Ioanna Théodorou

Acinetobacter baumannii: Setup and characterization of pneumonia and septicemia preclinical models with longitudinal monitoring using bioluminescent strains

Abdessalem Rekiki, Mohit Saxena, Aurore Gaudin, Ioanna Théodorou et autres

International audience

A nanoluciferase-encoded bacteriophage illuminates viral infection dynamics of Pseudomonas aeruginosa cells

Sophia Zborowsky, Quentin Balacheff, Ioanna Théodorou, Rokhaya Kane et autres

Abstract Bacteriophages (phages) are increasingly considered for both treatment and early detection of bacterial pathogens given their specificity and rapid infection kinetics. Here, we exploit an engineered phage expressing nanoluciferase to detect signals associated with Pseudomonas aeruginosa lysis spanning single cells to …

fr, us (code pays fourni par la source)

Targeting hormone refractory prostate cancer by in vivo selected DNA libraries in an orthotopic xenograft mouse model

Laia Civit, Ioanna Théodorou, Franziska S. Frey, Holger Weber et autres

The targeting of specific tissue is a major challenge for the effective use of therapeutics and agents mediating this targeting are strongly demanded. We report here on an in vivo selection technology that enables the de novo identification of pegylated DNA aptamers …

de, fr, nl (code pays fourni par la source)

Tumor targeted micellar nanocarriers assembled from epipodophyllotoxin-based amphiphiles

Julien Alliot, Ioanna Théodorou, Dinh‐Vu Nguyen, Cynthia Forier et autres

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic PEG unit and a hydrophobic stearyl chain. The epipodophyllotoxin-containing amphiphiles were assembled into the corresponding micelles which were evaluated in vivo …

fr (code pays fourni par la source)

Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

Julien Alliot, Ioanna Théodorou, Frederic Ducongè, Edmond Gravel et autres

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic targeting spermine unit, and a hydrophobic stearyl chain. The amphiphilic drug conjugates were further assembled into the corresponding micelles and evaluated …

fr, us (code pays fourni par la source)

Subtle changes in network composition impact the biodistribution and tumor accumulation of nanogels

Ilona Zilkowski, Ioanna Théodorou, Krystyna Albrecht, Frederic Ducongè et autres

We studied the effect of subtle changes in side-chain chemistry and labelling with near infrared fluorophores of nanogels (NGs) prepared from thiolated poly(glycidol) on in vivo biodistribution in mice bearing human breast tumor xenografts. The stability and amphiphilic character of the side …

de, fr, us (code pays fourni par la source)

Évaluation des nanoparticules et des aptamères pour le ciblage des tumeurs in vivo par l'imagerie optique

Ioanna Théodorou

During this PhD project, optical imaging was used to study the biodistribution of different types of nanoparticles for passive tumor targeting and several candidate aptamers selected by in vivo SELEX for active tumor targeting, in animal models of cancer. For the part …

fr (code pays fourni par la source)

Evaluation of nanoparticles and aptamers for in vivo tumor targeting using optical imaging

Ioanna Théodorou

Évaluation des nanoparticules et des aptamères pour le ciblage des tumeurs in vivo par l'imagerie optique Au cours de ce projet de thèse, l'imagerie optique a été utilisé pour étudier la biodistribution de différents types de nanoparticules pour un ciblage passif de …

fr (code pays fourni par la source)

In Vitro and In Vivo Imaging of Fluorescent Aptamers

Ioanna Théodorou, Nam Nguyen Quang, Karine Gombert, Benoît Thezé et autres

fr (code pays fourni par la source)

Stable and compact zwitterionic polydiacetylene micelles with tumor-targeting properties

Ioanna Théodorou, Parambath Anilkumar, Benoît Lelandais, Damien Clarisse et autres

Compact polymerized polydiacetylene-micelles with "stealth" zwitterionic surface coating were assembled and tested in a murine xenograft model of breast cancer. In vivo fluorescence imaging indicated accumulation in the tumor area and histological studies revealed predominant uptake of the micelles at the margins …

fr, us (code pays fourni par la source)

Nanometric Micelles with Photo‐Triggered Cytotoxicity

Parambath Anilkumar, Edmond Gravel, Ioanna Théodorou, Karine Gombert et autres

The development of a photo‐responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo‐labile nitrobenzyl group. The resulting amphiphilic units are self‐assembled in …

fr (code pays fourni par la source)

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)

Joseph M. Dragavon, Carolyn Sinow, Alexandra D. Holland, Abdessalem Rekiki et autres

Fluorescence by Unbound Excitation from Luminescence (FUEL) is a radiative excitation-emission process that produces increased signal and contrast enhancement in vitro and in vivo. FUEL shares many of the same underlying principles as Bioluminescence Resonance Energy Transfer (BRET), yet greatly differs in …

fr, us, au (code pays fourni par la source)