Jillian M. Adams

Tumor-associated MerTK promotes a pro-inflammatory microenvironment and enhances immune checkpoint inhibitor response in triple-negative breast cancer

Bridget E. Crossman, Regan L. Harmon, Mari Iida, Jillian M. Adams et autres

Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with no targeted treatment modalities. Currently, combination chemotherapy and immune checkpoint inhibitor (ICI) therapy are options for many TNBC patients; however, their efficacy is limited. Understanding what makes TNBCs responsive …

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From Bench to Bedside: A Team’s Approach to Multidisciplinary Strategies to Combat Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma

Bridget E. Crossman, Regan L. Harmon, Kourtney L. Kostecki, Nellie K. McDaniel et autres

Head and neck squamous cell carcinoma (HNSCC) is diagnosed in more than 71,000 patients each year in the United States, with nearly 16,000 associated deaths. One significant hurdle in the treatment of HNSCC is acquired and intrinsic resistance to existing therapeutic agents. …

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MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer

Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki, Christine E. Glitchev et autres

Triple-negative breast cancer (TNBC) is characterized by the absence of the estrogen receptor, progesterone receptor, and receptor tyrosine kinase HER2 expression. Due to the limited number of FDA-approved targeted therapies for TNBC, there is an ongoing need to understand the molecular underpinnings …

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Abstract 6994: MerTK drives proliferation and metastasis activity in triple negative breast cancer

Christine E. Glitchev, Mari Iida, Bridget E. Crossman, Kourtney L. Kostecki et autres

Abstract Triple negative breast cancer (TNBC) is characterized by the absence of estrogen, progesterone, and HER2 receptors. It exhibits a higher level of aggressiveness compared to other types of breast cancer, with a greater likelihood of recurrence following standard treatments such as …

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Application of an extended inverse method for the determination of ice-induced loads on ships

Jillian M. Adams

With the opening of more Arctic shipping routes, the motivation to design safe and efficient ice-going ships has increased. Recently, knowledge of ship-ice interactions and the mechanics of icebreaking processes has improved through numerous full-scale studies; however, the understanding of precise ice-induced …