Haruki Jimbo

Anti‐ BP180 Mucosal Membrane Pemphigoid With a History of Maxillary Carcinoma With Antibodies to 190 kDa Periplakin and 210 kDa Envoplakin: A Case Report

Mami Kishimoto, Marie Ohata, Haruki Jimbo, Takashi Hashimoto et autres

Mucous membrane pemphigoid (MMP) primarily affects the mucosal surfaces with minimal skin involvement. Approximately 70% of MMP cases show positivity for anti-BP180 antibodies. Paraneoplastic pemphigus (PNP) typically presents with antibodies against periplakin and envoplakin. We report a case of anti-BP180 MMP with …

jp (code pays fourni par la source)

A multi-center, cross-sectional questionnaire survey in Japan (KOBE study) exploring factors associated with primary focal hyperhidrosis

T. Fukumoto, Marie Ohata, Y Matsumoto, Masashi Ashida et autres

Background/aim: Primary focal hyperhidrosis (PFH) is defined as a condition characterized by excessive sweating in localized areas, which causes patients to experience difficulties in daily life, regardless of temperature or psychological stress. Previous surveys in Japan have revealed that the majority of …

jp, fr, ca, us (code pays fourni par la source)

Chemo-Senolytic Therapeutic Potential against Angiosarcoma

Xuebing Wang, Claire Chung, Ai Yoshioka, Shinya Hashimoto et autres

Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, a taxane (genotoxic drug), although it has a limited effect owing to chemoresistance to prolonged treatment. In this study, we examine an alternative angiosarcoma treatment …

jp, us (code pays fourni par la source)

Treatment of dermal ulcer with autologous fibrin glue: Two case reports of an exploratory prospective pilot study

Shinichiro Kawamoto, Eriko Shinkawa, Susumu Fujiwara, Yoshiko Oda et autres

INTRODUCTION: The healing of recurrent and refractory skin ulcers requires a long time, during which there is risk of infection, and hospital admission is occasionally required for surgical or daily conservative treatment. Therefore, the development of promising treatments that promote faster, uneventful …

jp (code pays fourni par la source)

Chemo-senolytic therapeutic potential against angiosarcoma

Xuebing Wang, Claire Chung, Ai Yoshioka, Shinya Hashimoto et autres

Abstract Angiosarcoma is an aggressive soft-tissue sarcoma with a poor prognosis. Chemotherapy for this cancer typically employs paclitaxel, one of the taxanes (genotoxic drugs), although it has a limited effect due to chemoresistance for prolonged treatment. Here we examine a new angiosarcoma …

jp, us (code pays fourni par la source)

Severe and delayed-onset acneiform eruptions as an adverse reaction to regorafenib

Haruhiko Otsuka, Takeshi Fukumoto, Naomi Kiyota, Chihiro Takemori et autres

Regorafenib is an oral multikinase inhibitor targeting several tyrosine kinase receptors including BRAF and epidermal growth factor receptor (EGFR) and is approved as a third-line treatment for metastatic gastrointestinal stromal tumor (GIST). While acneiform eruptions have been observed in patients receiving other …

jp (code pays fourni par la source)

NUMB as a Therapeutic Target for Melanoma

Denitsa M. Hristova, Takeshi Fukumoto, Chihiro Takemori, Le Gao et autres

The upregulation of the adaptor protein NUMB triggers melanocytic differentiation from multipotent skin stem cells, which share many properties with aggressive melanoma cells. Although NUMB acts as a tumor suppressor in various human cancer types, little is known about its role in …

us, jp (code pays fourni par la source)

Severe and delayed-onset acneiform eruptions as an adverse reaction to regorafenib

Haruhiko Otsuka, Takeshi Fukumoto, Naomi Kiyota, Chihiro Takemori et autres

Regorafenib is an oral multikinase inhibitor targeting several tyrosine kinase receptors including BRAF and epidermal growth factor receptor (EGFR), and is approved as a third-line treatment for metastatic gastrointestinal stromal tumor (GIST). While acneiform eruptions have been observed in patients receiving other …

jp (code pays fourni par la source)

Koebner phenomenon seen in a case of drug‐induced granular C3 dermatosis

Marie Ohata, Takeshi Fukumoto, Takashi Hashimoto, Chihiro Takemori et autres

We would like to

jp (code pays fourni par la source)

295 The role of NUMB in melanoma

Takeshi Fukumoto, Denitsa M. Hristova, Haruki Jimbo, Chihiro Takemori et autres

jp, us (code pays fourni par la source)

Dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid showing positive autoantibody responses to multiple epitopes

Rikuma Kitao, Takeshi Fukumoto, Takashi Hashimoto, Kentaro Izumi et autres

jp (code pays fourni par la source)

Intravenous immunoglobulin‐induced severe vesicular eczematous eruption successfully treated with narrow band‐ultraviolet B therapy

Rina Koizumi, Takeshi Fukumoto, Haruki Jimbo, Chikako Nishigori

Abstract Intravenous immunoglobulins (IVIg) are increasingly being used to treat a wide spectrum of dermatological and neurological autoimmune diseases. Although the administration of IVIg does not usually result in severe adverse reactions, side effects of IVIg reportedly occur in 6‐13% of patients. …

jp (code pays fourni par la source)