Y Ueba

Insulin Dosing Is Associated With Cardiac Sympathetic Predominance Independent of Glycemic Profiles in Type 1 Diabetes Under Free-Living Conditions

Aki Kondo, Kaori Ikeda, Shizuka Kaneko, Shinichi Harashima et autres

While insulin activates the sympathetic nervous system in experimental settings, whether therapeutic insulin administration is associated with cardiac sympathetic predominance under free-living conditions remains unclear. This prospective observational study investigated the association between insulin dosing and cardiac autonomic balance in adults with …

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Oral Semaglutide in an East Asian Population With Overweight or Obesity, With or Without Type 2 Diabetes

Takashi Kadowaki, Line Dam Heftdal, Hae‐Jin Ko, Maria Overvad et autres

Importance: The efficacy and safety of oral semaglutide, 50 mg, in an East Asian population that also includes individuals with type 2 diabetes (T2D), who are prone to weight-related complications at lower body mass index (BMI; calculated as weight in kilograms divided …

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Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study

Y Ueba, Kaori Ikeda, Yasuharu Tabara, Takeo Nakayama et autres

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few reports on dietary patterns associated with MASLD except for the Mediterranean diet. This …

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An exploratory study of factors in disordered eating behavior in diabetes self‐management in Japan

Sachiko Tsukamoto‐Kawashima, Kaori Ikeda, Masakatsu Sone, Masahito Ogura et autres

AIMS/INTRODUCTION: Diet directly affects glucose metabolism, and eating behavior is influenced by various daily life stressors. This study was conducted to investigate the relationship between common psychosomatic stressors on endocrine hormones and eating behavior in patients with type 2 diabetes. MATERIALS AND …

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1224-P: Glucagon Secretion Increases with Age in People with Type 2 Diabetes

Shizuka Kaneko, Kazuya Motohashi, Y Ueba, Shinsuke Tokumoto

It has been shown that the decline in the number of pancreatic beta cells and the insulin-secreting capacity of individual pancreatic beta cells progressively decreases with age, and this functional decline is accelerated by the addition of hyperglycemia. While, glucagon (GCG) is …

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Delayed-onset immune-related adverse events involving the thyroid gland by immune checkpoint inhibitors in combination with chemotherapy: a case report and retrospective cohort study

Y Ueba, Ichiro Yamauchi, Takuro Hakata, Haruka Fujita et autres

Immune checkpoint inhibitors (ICIs) frequently cause immune-related adverse events (irAEs) that often involve endocrine organs. Pembrolizumab and atezolizumab are currently administered in combination with chemotherapy for several malignancies. Although transient thyrotoxicosis within 6 weeks after the first ICI dose is the typical …

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1386-P: Confirmation of the Criteria for Insulin Administration at the Start of Steroid Therapy

Shizuka Kaneko, Kazuya Motohashi, TOMOKO MINAMI, Y Ueba et autres

Blood glucose elevates at initial high-dose steroid (HDS) administration and is prolonged by persistent amplification of glucagon-induced glycogenesis. Insulin (INS) administration at initial dose of HDS will avoid this. However, INS administration criteria regarding BS elevation are not defined. HDS were given …

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Voxel‐based specific regional analysis system for Alzheimer’s disease utility as a screening tool for unrecognized cognitive dysfunction of elderly patients in diabetes outpatient clinics: Multicenter retrospective exploratory study

Y Ueba, Takaaki Murakami, Taizo Yamamoto, Akira Kuroe et autres

AIMS/INTRODUCTION: An efficient screening strategy for identification of cognitive dysfunction remains a clinical issue in the management of elderly adults with diabetes. A magnetic resonance imaging voxel-based specific regional analysis system for Alzheimer's disease (VSRAD) has been developed as an automated brain …

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1090-P: Diabetes in Japanese COVID-19 Patients as the Primary Factor of Accelerated Progression to Severe State

Shizuka Kaneko, Hideo Kita, Kazuya Motohashi, Shinsuke Tokumoto et autres

During the COVID-19 pandemic, Japanese victims number less than in other countries, perhaps due to gene specifics, aspects of Japanese lifestyle and coagulation system characteristics typically less potent in Japanese than in Caucasians. The Osaka prefectural government stratified patients into mild, moderate …

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Identification of Undetected Dementia and Hypoglycemic Risk Using the Dementia Assessment Sheet for Community-Based Integrated Care System 21-Items in the Glycohemoglobin-Guided Management of Elderly Individuals with Diabetes: An Exploratory Study

Takuma Yasuda, Takaaki Murakami, Y Ueba, Haruka Fujita et autres

Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes

Takaaki Murakami, Y Ueba, Yuya Shinoto, Yasutoshi Koga et autres

Mitochondrial diabetes mellitus is a subtype of diabetes linked to mutations in mitochondrial DNA. In patients with mitochondrial diabetes mellitus, the effect of glycemic control on the serum concentrations of fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) has …

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Nerve regeneration over a 20-mm gap through a nerve conduit containing blood vessels in rats: the influence of interstump distance on nerve regeneration.

Ryosuke Kakinoki, N. Nishijima, Y Ueba, Oka M et autres

BACKGROUND: The present study was conducted in rats to investigate whether a tube with additional intrachamber vascularization could permit axons to extend over a distance greater than 10 mm, which appears to be the maximum axon regeneration distance for rat sciatic nerve …

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