Alessia Portante

DNAR-08. BASE EXCISION REPAIR AS A THERAPEUTIC TARGET FOR DIFFUSE HEMISPHERIC GLIOMA, H3.3G34-MUTANT

Alessia Portante, Laura Canty, Palak Patel, Sanja Pajovic et autres

Abstract Diffuse hemispheric gliomas with H3.3G34R/V mutations are primarily found in the cerebral hemisphere in adolescents and young adults, with a median age of 16-19 years. H3.3G34R frequently co-occurs with mutations in ATRX and TP53 as well as PDGFRα. We performed mutational …

ca (code pays fourni par la source)

Oncohistone interactome profiling uncovers contrasting oncogenic mechanisms and identifies potential therapeutic targets in high grade glioma

Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos et autres

Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations lead to local losses of H3K36me3 through …

ca, fr, gb (code pays fourni par la source)

Integrating morphologic and molecular histopathological features through whole slide image registration and deep learning

Kevin Faust, Michael Kyung Ik Lee, Anglin Dent, Clare Fiala et autres

BACKGROUND: Modern molecular pathology workflows in neuro-oncology heavily rely on the integration of morphologic and immunohistochemical patterns for analysis, classification, and prognostication. However, despite the recent emergence of digital pathology platforms and artificial intelligence-driven computational image analysis tools, automating the integration of …

ca, sa (code pays fourni par la source)

EPCO-16. ONCOHISTONE INTERACTOME PROFILING UNCOVERS MECHANISMS OF CHROMATIN DISRUPTION AND IDENTIFIES POTENTIAL THERAPEUTIC TARGETS IN PEDIATRIC HIGH-GRADE GLIOMA

Robert Siddaway, Laura Canty, Sanja Pajovic, Étienne Coyaud et autres

Abstract Mutations in histone H3 at amino acids 27 (H3K27M) and 34 (H3G34R) occur with high-frequency in pediatric high-grade glioma. H3K27M mutations have been shown to lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition with accompanying gains in H3K36me3, …

ca (code pays fourni par la source)

Publisher Correction: Intelligent feature engineering and ontological mapping of brain tumour histomorphologies by deep learning

Kevin Faust, S Soundara Bala, Randy Van Ommeren, Alessia Portante et autres

ca (code pays fourni par la source)

Intelligent feature engineering and ontological mapping of brain tumour histomorphologies by deep learning

Kevin Faust, S Soundara Bala, Randy Van Ommeren, Alessia Portante et autres

ca (code pays fourni par la source)