Risk Warnings Using Reinforcement Learning on Knowledge Graphs

Minh T. N. Le, Huy-Son Nguyen, Cam-Van Thi Nguyen, Duc-Trong Le et autres

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Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts

Ka Wai Wong, Yingying Zeng, Jia Hao Jackie Teo, Nadia Omega Cipta et autres

Embryonic stem cells possess the remarkable ability to self-organize into blastocyst-like structures upon induction. These stem cell-based embryo models serve as invaluable platforms for studying embryogenesis and therapeutic developments. Nevertheless, the specific intrinsic regulators that govern this potential for blastoid formation remain …

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