Accès ouvert
2026
preprint
OpenAlex
Hamidullah Khan, Steven V John, Sushmita Roy, Muhammad Farhan et autres
SUMMARY Cancer cell dissemination critically determines clinical prognosis, yet metabolic dependencies and corresponding therapeutic targets during spread of lymphoid malignancies remain poorly understood. Here we show that the pyruvate branch point operates as a metabolic checkpoint for lymphoid cancer cell migration and …
us
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Accès ouvert
2025
conference-abstract
OpenAlex
Christine E. Ryan, Victoria Wang, Mitchell Reed Smith, Brian G. Till et autres
Abstract Background The prognostic utility of positron emission tomography/computer tomography (PET/CT) scan and bone marrow biopsy (BMB) as response assessments in mantle cell lymphoma (MCL) is incompletely explored. We sought to: 1) interrogate the prognostic impact of a mid-induction PET/CT scan, and …
us, Afrique du Sud, ca, my
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Accès ouvert
2025
conference-abstract
OpenAlex
Mark Oliver, Timothy Martin Schmidt, David T. Yang
Abstract Background: As a minimally invasive procedure, abdominal fat pad biopsy is commonly used as an initial diagnostic screening tool in cases of suspected systemic amyloidosis. However, the reported utility of abdominal fat pad biopsies is highly variable in the literature and …
us
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Accès ouvert
2025
conference-abstract
OpenAlex
Jacob Levy, Sophia Kekchidou, Richard Van Krieken, Xun Li et autres
Background Profiling of tumor resistance is critical for advancing precision oncology in breast cancer. Current immunohistochemistry protocols are constrained by the number of markers that can be assessed concurrently, and reliance on multiple rounds of antigen retrieval and sequential staining. These issues …
us
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Accès ouvert
2025
article
OpenAlex
Yasmeen George, Deval Mehta, Longting Lin, Chushuang Chen et autres
ABSTRACT BACKGROUND AND PURPOSE: Predicting the final location and volume of lesions in acute ischemic stroke (AIS) is crucial for clinical management. While CT perfusion (CTP) imaging is routinely used for estimating lesion outcomes, conventional threshold-based methods have limitations. We developed specialized …
au
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Accès ouvert
2025
preprint
OpenAlex
Van Dang, Brittney Voigt, David T. Yang, Gabriel Hoogerbrugge et autres
Protein-protein interactions underlie core brain functions, including neurotransmitter release, receptor activation, and intracellular signaling essential for learning, memory, and cognition. Here, we systematically map conserved brain protein interactions across five vertebrate species-rabbit, chicken, dolphin, pig, and mouse-using co-fractionation and immunoprecipitation mass spectrometry. …
us
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Accès ouvert
2025
article
OpenAlex
Bridget E. Crossman, Regan L. Harmon, Mari Iida, Jillian M. Adams et autres
Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with no targeted treatment modalities. Currently, combination chemotherapy and immune checkpoint inhibitor (ICI) therapy are options for many TNBC patients; however, their efficacy is limited. Understanding what makes TNBCs responsive …
us
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
David T. Yang, Zachary Tom, Mina Tanios
Abstract Introduction Mounier-Kuhn syndrome (MKS), or tracheobronchomegaly, is a rare congenital disorder characterized by marked dilation of the trachea and major bronchi, resulting from atrophy of the elastic and muscular tissues of the airway walls. Though typically diagnosed in younger adults, the …
us
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Accès ouvert
2025
article
OpenAlex
Mariko Isshiki, Ishana Raghuram, Chynna Smith, Hersh V. Gupta et autres
Introduction: MPS VII is an ultra-rare, autosomal recessive, debilitating, progressive lysosomal storage disease caused by beta-glucuronidase (GUSB) enzyme deficiency.Enzyme replacement therapy with vestronidase alfa (VA), a recombinant human GUS, is approved for MPS VII treatment.Methods: The DMP is an ongoing, multicenter, observational …
us, qa
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Accès ouvert
2025
article
OpenAlex
Bradley S. Uyemura, Zhanhai Li, David T. Yang, Michael J. Fallon et autres
Primary central nervous system post-transplant lymphoproliferative disorders (PCNS-PTLD) are rare complications of transplantation. Due to PCNS-PTLD’s scarcity, optimal treatments, risk factors, and outcomes are poorly characterized. By retrospective analysis of 20 patients treated at the University of Wisconsin between the years 2000–2022, …
us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Ethan Wang, L Li, A. Barbara. Chase, Sarah Perman et autres
Introduction: Bystander Cardiopulmonary Resuscitation (CPR) is crucial to the survival of out of hospital cardiac arrest (OHCA) patients, but only 40.2% received bystander CPR in 2023. Asian Americans are less likely to receive bystander CPR in witnessed OHCA versus Non-Hispanic Whites. Existing …
us
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Accès ouvert
2024
conference-abstract
OpenAlex
Nina D. Wagner‐Johnston, Opeyemi A. Jegede, Stephen E. F. Spurgeon, Kami J. Maddocks et autres
Introduction: The optimal induction for younger fit patients (pts) with mantle cell lymphoma (MCL) is unknown; though intensive chemoimmunotherapy (CIT) containing high dose cytarabine has been shown to prolong remission. Achieving molecular remission is an independent predictor of outcomes post induction therapy …
us
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