Srini V. Kaveri

Impact of heme on the therapeutic efficacy of anti-CD20 antibodies

Annaelle Marey-Jarossay, Alexia Tavares, Robin V. Lacombe, Hélène Delcourt et autres

Polyreactivity, the capacity of antibodies to recognize unrelated antigens, is often an undesirable trait in therapeutic antibodies, as it can impair pharmacokinetics and elevate the risk of adverse effects. A growing body of evidence indicates that antibodies can acquire polyreactivity and autoreactivity …

fr (code pays fourni par la source)

Influence of homocysteine on regulating immunothrombosis: mechanisms and therapeutic potential in management of infections

Aswathy S Nair, Lucio Tauro, Arnab Makhal, Teddy Sobczak et autres

Mechanisms controlling innate immune responses and coagulation are interdependent, evolutionarily entangled and make a complex network to form immuno-thrombosis axis which is an integral part of host-defence response. During infections, immunothrombosis generates intravascular scaffold enabling recognition, trap and destruction of pathogens facilitating …

in, fr (code pays fourni par la source)

Regulation of immune cell metabolism by therapeutic normal IgG intravenous immunoglobulin

Naresh Rambabu, Fawaz Alzaïd, Boban D Anđelković, Sruthi Vijaya Retnakumar et autres

BACKGROUND: Immune cell metabolism and metabolic end products influence the nature and magnitude of immune responses. Various autoimmune and inflammatory diseases are associated with dysregulated cellular metabolism. Intravenous immunoglobulin (IVIG), a therapeutic pooled normal IgG, is extensively used for the immunotherapy of …

fr, rs, ch (code pays fourni par la source)

Restoring immune tolerance in pemphigus vulgaris

A. Razzaque Ahmed, Mikole Kalesinskas, Srini V. Kaveri

Intravenous immunoglobulin (IVIg), a preparation of polyclonal serum IgG pooled from numerous blood donors, has been used for nearly three decades and is proving to be an efficient treatment for many autoimmune blistering diseases, including pemphigus vulgaris (PV). Despite its widespread use …

us, fr (code pays fourni par la source)

Intravenous Immunoglobulin: Mechanism of Action in Autoimmune and Inflammatory Conditions

Jagadeesh Bayry, Eisha Ahmed, Diana Toscano-Rivero, Nicholas Vonniessen et autres

fr, in, ca (code pays fourni par la source)

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

Cyril Planchais, Rémi Noé, Marie Gilbert, Maxime Lecerf et autres

Intravascular hemolysis occurs in diverse pathological conditions. Extracellular hemoglobin and heme have strong pro-oxidative and pro-inflammatory potentials that can contribute to the pathology of hemolytic diseases. However, many of the effects of extracellular hemoglobin and heme in hemolytic diseases are still not …

fr (code pays fourni par la source)

Systems biology and artificial intelligence analysis highlights the pleiotropic effect of IVIg therapy in autoimmune diseases with a predominant role on B cells and complement system

Cristina Segú-Vergés, Silvia Caño, Elisabeth Calderón‐Gómez, Helena Bartra et autres

Intravenous immunoglobulin (IVIg) is used as treatment for several autoimmune and inflammatory conditions, but its specific mechanisms are not fully understood. Herein, we aimed to evaluate, using systems biology and artificial intelligence techniques, the differences in the pathophysiological pathways of autoimmune and …

es, fr (code pays fourni par la source)

Boolean analysis of the transcriptomic data to identify novel biomarkers of IVIG response

Naresh Rambabu, Mano Joseph Mathew, Srini V. Kaveri, Jagadeesh Bayry

fr, in (code pays fourni par la source)

Vaccine‐induced immune thrombotic thrombocytopenia: Consider IVIG batch in the treatment

Anupama Karnam, Sébastien Lacroix‐Desmazes, Srini V. Kaveri, Jagadeesh Bayry

fr, in (code pays fourni par la source)

Antibody Therapy: From Diphtheria to Cancer, COVID-19, and Beyond

Deepak Kumar, Sulgey Gauthami, Jagadeesh Bayry, Srini V. Kaveri et autres

The dawn of the 20th century saw the formative years of developments in immunology. In particular, immunochemistry, specifically pertaining to antibodies, was extensively studied. These studies laid the foundations for employing antibodies in a variety of ways. Not surprisingly, antibodies have been …

in, fr, Maroc (code pays fourni par la source)

Impact of Autoantibodies to Complement Components on the Disease Activity in SLE.

Vandana Pradhan, Prasad V Khadilkar, Milind Nadkar, Seema Kini et autres

INTRODUCTION: Systemic Lupus Erythematosus (SLE) is a chronic multi-system autoimmune disease with varied clinical presentations. Complement components are the major players in disease pathogenesis. This retrospective cross-sectional study was aimed at assessing the role of autoantibodies to these complement components and their …

gb, hr, in, fr (code pays fourni par la source)

How IvIg Can Mitigate Covid-19 Disease: A Symmetrical Immune Network Model

Heinz Köhler, Srini V. Kaveri

In this report we provide a hypothesis of how intravenous immunoglobulin (IvIg) (pooled therapeutic normal IgG) mitigates the severe disease after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. The disease is caused by an overreaction of the innate immune …

us, fr (code pays fourni par la source)